Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Aladdin Riad"'
Autor:
Ji Youn Lee, Ho Young Kim, Paul Martorano, Aladdin Riad, Michelle Taylor, Robert R. Luedtke, Robert H. Mach
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
IntroductionDopamine D3 receptor (D3R) ligands have been studied for the possible treatment of neurological and neuropsychiatric disorders. However, selective D3R radioligands for in vitro binding studies have been challenging to identify due to the
Externí odkaz:
https://doaj.org/article/749d70c6f3d64d56a3d27ba12f3a01ef
Autor:
Mehran Makvandi, Minu Samanta, Paul Martorano, Hwan Lee, Sarah B. Gitto, Khushbu Patel, David Groff, Jennifer Pogoriler, Daniel Martinez, Aladdin Riad, Hannah Dabagian, Michael Zaleski, Tara Taghvaee, Kuiying Xu, Ji Youn Lee, Catherine Hou, Alvin Farrel, Vandana Batra, Sean D. Carlin, Daniel J. Powell, Robert H. Mach, Daniel A. Pryma, John M. Maris
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-9 (2022)
The efficacy and toxicity of the PARP inhibitor parthanatine, radiolabeled with the alpha particle emitter astatine-211, in 11 patient derived neuroblastoma murine xenografts is investigated.
Externí odkaz:
https://doaj.org/article/39307010894b498daf099e0526685b72
67 Lipid metabolism and synthesis pathway analysis of Sigma-2 Receptor/TMEM97 in breast cancer cells
Publikováno v:
Journal of Clinical and Translational Science, Vol 7, Pp 18-18 (2023)
OBJECTIVES/GOALS: Breast cancer has an increased requirement for lipids. The sigma-2 receptor plays a critical role in the effective uptake of lipoproteins by forming a complex with the LDL Receptor. We investigate the role of the sigma02 receptor in
Externí odkaz:
https://doaj.org/article/086b5fba9548408a804b7ab50fdd9fcc
Autor:
Chi-Chang Weng, Aladdin Riad, Brian P. Lieberman, Kuiying Xu, Xin Peng, John L. Mikitsh, Robert H. Mach
Publikováno v:
Pharmaceuticals, Vol 15, Iss 12, p 1564 (2022)
The sigma-2 receptor/transmembrane protein 97 (σ2R/TMRM97) is a promising biomarker of tumor proliferation and a target for cancer therapy. [3H]DTG has been used to evaluate σ2R/TMEM97 binding affinity in compound development studies. However, [3H]
Externí odkaz:
https://doaj.org/article/7cedcec302664a0ea9e4d9fb10badc65
Exploration of Diazaspiro Cores as Piperazine Bioisosteres in the Development of σ2 Receptor Ligands
Autor:
Kuiying Xu, Chia-Ju Hsieh, Ji Youn Lee, Aladdin Riad, Nicholas J. Izzo, Gary Look, Susan Catalano, Robert H. Mach
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 15, p 8259 (2022)
A series of σ2R compounds containing benzimidazolone and diazacycloalkane cores was synthesized and evaluated in radioligand binding assays. Replacing the piperazine moiety in a lead compound with diazaspiroalkanes and the fused octahydropyrrolo[3,4
Externí odkaz:
https://doaj.org/article/885e6534932e40b1974b435f1678e2ce
Autor:
Chia-Ju Hsieh, Aladdin Riad, Ji Youn Lee, Kristoffer Sahlholm, Kuiying Xu, Robert R. Luedtke, Robert H. Mach
Publikováno v:
Biomolecules, Vol 11, Iss 4, p 529 (2021)
[18F]Fallypride and [18F]Fluortriopride (FTP) are two different PET radiotracers that bind with sub-nanomolar affinity to the dopamine D3 receptor (D3R). In spite of their similar D3 affinities, the two PET ligands display very different properties f
Externí odkaz:
https://doaj.org/article/2e5b88a837b14c0093266e4b72355756
Autor:
Aladdin Riad, Sarah B. Gitto, Hwan Lee, Harrison D. Winters, Paul M. Martorano, Chia-Ju Hsieh, Kuiying Xu, Dalia K. Omran, Daniel J. Powell, Robert H. Mach, Mehran Makvandi
Publikováno v:
Molecules, Vol 25, Iss 24, p 6029 (2020)
Theranostics are emerging as a pillar of cancer therapy that enable the use of single molecule constructs for diagnostic and therapeutic application. As poly adenosine diphosphate (ADP)-ribose polymerase 1 (PARP-1) is overexpressed in various cancer
Externí odkaz:
https://doaj.org/article/b19eeee553f44673aeba1a3c881f1123
Publikováno v:
Cancers, Vol 12, Iss 7, p 1877 (2020)
The sigma-2 receptor was originally defined pharmacologically and recently identified as TMEM97. TMEM97 has been validated as a biomarker of proliferative status and the radioligand of TMEM97, [18F]ISO-1, has been developed and validated as a PET ima
Externí odkaz:
https://doaj.org/article/4fa2f61a1bf749a896f1c416bb0c29d5
Autor:
Bieneke Janssen, Guilong Tian, Zsofia Lengyel-Zhand, Chia-Ju Hsieh, Marshall G. Lougee, Aladdin Riad, Kuiying Xu, Catherine Hou, Chi-Chang Weng, Brian J. Lopresti, Hee Jong Kim, Vinayak V. Pagar, John J. Ferrie, Benjamin A. Garcia, Chester A. Mathis, Kelvin Luk, E. James Petersson, Robert H. Mach
Publikováno v:
Janssen, B, Tian, G, Lengyel-Zhand, Z, Hsieh, C-J, Lougee, M G, Riad, A, Xu, K, Hou, C, Weng, C-C, Lopresti, B J, Kim, H J, Pagar, V V, Ferrie, J J, Garcia, B A, Mathis, C A, Luk, K, Petersson, E J & Mach, R H 2023, ' Identification of a Putative α-synuclein Radioligand Using an in silico Similarity Search ', Molecular Imaging and Biology, vol. 25, no. 4, pp. 704-719 . https://doi.org/10.1007/s11307-023-01814-9
Molecular Imaging and Biology. Springer New York
Molecular Imaging and Biology. Springer New York
Purpose: Previous studies from our lab utilized an ultra-high throughput screening method to identify compound 1 as a small molecule that binds to alpha-synuclein (α-synuclein) fibrils. The goal of the current study was to conduct a similarity searc
Autor:
Ho Young Kim, Ji Youn Lee, Chia-Ju Hsieh, Aladdin Riad, Nicholas J. Izzo, Susan M. Catalano, Thomas J. A. Graham, Robert H. Mach
Publikováno v:
Journal of Medicinal Chemistry. 65:6261-6272