Výsledky vyhledávání - "Alaa Talhami"

Akademický článek

Cyclizing Painkillers: Development of Backbone-Cyclic TAPS Analogs

Autor: Alaa Talhami, Avi Swed, Shmuel Hess, Oded Ovadia, Sarit Greenberg, Adi Schumacher-Klinger, David Rosenthal, Deborah E. Shalev, Mattan Hurevich, Philip Lazarovici, Amnon Hoffman, Chaim Gilon

Publikováno v: Frontiers in Chemistry, Vol 8 (2020)

Painkillers are commonly used medications. Native peptide painkillers suffer from various pharmacological disadvantages, while small molecule painkillers like morphine are highly addictive. We present a general approach aimed to use backbone-cyclizat

Externí odkaz: https://doaj.org/article/214c0a356de24363ad9340767112adf5

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PSMA-targeted polyinosine/polycytosine vector induces prostate tumor regression and invokes an antitumor immune response in mice

Autor: Salim Joubran, Alexander Levitzki, Nufar Edinger, Anna Sagalov, Yael Langut, Shoshana Klein, Efrat Flashner-Abramson, Samarasimhareddy Mamidi, Alexei Shir, Maya Zigler, Alaa Talhami

Publikováno v: Proceedings of the National Academy of Sciences. 114:13655-13660

There is an urgent need for an effective treatment for metastatic prostate cancer (PC). Prostate tumors invariably overexpress prostate surface membrane antigen (PSMA). We designed a nonviral vector, PEI-PEG-DUPA (PPD), comprising polyethylenimine-po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a57aac7ec0d9b914957bf29b61a76e94
https://doi.org/10.1073/pnas.1714587115

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Development of a Novel Backbone Cyclic Peptide Inhibitor of the Innate Immune TLR/IL1R Signaling Protein MyD88

Autor: Ibrahim Kassis, Gabriel Nussbaum, Chaim Gilon, Adi Schumacher, Joseph Fanous, Amnon Hoffman, Alaa Talhami, Shira Dishon, Dimitrios Karussis

Publikováno v: Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)

MyD88 is a cytoplasmic adaptor protein that plays a central role in signaling downstream of the TLRs and the IL1R superfamily. We previously demonstrated that MyD88 plays a critical role in EAE, the murine model of multiple sclerosis, and showed that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f6b432970e784eda88c70d9e6da252a
https://doi.org/10.1038/s41598-018-27773-8

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Sol–gel entrapped dichlorobis(triphenylphosphine)palladium as an efficient recyclable catalyst for the cross-coupling of aryl halides with indium- and related alkylating reagents

Autor: Liza Penn, Jochanan Blum, Alaa Talhami, Nimer Jaber, Khalil Hamza

Publikováno v: Applied Catalysis A: General. 312:115-119

Physically entrapped dichlorobis(triphenylphosphine)palladium(II) within a silica sol–gel matrix is an efficient catalyst for cross-coupling of aryl iodides, bromides and triflates with intramolecularly stabilized dimethyl- and diethylindium alkyla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2ec987be91f28f1071a98a0ce426bb7d
https://doi.org/10.1016/j.apcata.2006.06.033

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Allosteric inhibition of g-protein coupled receptor oligomerization: strategies and challenges for drug development

Autor: Deborah E. Shalev, Chaim Gilon, Alaa Talhami, Mattan Hurevich

Publikováno v: Current topics in medicinal chemistry. 14(15)

G-protein coupled receptors (GPCRs) mediate a large number of biological pathways and are major therapeutic targets. One of the most exiting phenomena of GPCRs is their ability to interact with other GPCRs. GPCRGPCR interactions, also known as GPCR o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3816807c639bb6c1da96627fe2e3aad2
https://pubmed.ncbi.nlm.nih.gov/25175995

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