Zobrazeno 1 - 10
of 132
pro vyhledávání: '"Alain, de Bruin"'
Autor:
Martijn G. S. Rutten, Yu Lei, Joanne H. Hoogerland, Vincent W. Bloks, Hong Yang, Trijnie Bos, Kishore A. Krishnamurthy, Aycha Bleeker, Mirjam H. Koster, Rachel E. Thomas, Justina C. Wolters, Hilda van den Bos, Gilles Mithieux, Fabienne Rajas, Adil Mardinoglu, Diana C. J. Spierings, Alain de Bruin, Bart van de Sluis, Maaike H. Oosterveer
Publikováno v:
Cancer & Metabolism, Vol 11, Iss 1, Pp 1-11 (2023)
Abstract Background Glycogen storage disease type 1a (GSD Ia) is an inborn error of metabolism caused by a defect in glucose-6-phosphatase (G6PC1) activity, which induces severe hepatomegaly and increases the risk for liver cancer. Hepatic GSD Ia is
Externí odkaz:
https://doaj.org/article/176971327ab64839a0921d89e984a866
Autor:
Catriona Ling, Christian J. Versloot, Matilda E. Arvidsson Kvissberg, Guanlan Hu, Nathan Swain, José M. Horcas-Nieto, Emily Miraglia, Mehakpreet K. Thind, Amber Farooqui, Albert Gerding, Karen van Eunen, Mirjam H. Koster, Niels J. Kloosterhuis, Lijun Chi, YueYing ChenMi, Miriam Langelaar-Makkinje, Celine Bourdon, Jonathan Swann, Marieke Smit, Alain de Bruin, Sameh A. Youssef, Marjon Feenstra, Theo H. van Dijk, Kathrin Thedieck, Johan W. Jonker, Peter K. Kim, Barbara M. Bakker, Robert H.J. Bandsma
Publikováno v:
EBioMedicine, Vol 96, Iss , Pp 104809- (2023)
Summary: Background: The intestine of children with severe malnutrition (SM) shows structural and functional changes that are linked to increased infection and mortality. SM dysregulates the tryptophan-kynurenine pathway, which may impact processes s
Externí odkaz:
https://doaj.org/article/030dcd61c99342418554af2a1f59e28d
Autor:
Venetia Bazioti, Anouk M. La Rose, Sjors Maassen, Frans Bianchi, Rinse de Boer, Benedek Halmos, Deepti Dabral, Emma Guilbaud, Arthur Flohr-Svendsen, Anouk G. Groenen, Alejandro Marmolejo-Garza, Mirjam H. Koster, Niels J. Kloosterhuis, Rick Havinga, Alle T. Pranger, Miriam Langelaar-Makkinje, Alain de Bruin, Bart van de Sluis, Alison B. Kohan, Laurent Yvan-Charvet, Geert van den Bogaart, Marit Westerterp
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-23 (2022)
Cholesterol efflux is mediated by specific transporters in T cells. Here the authors show that when the ABCA1/ABCG1 cholesterol transporters are absent, peripheral T cell numbers are reduced but activation increased with a premature aging phenotype o
Externí odkaz:
https://doaj.org/article/cce4b1448a8b440488b90cdc27f0a71a
Autor:
Rodanthi Lyraki, Anaëlle Grabek, Amélie Tison, Lahiru Chamara Weerasinghe Arachchige, Mirko Peitzsch, Nicole Bechmann, Sameh A. Youssef, Alain de Bruin, Elvira R. M. Bakker, Frank Claessens, Marie-Christine Chaboissier, Andreas Schedl
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 6 (2023)
Externí odkaz:
https://doaj.org/article/3cf6a8997a32457ab1865951264cbcb2
Autor:
Klaske M. Schukken, Yinan Zhu, Petra L. Bakker, Mirjam H. Koster, Liesbeth Harkema, Sameh A. Youssef, Alain de Bruin, Floris Foijer
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract Chromosomal instability (CIN) is a hallmark of cancer, leading to aneuploid cells. To study the role that CIN plays in tumor evolution, several mouse models have been engineered over the last 2 decades. These models have unequivocally shown
