Zobrazeno 1 - 10
of 125
pro vyhledávání: '"Alain, Laederach"'
Autor:
Rebeccah K. Stewart, Patrick Nguyen, Alain Laederach, Pelin C. Volkan, Jessica K. Sawyer, Donald T. Fox
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Regulation of codon optimality is an increasingly appreciated layer of cell- and tissue-specific protein expression control. Here, we use codon-modified reporters to show that differentiation of Drosophila neural stem cells into neurons enab
Externí odkaz:
https://doaj.org/article/ebf9891368994effa71105e61f20d572
Autor:
Jayashree Kumar, Lela Lackey, Justin M Waldern, Abhishek Dey, Anthony M Mustoe, Kevin M Weeks, David H Mathews, Alain Laederach
Publikováno v:
eLife, Vol 11 (2022)
Splicing is highly regulated and is modulated by numerous factors. Quantitative predictions for how a mutation will affect precursor mRNA (pre-mRNA) structure and downstream function are particularly challenging. Here, we use a novel chemical probing
Externí odkaz:
https://doaj.org/article/7e9b5b2f330645718e814d97ac9b25a0
Autor:
Scott R Allen, Rebeccah K Stewart, Michael Rogers, Ivan Jimenez Ruiz, Erez Cohen, Alain Laederach, Christopher M Counter, Jessica K Sawyer, Donald T Fox
Publikováno v:
eLife, Vol 11 (2022)
Codon usage bias has long been appreciated to influence protein production. Yet, relatively few studies have analyzed the impacts of codon usage on tissue-specific mRNA and protein expression. Here, we use codon-modified reporters to perform an organ
Externí odkaz:
https://doaj.org/article/6c13272b3ef34ec284eeebefc16be53b
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 12, p e1009632 (2021)
SHAPE-JuMP is a concise strategy for identifying close-in-space interactions in RNA molecules. Nucleotides in close three-dimensional proximity are crosslinked with a bi-reactive reagent that covalently links the 2'-hydroxyl groups of the ribose moie
Externí odkaz:
https://doaj.org/article/c8a006f61d6a475692a933302ef37614
Autor:
Lela Lackey, Aaztli Coria, Auyon J Ghosh, Phil Grayeski, Abigail Hatfield, Vijay Shankar, John Platig, Zhonghui Xu, Silvia B V Ramos, Edwin K Silverman, Victor E Ortega, Michael H Cho, Craig P Hersh, Brian D Hobbs, Peter Castaldi, Alain Laederach
Publikováno v:
PLoS Genetics, Vol 17, Iss 11, p e1009912 (2021)
α1-anti-trypsin (A1AT), encoded by SERPINA1, is a neutrophil elastase inhibitor that controls the inflammatory response in the lung. Severe A1AT deficiency increases risk for Chronic Obstructive Pulmonary Disease (COPD), however, the role of A1AT in
Externí odkaz:
https://doaj.org/article/a9364620e0274197ae0b0ec2bcff504b
Publikováno v:
RNA. 29:691-704
Although not canonically polyadenylated, the long noncoding RNA MALAT1 (metastasis-associated lung adenocarcinoma transcript 1) is stabilized by a highly conserved 76-nt triple helix structure on its 3′ end. The entire MALAT1 transcript is over 800
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23cc442d99bc4d1268e5007bde9d1fbc
https://doi.org/10.1261/rna.079388.122
https://doi.org/10.1261/rna.079388.122
Autor:
Philip J Grayeski, Chase A Weidmann, Jayashree Kumar, Lela Lackey, Anthony M Mustoe, Steven Busan, Alain Laederach, Kevin M Weeks
Publikováno v:
Nucleic Acids Research. 50:9689-9704
SERPINA1 mRNAs encode the protease inhibitor α-1-antitrypsin and are regulated through post-transcriptional mechanisms. α-1-antitrypsin deficiency leads to chronic obstructive pulmonary disease (COPD) and liver cirrhosis, and specific variants in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fb810ff2966ba613603ad6a2c8b20be
https://doi.org/10.1093/nar/gkac739
https://doi.org/10.1093/nar/gkac739
Publikováno v:
bioRxiv
article-version (status) pre
article-version (number) 1
Biophysical Journal
Journal of the American Chemical Society
article-version (status) pre
article-version (number) 1
Biophysical Journal
Journal of the American Chemical Society
With the rapid rate of COVID-19 infections and deaths, treatments and cures besides hand washing, social distancing, masks, isolation, and quarantines are urgently needed. The treatments and vaccines rely on the basic biophysics of the complex viral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca93aaf4ac967e0fb519ec03437006bf
https://doi.org/10.1021/jacs.1c03003
https://doi.org/10.1021/jacs.1c03003
Autor:
Greggory M. Rice, Kevin M. Weeks, Gillian Houlihan, Matthew J. Smola, Catherine A. Giannetti, Philipp Holliger, Thomas W. Christy, Alain Laederach, Jing Wang, Nikolay V. Dokholyan
Publikováno v:
Biochemistry
Higher-order structure governs function for many RNAs. However, discerning this structure for large RNA molecules in solution is an unresolved challenge. Here, we present SHAPE-JuMP (selective 2'-hydroxyl acylation analyzed by primer extension and ju
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3886067b0ebfbff2e4e6ee9d8446f682
https://doi.org/10.1021/acs.biochem.1c00270
https://doi.org/10.1021/acs.biochem.1c00270
Autor:
Aaztli Coria, Anastacia Wienecke, Michael L Knight, Daniel Desirò, Alain Laederach, Alexander Borodavka
Publikováno v:
Nucleic acids research. 50(17)
Funder: National Institute of General Medical Sciences
Funder: NIGMS NIH HHS
Due to genome segmentation, rotaviruses must co-package eleven distinct genomic RNAs. The packaging is mediated by virus-encoded RNA chaperones, such as the rotavi
Funder: NIGMS NIH HHS
Due to genome segmentation, rotaviruses must co-package eleven distinct genomic RNAs. The packaging is mediated by virus-encoded RNA chaperones, such as the rotavi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ed8f308bb8084b86d5e663879c0dd31
https://pubmed.ncbi.nlm.nih.gov/36062555
https://pubmed.ncbi.nlm.nih.gov/36062555