DNA methylation at the suppressor of cytokine signaling 3 (SOCS3) gene influences height in childhood

Autor: Prachand Issarapu, Manisha Arumalla, Hannah R. Elliott, Suraj S. Nongmaithem, Alagu Sankareswaran, Modupeh Betts, Sara Sajjadi, Noah J. Kessler, Swati Bayyana, Sohail R. Mansuri, Maria Derakhshan, G. V. Krishnaveni, Smeeta Shrestha, Kalyanaraman Kumaran, Chiara Di Gravio, Sirazul A. Sahariah, Eleanor Sanderson, Caroline L. Relton, Kate A. Ward, Sophie E. Moore, Andrew M. Prentice, Karen A. Lillycrop, Caroline H. D. Fall, Matt J. Silver, Giriraj R. Chandak, the EMPHASIS study group

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)

Abstract Human height is strongly influenced by genetics but the contribution of modifiable epigenetic factors is under-explored, particularly in low and middle-income countries (LMIC). We investigate links between blood DNA methylation and child hei

Externí odkaz: https://doaj.org/article/ea9bc0f20bff47a5b3eb1876f8c6f819

SWI/SNF Infobase-An exclusive information portal for SWI/SNF remodeling complex subunits.

Autor: Udayakumar Mani, Alagu Sankareswaran S, Arun Goutham R N, Suma Mohan S

Publikováno v: PLoS ONE, Vol 12, Iss 9, p e0184445 (2017)

Chromatin remodeling complexes facilitate the access of condensed genomic DNA during transcription, replication, and repair, by altering the histone-DNA contacts in the nucleosome structures. SWI/SNF (SWItch/Sucrose Non-Fermentable) family of ATP dep

Externí odkaz: https://doaj.org/article/66b5c8f5a0cc44058a511427ecdbc9e5

Babies of South Asian and European Ancestry Show Similar Associations with Genetic Risk Score for Birth Weight Despite the Smaller Size of South Asian Newborns

Autor: Suraj S. Nongmaithem, Robin N. Beaumont, Akshay Dedaniya, Andrew R. Wood, Babatunji-William Ogunkolade, Zahid Hassan, Ghattu V. Krishnaveni, Kalyanaraman Kumaran, Ramesh D. Potdar, Sirazul A. Sahariah, Murali Krishna, Chiara Di Gravio, Inder D. Mali, Alagu Sankareswaran, Akhtar Hussain, Biswajit W. Bhowmik, Abdul Kalam A. Khan, Bridget A. Knight, Timothy M. Frayling, Sarah Finer, Caroline H.D. Fall, Chittaranjan S. Yajnik, Rachel M. Freathy, Graham A. Hitman, Giriraj R. Chandak

Publikováno v: Diabetes

Size at birth is known to be influenced by various fetal and maternal factors including genetic effects. South Asians have a high burden of low birthweight and cardiometabolic diseases, yet studies of common genetic variations underpinning these phen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::383ebd57eabe765fd7d0ec59020d47b5
https://doi.org/10.2337/figshare.18624365

Associations of genetic scores for birth weight with newborn size and later Anthropometric traits and cardiometabolic risk markers in South Asians

Autor: Suraj S Nongmaithem, Robin N Beaumont, Akshay Dedaniya, Andrew R Wood, Babatunji-William Ogunkolade, Zahid Hassan, Ghattu V Krishnaveni, Kalyanaraman Kumaran, Ramesh D Potdar, Sirajul A Sahariah, Murali Krishna, Chiara Di Gravio, Inder D Mali, Alagu Sankareswaran, Akhtar Hussain, Biswajit W Bhowmik, Abdul Kalam A Khan, Bridget A Knight, Timothy M Frayling, Sarah Finer, Caroline HD Fall, Chittaranjan S Yajnik, Rachel M Freathy, Graham A Hitman, Giriraj R Chandak

We recently reported genetic variants associated with birth weight and their effect on future cardiometabolic risk in Europeans. Despite a higher burden of low birth weight and cardiometabolic disorders, such studies are lacking in South Asians. We g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::14e411425859b1ae0b40b4eee0cc912b
https://doi.org/10.1101/2021.04.16.21254284

DNA methylation signatures associated with cardiometabolic risk factors in children from India and The Gambia: results from the EMPHASIS study.

Autor: Antoun, Elie¹ (AUTHOR), Issarapu, Prachand² (AUTHOR), di Gravio, Chiara³ (AUTHOR), Shrestha, Smeeta^2,4 (AUTHOR), Betts, Modupeh⁵ (AUTHOR), Saffari, Ayden⁶ (AUTHOR), Sahariah, Sirazul A.⁷ (AUTHOR), Sankareswaran, Alagu² (AUTHOR), Arumalla, Manisha² (AUTHOR), Prentice, Andrew M.⁵ (AUTHOR), Fall, Caroline H. D.³ (AUTHOR), Silver, Matt J.⁶ (AUTHOR), Chandak, Giriraj R.² (AUTHOR), Lillycrop, Karen A.^1,8 (AUTHOR) kal@soton.ac.uk, the EMPHASIS study group (AUTHOR), Kehoe, Sarah (AUTHOR), Kumaran, Kalyanaraman (AUTHOR), Potdar, Ramesh D. (AUTHOR), Sajjadi, Sara (AUTHOR), Nongmaithem, Suraj (AUTHOR)

Publikováno v: Clinical Epigenetics. 1/9/2022, Vol. 14 Issue 1, p1-16. 16p.