Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Alaeddine Djillani"'
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
TREK-1 is the most studied background K2P channel. Its main role is to control cell excitability and maintain the membrane potential below the threshold of depolarization. TREK-1 is multi-regulated by a variety of physical and chemical stimuli which
Externí odkaz:
https://doaj.org/article/8f58c11c8f8b43acae9e578307e3026b
Autor:
Alaeddine Djillani, Mariel Pietri, Sébastien Moreno, Catherine Heurteaux, Jean Mazella, Marc Borsotto
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2017)
Depression is a devastating mental disorder that affects 20% of the population worldwide. Despite their proven efficacy, antidepressants present a delayed onset of action and serious adverse effects. Seven years ago, we described spadin (PE 12-28) as
Externí odkaz:
https://doaj.org/article/82afa037b625468fb2e7f56da6976764
Autor:
Céline Hivelin, Sophie Béraud-Dufour, Christelle Devader, Amar Abderrahmani, Sébastien Moreno, Hamid Moha ou Maati, Alaeddine Djillani, Catherine Heurteaux, Marc Borsotto, Jean Mazella, Thierry Coppola
Publikováno v:
Journal of Diabetes Research, Vol 2016 (2016)
Inhibition of the potassium channels TREK-1 by spadin (SPA) is currently thought to be a promising therapeutic target for the treatment of depression. Since these channels are expressed in pancreatic β-cells, we investigated their role in the contro
Externí odkaz:
https://doaj.org/article/5ce0b490bc014551ba4a958c50acb044
Publikováno v:
eNeuro. 9(3)
Voltage-gated calcium channel Ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6cefa6bb765440e71dec8b7de7ee1904
https://pubmed.ncbi.nlm.nih.gov/35477860
https://pubmed.ncbi.nlm.nih.gov/35477860
Publikováno v:
Neuropharmacology
Neuropharmacology, Elsevier, 2019, 158, pp.107715. ⟨10.1016/j.neuropharm.2019.107715⟩
Neuropharmacology, Elsevier, 2019, 158, pp.107715. ⟨10.1016/j.neuropharm.2019.107715⟩
Post-stroke depression (PSD) is the most common mood disorder following stroke with high relevance for outcome and survival of patients. The TREK-1 channel represents a crucial target in the pathogenesis of stroke and depression. Spadin and its short
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4ecce096f9431e24b76fded446f89dd
https://pubmed.ncbi.nlm.nih.gov/31325429
https://pubmed.ncbi.nlm.nih.gov/31325429
Publikováno v:
Frontiers in Pharmacology
Frontiers in Pharmacology, Vol 10 (2019)
Frontiers in Pharmacology, Frontiers, 2019, 10, ⟨10.3389/fphar.2019.00379⟩
Frontiers in Pharmacology, 2019, 10, ⟨10.3389/fphar.2019.00379⟩
Frontiers in Pharmacology, Vol 10 (2019)
Frontiers in Pharmacology, Frontiers, 2019, 10, ⟨10.3389/fphar.2019.00379⟩
Frontiers in Pharmacology, 2019, 10, ⟨10.3389/fphar.2019.00379⟩
TREK-1 is the most studied background K2P channel. Its main role is to control cell excitability and maintain the membrane potential below the threshold of depolarization. TREK-1 is multi-regulated by a variety of physical and chemical stimuli which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ffde1bf1b33f4fdaa53ce0a1a89aebf
https://doi.org/10.3389/fphar.2019.00379
https://doi.org/10.3389/fphar.2019.00379
Publikováno v:
Pharmacologytherapeutics. 194
Depression is a devastating mood disorder and a leading cause of disability worldwide. Depression affects approximately one in five individuals in the world and represents heavy economic and social burdens. The neurobiological mechanisms of depressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cd62b84cb84063bd14198333a639986f
https://pubmed.ncbi.nlm.nih.gov/30291907
https://pubmed.ncbi.nlm.nih.gov/30291907
Autor:
Oliver Nüße, Alaeddine Djillani, Tomas Luyten, Jan B. Parys, Isabelle Doignon, Sophie C. Gangloff, Bouchaib Lamkhioued, Olivier Dellis, Christine Chomienne
Publikováno v:
Cell Calcium. 58:171-185
Store-operated Ca(2+) entry (SOCE) is the main Ca(2+) entry pathway of non-excitable cells. In the past decade, the activation of this entry has been unveiled, with STIM1, a protein of the endoplasmic reticulum able to sense the intraluminal Ca(2+) c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6faf025b0906aafae6f41689f0a0cb4b
https://doi.org/10.1016/j.ceca.2015.04.005
https://doi.org/10.1016/j.ceca.2015.04.005
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1843:2341-2347
2-Aminoethyl diphenylborinate (2-APB) is a well-known effector of the store-operated Ca2+ entry of several cell types such as immune cells, platelets and smooth muscle cells. 2-APB has a dual effect: potentiation at 1–5μM and inhibition at >30μM.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e4bb5e6b910e0d8d7a14177372067a6
https://doi.org/10.1016/j.bbamcr.2014.03.012
https://doi.org/10.1016/j.bbamcr.2014.03.012
Publikováno v:
European Psychiatry. 33:S407-S407
ObjectivesWe previously discovered spadin as a new antidepressant drug concept. Spadin exerts its antidepressant actions on the TREK-1 potassium channel, a new antidepressant (AD) target. We have shown that spadin acts more rapidly in comparison to o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05d261f1dab359d077b7d9c75286e32e
https://doi.org/10.1016/j.eurpsy.2016.01.1470
https://doi.org/10.1016/j.eurpsy.2016.01.1470