Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Alaa M, Hammad"'
Autor:
Suhair Sunoqrot, Mohammad Abu Shalhoob, Yazun Jarrar, Alaa M. Hammad, Hamzeh J. Al-Ameer, Wajdy Al-Awaida
Publikováno v:
ACS Omega, Vol 9, Iss 7, Pp 7881-7890 (2024)
Externí odkaz:
https://doaj.org/article/e97c463cc41c4c048b38c3f647664969
Publikováno v:
Toxics, Vol 12, Iss 8, p 598 (2024)
Repeated exposure to tobacco smoke causes neuroinflammation and neuroplasticity, which correlates with smoking withdrawal-induced anxiety. The purpose of this study was to investigate the anticipated involvement of antioxidant-rich nanoparticles (NPs
Externí odkaz:
https://doaj.org/article/5d411b6257554a3cb9f53a985b07c689
Autor:
Mohammed S. Alasmari, Fawaz Alasmari, Shakir D. Alsharari, Abdullah F. Alasmari, Nemat Ali, Syed Rizwan Ahamad, Abdullah M. Alghamdi, Aban A. Kadi, Alaa M. Hammad, Yousif S. Mohamed Ali, Wayne E. Childers, Magid Abou-Gharbia, Youssef Sari
Publikováno v:
Toxics, Vol 12, Iss 8, p 604 (2024)
Opioid-related deaths are attributed to overdoses, and fentanyl overdose has been on the rise in many parts of the world, including the USA. Glutamate transporter 1 (GLT-1) has been identified as a therapeutic target in several preclinical models of
Externí odkaz:
https://doaj.org/article/f00966e2d097485eb570a59f9dccf2b0
Autor:
Luma Al-Ali, Raad J. Al-Ani, Maysaa M. Saleh, Alaa M. Hammad, Duaa A. Abuarqoub, Bashaer Abu-Irmaileh, Abdallah Y. Naser, Manal M. Najdawi, Manal M. Abbas, Jamal Alyoussef Alkrad
Publikováno v:
Saudi Pharmaceutical Journal, Vol 32, Iss 2, Pp 101931- (2024)
Background: The use of tyrosine kinase inhibitors (TKIs) as a treatment for chronic myeloid leukemia (CML) has improved the natural history of the disease and increased the duration of survival. Tyrosine kinase inhibitors represent the success of tar
Externí odkaz:
https://doaj.org/article/06b69d021fa349e5b849404caefefcc3
Autor:
Balqis A. Ikhmais, Alaa M. Hammad, Osama H. Abusara, Lama Hamadneh, Hamza Abumansour, Qasem M. Abdallah, Ali I. M. Ibrahim, Lina Elsalem, Mariam Awad, Rahaf Alshehada
Publikováno v:
Current Issues in Molecular Biology, Vol 45, Iss 10, Pp 7996-8012 (2023)
Repurposing existing drugs appears to be a potential solution for addressing the challenges in the treatment of non-small cell lung cancer (NSCLC). β-adrenoceptor antagonist drugs (β-blockers) have tumor-inhibiting effects, making them promising ca
Externí odkaz:
https://doaj.org/article/f02a578270174c07bd343311f514c075
Autor:
Suhair Sunoqrot, Malak Alkurdi, Abdel Qader Al Bawab, Alaa M. Hammad, Rabab Tayyem, Ali Abu Obeed, Mohammed Abufara
Publikováno v:
Saudi Pharmaceutical Journal, Vol 31, Iss 6, Pp 845-853 (2023)
Morin (3,5,7,2′,4′-pentahydroxyflavone; MR) is a bioactive plant polyphenol whose therapeutic efficacy is hindered by its poor biopharmaceutical properties. The purpose of this study was to develop a nanoparticle (NP) formulation to enhance the b
Externí odkaz:
https://doaj.org/article/e0ff0138ea6a4fe89a2e864b9595633f
Publikováno v:
Current Issues in Molecular Biology, Vol 45, Iss 3, Pp 2170-2181 (2023)
Aldehyde dehydrogenase (ALDH) enzymes are involved in the growth and development of several tissues, including cancer cells. It has been reported that targeting the ALDH family, including the ALDH1A subfamily, enhances cancer treatment outcomes. Ther
Externí odkaz:
https://doaj.org/article/3a0a7dc7dd4040e4b9e766575fa98fae
Autor:
Maysaa M. Saleh, Duaa A. Abuarqoub, Alaa M. Hammad, Md Shahadat Hossan, Najneen Ahmed, Nazneen Aslam, Abdallah Y. Naser, Christopher J. Moody, Charles A. Laughton, Tracey D. Bradshaw
Publikováno v:
Current Issues in Molecular Biology, Vol 45, Iss 1, Pp 175-196 (2022)
Here, we describe the anticancer activity of our novel bis-triazoles MS47 and MS49, developed previously as G-quadruplex stabilizers, focusing specifically upon the human melanoma MDA-MB-435 cell line. At the National Cancer Institute (NCI), USA, bis
Externí odkaz:
https://doaj.org/article/29394440f6aa4e28ab41123f12ea813e
Autor:
Alaa M. Hammad, Lujain F. Alzaghari, Malek Alfaraj, Walid Al-Qerem, Wamidh H. Talib, Fawaz Alasmari, Haneen Amawi, F. Scott Hall
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2023)
Background: Chronic exposure to cigarette smoke produces neuroinflammation and long-term changes in neurotransmitter systems, especially glutamatergic systems.Objective: We examined the effects of cigarette smoke on astroglial glutamate transporters
Externí odkaz:
https://doaj.org/article/e477f1bafd1a437796d1a9f3ee65baf3
Autor:
Rania Hamed, Wala’a Abu Alata, Mohammad Abu-Sini, Dina H. Abulebdah, Alaa M. Hammad, Rafa Aburayya
Publikováno v:
Gels, Vol 9, Iss 7, p 592 (2023)
Nanoemulsions and bigels are biphasic delivery systems that can be used for topical applications. The aim of this study was to incorporate an oil-in-water ciprofloxacin hydrochloride nanoemulsion (CIP.HCl NE) into two types of bigels, Type I (oleogel
Externí odkaz:
https://doaj.org/article/4f576f3005e540c8808fa40c78b7ad70