Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Alacoque Browne"'
Autor:
Neil T Conlon, Sandra Roche, Amira F Mahdi, Alacoque Browne, Laura Breen, Johanna Gaubatz, Justine Meiller, Fiona O'Neill, Lorraine O'Driscoll, Mattia Cremona, Bryan T Hennessy, Lisa D Eli, John Crown, Denis M Collins
Publikováno v:
Translational Oncology, Vol 49, Iss , Pp 102073- (2024)
Background: HER2-targeted therapies have revolutionised the treatment of HER2-positive breast cancer. However, de novo resistance or the emergence of acquired resistance is a persistent clinical problem. Here we report that neratinib, an irreversible
Externí odkaz:
https://doaj.org/article/80c2e8e9bf2e4172bafb263c57f5769f
Autor:
Nupur Mukherjee, Alacoque Browne, Laura Ivers, Tapesh Santra, Mattia Cremona, Bryan T. Hennessy, Norma O’Donovan, John Crown, Walter Kolch, Dirk Fey, Alex J. Eustace
Publikováno v:
Journal of Personalized Medicine; Volume 12; Issue 8; Pages: 1277
Triple negative breast cancer (TNBC) remains a therapeutic challenge due to the lack of targetable genetic alterations and the frequent development of resistance to the standard cisplatin-based chemotherapies. Here, we have taken a systems biology ap
Autor:
Alex J Eustace, N. Gaynor, Stephen F. Madden, Joanna Fay, Denis M. Collins, Elaine W. Kay, Sinead Toomey, Alacoque Browne, John Crown, Bryan T. Hennessy, Katherine M. Sheehan, William M. Gallagher
Publikováno v:
Cancer Research. 80:P1-10
Background: Increased tumour infiltrating lymphocytes (TILs) are associated with a better prognosis in HER2+ BC patients treated with neo-adjuvant chemotherapy. The signalling mechanisms associated with increased TIL levels are not fully understood.
Autor:
Lance Hudson, Nicola Cosgrove, Alacoque Browne, Arnold D.K. Hill, Fiona T Bane, Elspeth Ward, Ailis Fagan, Sinead Cocchiglia, Siobhan Purcell, Damir Varešlija, Jason S. Carroll, Sara Charmsaz, Leonie S. Young, Aisling M. Redmond
Publikováno v:
Oncogene
Steroid receptor coactivator 1 (SRC-1) interacts with nuclear receptors and other transcription factors (TFs) to initiate transcriptional networks and regulate downstream genes which enable the cancer cell to evade therapy and metastasise. Here we to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::977b4243b38e1cefc028afdafb65a076
https://www.repository.cam.ac.uk/handle/1810/289888
https://www.repository.cam.ac.uk/handle/1810/289888
Autor:
Arnold D.K. Hill, Siobhan Purcell, Nicola Cosgrove, Alacoque Browne, Elspeth Ward, Sudipto Das, Damir Varešlija, Andrew H. Sims, Leonie S. Young, Sinead Cocchiglia, Phillip J O'Halloran, Ailis Fagan, Sara Charmsaz, Lance Hudson, Darran P. O'Connor
Publikováno v:
Ward, E, Vareslija, D, Charmsaz, S, Fagan, A, Browne, A L, Cosgrove, N, Cocchiglia, S, Purcell, S, Hudson, L, Das, S, O'Connor, D, O'Halloran, P J, Sims, A H, Hill, A D & Young, L S 2018, ' Epigenome-wide SRC-1 mediated gene silencing represses cellular differentiation in advanced breast cancer ', Clinical Cancer Research . https://doi.org/10.1158/1078-0432.CCR-17-2615
Purpose: Despite the clinical utility of endocrine therapies for estrogen receptor–positive (ER) breast cancer, up to 40% of patients eventually develop resistance, leading to disease progression. The molecular determinants that drive this adaptati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed0dc88036138ddca0f60d24cf9bce87
https://hdl.handle.net/20.500.11820/7bce31e9-f8cb-4587-9739-69ba75dd05c9
https://hdl.handle.net/20.500.11820/7bce31e9-f8cb-4587-9739-69ba75dd05c9
Autor:
Mona El-Bahrawy, Alacoque Browne, Radhika Aiyappa, Nesreen Magdy, Senthuran Jeyapalan, Camila H. de Sousa, Hani Gabra, Ruethairat Sriraksa, Euan A. Stronach, Tankut G. Guney, Christina Turner, Paula Cunnea, James B. Studd
Publikováno v:
Oncotarget
Platinum based drugs are the cornerstone of chemotherapy for ovarian cancer, however the development of chemoresistance hinders its success. IL-8 is involved in regulating several pro-survival pathways in cancer. We studied the expression of IL-8 and
Publikováno v:
Cancer Research. 77:P3-04
Cancer cells undergo dynamic and frequently reversible modifications and this cellular plasticity permits reprogramming in response to long term endocrine treatment. A well-established theory, the cancer stem cell theory; suggests that within an ER p
Publikováno v:
BMC Proceedings
Background The issue of acquired resistance to breast cancer regimes such as tamoxifen continues to negatively affect clinical outcomes. While many mechanisms of resistance have been discovered [1,2], there is evidence now of acquired resistance thro
Autor:
Nicola Cosgrove, Damir Varešlija, Elspeth Ward, Leonie S. Young, Ailis Fagan, Alacoque Browne
Publikováno v:
Cancer Research. 77:5631-5631
Despite the clinical benefit in treating ER positive breast cancer, hormone therapy resistance occurs in 40% patients leading to disease progression. Steroid receptor co-activator 1 (SRC1) enhances target gene transcription and has a critical role in