Zobrazeno 1 - 10
of 262
pro vyhledávání: '"Alain, Prochiantz"'
Autor:
Ariel A. Di Nardo, Alain Prochiantz
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
Cell signaling based on homeoprotein transfer is a pathway with developmental and physiological functions. For a few transcription factors of this family, primarily ENGRAILED1, ENGRAILED2 and OTX2, their physiological functions have led to therapeuti
Externí odkaz:
https://doaj.org/article/f1bf5ddb1fe145c2bbd135a0be3e97a0
Publikováno v:
Neural Regeneration Research, Vol 17, Iss 3, Pp 690-696 (2022)
Retinal ganglion cell (RGC) axons provide the only link between the light sensitive and photon transducing neural retina and visual centers of the brain. RGC axon degeneration occurs in a number of blinding diseases and the ability to stimulate axon
Externí odkaz:
https://doaj.org/article/d59fb0a2797f4d95b7aed3b263ee7e4e
Autor:
Alain Joliot, Alain Prochiantz
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Unconventional secretion allows for the secretion of fully mature and biologically active proteins mostly present in the cytoplasm or nucleus. Besides extra vesicle-driven secretion, non-extravesicular pathways also exist that specifically rely on th
Externí odkaz:
https://doaj.org/article/3ccbca0806204a84b0b0964313b8d02f
Autor:
Camille Ravel-Godreuil, Olivia Massiani-Beaudoin, Philippe Mailly, Alain Prochiantz, Rajiv L. Joshi, Julia Fuchs
Publikováno v:
iScience, Vol 24, Iss 7, Pp 102756- (2021)
Summary: Age is a major risk factor for neurodegenerative diseases like Parkinson’s disease, but few studies have explored the contribution of key hallmarks of aging, namely DNA methylation changes and heterochromatin destructuration, in the neurod
Externí odkaz:
https://doaj.org/article/68a9de6da70348f1b6386111b62eb912
Autor:
Anabelle Planques, Vanessa Oliveira Moreira, David Benacom, Clémence Bernard, Laurent Jourdren, Corinne Blugeon, Florent Dingli, Vanessa Masson, Damarys Loew, Alain Prochiantz, Ariel A. Di Nardo
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 16, p 8951 (2021)
The choroid plexus is an important blood barrier that secretes cerebrospinal fluid, which essential for embryonic brain development and adult brain homeostasis. The OTX2 homeoprotein is a transcription factor that is critical for choroid plexus devel
Externí odkaz:
https://doaj.org/article/fda816d392d54079b059c6fbf3232f23
Autor:
Hocine Rekaik, François-Xavier Blaudin de Thé, Julia Fuchs, Olivia Massiani-Beaudoin, Alain Prochiantz, Rajiv L. Joshi
Publikováno v:
Cell Reports, Vol 13, Iss 2, Pp 242-250 (2015)
Engrailed homeoproteins are expressed in adult dopaminergic neurons of the substantia nigra. In Engrailed1 heterozygous mice, these neurons start dying at 6 weeks, are more sensitive to oxidative stress, and progressively develop traits similar to th
Externí odkaz:
https://doaj.org/article/b2324fb06af645a095c7fd0562e7ee82
Autor:
Ulrika Nordström, Geneviève Beauvais, Anamitra Ghosh, Baby Chakrapani Pulikkaparambil Sasidharan, Martin Lundblad, Julia Fuchs, Rajiv L. Joshi, Jack W. Lipton, Andrew Roholt, Satish Medicetty, Timothy N. Feinstein, Jennifer A. Steiner, Martha L. Escobar Galvis, Alain Prochiantz, Patrik Brundin
Publikováno v:
Neurobiology of Disease, Vol 73, Iss , Pp 70-82 (2015)
Current research on Parkinson's disease (PD) pathogenesis requires relevant animal models that mimic the gradual and progressive development of neuronal dysfunction and degeneration that characterizes the disease. Polymorphisms in engrailed 1 (En1),
Externí odkaz:
https://doaj.org/article/5ecbd7f88ea046b8b6a6dce32b3f3ab4
Autor:
Mélanie Leboeuf, Stephanie E. Vargas-Abonce, Eugénie Pezé-Hedsieck, Edmond Dupont, Lucia Jimenez-Alonso, Kenneth L. MOYA, Alain Prochiantz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7febd977c67882f0a875b8ac76eed6b0
https://doi.org/10.15252/rc.2022317911
https://doi.org/10.15252/rc.2022317911
ENGRAILED-1 transcription factor has a paracrine neurotrophic activity on adult spinal α-motoneurons
Autor:
Mélanie Lebœuf, Stephanie E. Vargas-Abonce, Eugénie Pezé-Hedsieck, Edmond Dupont, Lucia Jimenez-Alonso, Kenneth L. Moya, Alain Prochiantz
Several homeoprotein transcription factors transfer between cells and regulate gene expression, protein translation, and chromatin organization in recipient cells. ENGRAILED-1 is one such homeoprotein expressed in spinal V1 interneurons synapsing on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b46529d97645cb5d5cda8dba94a942a4
https://doi.org/10.1101/2022.08.16.504081
https://doi.org/10.1101/2022.08.16.504081
Autor:
Julien Spatazza, Henry H.C. Lee, Ariel A. Di Nardo, Lorenzo Tibaldi, Alain Joliot, Takao K. Hensch, Alain Prochiantz
Publikováno v:
Cell Reports, Vol 3, Iss 6, Pp 1815-1823 (2013)
Brain plasticity is often restricted to critical periods in early life. Here, we show that a key regulator of this process in the visual cortex, Otx2 homeoprotein, is synthesized and secreted globally from the choroid plexus. Consequently, Otx2 is ma
Externí odkaz:
https://doaj.org/article/23e7f4b5cf804284bd12e0fc37de65d8