Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Alaa M, Hayallah"'
Autor:
Hamada H. H. Mohammed, Amer Ali Abd El-Hafeez, Kareem Ebeid, Aml I. Mekkawy, Mohammed A. S. Abourehab, Emad I. Wafa, Suhaila O. Alhaj-Suliman, Aliasger K. Salem, Pradipta Ghosh, Gamal El-Din A. Abuo-Rahma, Alaa M. Hayallah, Samar H. Abbas
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 1346-1363 (2022)
A series of novel 1,2,3-triazole-linked ciprofloxacin-chalcones 4a-j were synthesised as potential anticancer agents. Hybrids 4a-j exhibited remarkable anti-proliferative activity against colon cancer cells. Compounds 4a-j displayed IC50s ranged from
Externí odkaz:
https://doaj.org/article/606a96ca25cb42d88708edc3b4fecfee
Autor:
Lamya H. Al-Wahaibi, Mohamed Hisham, Hesham A. Abou-Zied, Heba A. Hassan, Bahaa G. M. Youssif, Stefan Bräse, Alaa M. Hayallah, Mohamed Abdel-Aziz
Publikováno v:
Pharmaceuticals, Vol 16, Iss 11, p 1522 (2023)
A novel series of hybrid compounds comprising quinazolin-4-one and 3-cyanopyridin-2-one structures has been developed, with dual inhibitory actions on both EGFR and BRAFV600E. These hybrid compounds were tested in vitro against four different cancer
Externí odkaz:
https://doaj.org/article/58fc1dca95434f25acd7ae4f3ad765aa
Autor:
Lamya H. Al-Wahaibi, Hesham A. Abou-Zied, Mohamed Hisham, Eman A. M. Beshr, Bahaa G. M. Youssif, Stefan Bräse, Alaa M. Hayallah, Mohamed Abdel-Aziz
Publikováno v:
Molecules, Vol 28, Iss 18, p 6586 (2023)
A series of novel 3-cyanopyridone/pyrazoline hybrids (21–30) exhibiting dual inhibition against EGFR and BRAFV600E has been developed. The synthesized target compounds were tested in vitro against four cancer cell lines. Compounds 28 and 30 demonst
Externí odkaz:
https://doaj.org/article/8e35e01c62b4478c8c7b1482c29ab904
Autor:
Mohamed A. Abdelgawad, Alaa M. Hayallah, Syed Nasir Abbas Bukhari, Arafa Musa, Mohammed Elmowafy, Hamdy M. Abdel-Rahman, Mohammed K. Abd El-Gaber
Publikováno v:
Pharmaceuticals, Vol 15, Iss 11, p 1416 (2022)
A new series of indoline-2-one derivatives was designed and synthesized based on the essential pharmacophoric features of VEGFR-2 inhibitors. Anti-proliferative activities were assessed for all derivatives against breast (MCF-7) and liver (HepG2) can
Externí odkaz:
https://doaj.org/article/a92b22ea54d94fde83d75b04816139da
Autor:
Soad A. Mohamed, Mohamed A. Abdelgawad, Rania Alaaeldin, Zeinab Fathalla, Hossam Moharram, Raafat M. A. Abdallah, Islam M. Abdel-Rahman, Mohamed Abdel-Aziz, Gamal El-Din A. Abuo-Rahma, Mohammed M. Ghoneim, Alaa M. Hayallah, Mahmoud Elrehany, Hamdy Abdelkader
Publikováno v:
Pharmaceuticals, Vol 15, Iss 1, p 44 (2021)
Keratitis is a global health issue that claims the eye sight of millions of people every year. Dry eye, contact lens wearing and refractive surgeries are among the most common causes. The resistance rate among fluoroquinolone antibiotics is >30%. Thi
Externí odkaz:
https://doaj.org/article/425aad54ad8d4ef384da62638b639d60
Autor:
Ayman M. Ibrahim, Mai E. Shoman, Mamdouh F. A. Mohamed, Alaa M. Hayallah, Gamal El‐Din A. Abuo‐Rahma
Publikováno v:
European Journal of Organic Chemistry. 26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea7eb10860ae64e1e1fb527a88c7af0d
https://doi.org/10.1002/ejoc.202300184
https://doi.org/10.1002/ejoc.202300184
Autor:
Nourhan Hisham Shady, Alaa M. Hayallah, Mamdouh F. A. Mohamed, Mohammed M. Ghoneim, Garri Chilingaryan, Mohammad M. Al-Sanea, Mostafa A. Fouad, Mohamed Salah Kamel, Usama Ramadan Abdelmohsen
Publikováno v:
Molecules, Vol 26, Iss 12, p 3775 (2021)
Since December 2019, novel coronavirus disease 2019 (COVID-19) pandemic has caused tremendous economic loss and serious health problems worldwide. In this study, we investigated 14 natural compounds isolated from Amphimedon sp. via a molecular dockin
Externí odkaz:
https://doaj.org/article/5d225e9dd144456bae2f8b737f0ec072
Publikováno v:
Pharmacological Reports. 74:570-582
The indole moiety is one of the most widespread heterocycles found in both natural products and biological systems. Indoles have important biological activities including anticancer, antioxidant, anti-inflammatory, antifungal, anticholinesterase, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bf50e3be4261bc3c3c2ed1cec4bd2ed
https://doi.org/10.1007/s43440-022-00370-3
https://doi.org/10.1007/s43440-022-00370-3
Autor:
Reda F. A. Abdelhameed, Eman S. Habib, Nermeen A. Eltahawy, Hashim A. Hassanean, Amany K. Ibrahim, Anber F. Mohammed, Shaimaa Fayez, Alaa M. Hayallah, Koji Yamada, Fathy A. Behery, Mohammad M. Al-Sanea, Sami I. Alzarea, Gerhard Bringmann, Safwat A. Ahmed, Usama Ramadan Abdelmohsen
Publikováno v:
Marine Drugs, Vol 18, Iss 5, p 241 (2020)
Bioactivity-guided isolation supported by LC-HRESIMS metabolic profiling led to the isolation of two new compounds, a ceramide, stylissamide A (1), and a cerebroside, stylissoside A (2), from the methanol extract of the Red Sea sponge Stylissa carter
Externí odkaz:
https://doaj.org/article/6690eb1efe3f4ce6b4c168648b4bacc3
Autor:
Hesham A. Abou‐Zied, Eman A. M. Beshr, Hesham A. M. Gomaa, Yaser A. Mostafa, Bahaa G. M. Youssif, Alaa M. Hayallah, Mohamed Abdel‐Aziz
Publikováno v:
Archiv der Pharmazie. 356
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6900f78bad36417809d118b6c050b60c
https://doi.org/10.1002/ardp.202200464
https://doi.org/10.1002/ardp.202200464