Externí odkaz:
https://doaj.org/article/2ee0cafcaa344471b97c2a117ffcebdc
Autor:
Andries Heida, Nanda Gruben, Leen Catrysse, Martijn Koehorst, Mirjam Koster, Niels J. Kloosterhuis, Albert Gerding, Rick Havinga, Vincent W. Bloks, Laura Bongiovanni, Justina C. Wolters, Theo van Dijk, Geert van Loo, Alain de Bruin, Folkert Kuipers, Debby P.Y. Koonen, Bart van de Sluis
Publikováno v:
Molecular Metabolism, Vol 54, Iss , Pp 101349- (2021)
Objective: Obesity-related chronic inflammation plays an important role in the development of Metabolic Associated Fatty Liver Disease (MAFLD). Although the contribution of the pro-inflammatory NF-κB signaling pathway to the progression from simple
Externí odkaz:
https://doaj.org/article/54c1ebb08d38492b9a76c2c3c92de6e6
Autor:
Bhagyashree S. Joshi, Sameh A. Youssef, Reinier Bron, Alain de Bruin, Harm H. Kampinga, Inge S. Zuhorn
Publikováno v:
iScience, Vol 24, Iss 11, Pp 103282- (2021)
Summary: Huntington disease (HD) is a devastating neurodegenerative disorder characterized by aggregation of huntingtin (HTT) protein containing expanded polyglutamine (polyQ) tracts. DNAJB6, a member of the DNAJ chaperone family, was reported to eff
Externí odkaz:
https://doaj.org/article/7e72da794b2c4764b06ad74b280ea482
Autor:
Noortje Ijssennagger, Kristel S. van Rooijen, Stefanía Magnúsdóttir, José M. Ramos Pittol, Ellen C.L. Willemsen, Marcel R. de Zoete, Matthijs J.D. Baars, Paul B. Stege, Carolina Colliva, Roberto Pellicciari, Sameh A. Youssef, Alain de Bruin, Yvonne Vercoulen, Folkert Kuipers, Saskia W.C. van Mil
Publikováno v:
JHEP Reports, Vol 3, Iss 5, Pp 100344- (2021)
Background & Aims: The interorgan crosstalk between the liver and the intestine has been the focus of intense research. Key in this crosstalk are bile acids, which are secreted from the liver into the intestine, interact with the microbiome, and upon
Externí odkaz:
https://doaj.org/article/d6f47344bb9a4166b5afc39b37bff9cd
Autor:
Inez Johanna, Patricia Hernández-López, Sabine Heijhuurs, Wouter Scheper, Laura Bongiovanni, Alain de Bruin, Dennis X. Beringer, Rimke Oostvogels, Trudy Straetemans, Zsolt Sebestyen, Jürgen Kuball
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
γδT cell receptors (γδTCRs) recognize a broad range of malignantly transformed cells in mainly a major histocompatibility complex (MHC)-independent manner, making them valuable additions to the engineered immune effector cell therapy that current
Externí odkaz:
https://doaj.org/article/e17f0e99771741b296928ed52e569024
Autor:
Laura Bongiovanni, Anneloes Andriessen, Serenella Silvestri, Ilaria Porcellato, Chiara Brachelente, Alain de Bruin
Publikováno v:
Frontiers in Veterinary Science, Vol 8 (2021)
Uncontrolled proliferation is a key feature of tumor progression and malignancy. This suggests that cell-cycle related factors could be exploited as cancer biomarkers and that pathways specifically involved in the cell cycle, such as the Rb-E2F pathw
Externí odkaz:
https://doaj.org/article/4fbbe905014c46b5950f04280c6f3d3c