Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Alaa H. M. Abdelrahman"'
Autor:
Mahmoud A. A. Ibrahim, Sara S. M. Ali, Khlood A. A. Abdeljawaad, Alaa H. M. Abdelrahman, Gamal A. Gabr, Ahmed M. Shawky, Gamal A. H. Mekhemer, Peter A. Sidhom, Paul W. Paré, Mohamed-Elamir F. Hegazy
Publikováno v:
Journal of Taibah University for Science, Vol 17, Iss 1 (2023)
In the search for new metabolite inhibitors, a natural product activity and species source (NPASS) database was virtually screened using AutoDock software to identify potential NRP1 inhibitors. NPASS compounds complexed with NRP1 were subjected to mo
Externí odkaz:
https://doaj.org/article/220d62db63ee48d4affea6ff1e339d03
Autor:
Mahmoud A. A. Ibrahim, Khlood A. A. Abdeljawaad, Eslam Roshdy, Dina E. M. Mohamed, Taha F. S. Ali, Gamal A. Gabr, Laila A. Jaragh-Alhadad, Gamal A. H. Mekhemer, Ahmed M. Shawky, Peter A. Sidhom, Alaa H. M. Abdelrahman
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract Sirtuin 2 (SIRT2) is a member of the sirtuin protein family, which includes lysine deacylases that are NAD+-dependent and organize several biological processes. Different forms of cancer have been associated with dysregulation of SIRT2 activ
Externí odkaz:
https://doaj.org/article/acf4d8428b04434989e4c8b794a5edda
Autor:
Mahmoud A. A. Ibrahim, Mahmoud M. H. Abdelhamid, Khlood A. A. Abdeljawaad, Alaa H. M. Abdelrahman, Gamal A. H. Mekhemer, Peter A. Sidhom, Shaban R. M. Sayed, Paul W. Paré, Mohamed-Elamir F. Hegazy, Tamer Shoeib
Publikováno v:
Molecules, Vol 28, Iss 15, p 5713 (2023)
BRD4 (bromodomain-containing protein 4) is an epigenetic reader that realizes histone proteins and promotes the transcription of genes linked to cancer progression and non-cancer diseases such as acute heart failure and severe inflammation. The highl
Externí odkaz:
https://doaj.org/article/5a6c107947b948349a0ca2b761d038bb
Autor:
Mahmoud A. A. Ibrahim, Khlood A. A. Abdeljawaad, Alaa H. M. Abdelrahman, Peter A. Sidhom, Ahmed M. Tawfeek, Gamal A. H. Mekhemer, Mohamed K. Abd El-Rahman, Eslam Dabbish, Tamer Shoeib
Publikováno v:
Pharmaceuticals, Vol 16, Iss 7, p 1019 (2023)
Multidrug resistance (MDR) is one of the most problematic issues in chemotherapeutic carcinoma therapy. The ABCB1 transporter, a drug efflux pump overexpressed in cancer cells, has been thoroughly investigated for its association with MDR. Thus, disc
Externí odkaz:
https://doaj.org/article/7e5037ee26d54f91b9400d8ba459232d
Autor:
Mahmoud A. A. Ibrahim, Alaa H. M. Abdelrahman, Dina E. M. Mohamed, Khlood A. A. Abdeljawaad, Mohamed Ahmed Naeem, Gamal A. Gabr, Ahmed M. Shawky, Mahmoud E. S. Soliman, Peter A. Sidhom, Paul W. Paré, Mohamed-Elamir F. Hegazy
Publikováno v:
Viruses, Vol 15, Iss 1, p 250 (2023)
The emergence of the Coronavirus Disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has led to over 6 million deaths. The 3C-like protease (3CLpro) enzyme of the SARS-CoV-2 virus is an attractive d
Externí odkaz:
https://doaj.org/article/9b889d0689364673945ed2c575f1957b
Autor:
Mahmoud A. A. Ibrahim, Khlood A. A. Abdeljawaad, Alaa H. M. Abdelrahman, Laila A. Jaragh-Alhadad, Hesham Farouk Oraby, Eslam B. Elkaeed, Gamal A. H. Mekhemer, Gamal A. Gabr, Ahmed M. Shawky, Peter A. Sidhom, Mahmoud E. S. Soliman, Mahmoud F. Moustafa, Paul W. Paré, Mohamed-Elamir F. Hegazy
Publikováno v:
Molecules, Vol 27, Iss 10, p 3104 (2022)
The P-glycoprotein (P-gp/ABCB1) is responsible for a xenobiotic efflux pump that shackles intracellular drug accumulation. Additionally, it is included in the dud of considerable antiviral and anticancer chemotherapies because of the multidrug resist
Externí odkaz:
https://doaj.org/article/b6b8fd0ec3d84771a4c55113a5e63a9d
Autor:
Mahmoud A. A. Ibrahim, Alaa H. M. Abdelrahman, Laila A. Jaragh-Alhadad, Mohamed A. M. Atia, Othman R. Alzahrani, Muhammad Naeem Ahmed, Moustafa Sherief Moustafa, Mahmoud E. S. Soliman, Ahmed M. Shawky, Paul W. Paré, Mohamed-Elamir F. Hegazy, Peter A. Sidhom
Publikováno v:
Pharmaceuticals, Vol 15, Iss 2, p 153 (2022)
The main protease (Mpro) is a potential druggable target in SARS-CoV-2 replication. Herein, an in silico study was conducted to mine for Mpro inhibitors from toxin sources. A toxin and toxin-target database (T3DB) was virtually screened for inhibitor
Externí odkaz:
https://doaj.org/article/ca1bac097b004b5c8cd717670f8a4882
Autor:
Mahmoud A. A. Ibrahim, Khlood A. A. Abdeljawaad, Alaa H. M. Abdelrahman, Othman R. Alzahrani, Fahad M. Alshabrmi, Esraa Khalaf, Mahmoud F. Moustafa, Faris Alrumaihi, Khaled S. Allemailem, Mahmoud E. S. Soliman, Paul W. Paré, Mohamed-Elamir F. Hegazy, Mohamed A. M. Atia
Publikováno v:
Antibiotics, Vol 10, Iss 8, p 934 (2021)
Penicillin-binding proteins (PBPs) catalyze the final stages for peptidoglycan cell-wall bio-synthesis. Mutations in the PBP2a subunit can attenuate β-lactam antibiotic activity, resulting in unimpeded cell-wall formation and methicillin-resistant S
Externí odkaz:
https://doaj.org/article/74fc6dc8aba64b78bd912c4a5f39d81a
Autor:
Mahmoud A. A. Ibrahim, Alaa H. M. Abdelrahman, Mohamed A. M. Atia, Tarik A. Mohamed, Mahmoud F. Moustafa, Abdulrahim R. Hakami, Shaden A. M. Khalifa, Fahad A. Alhumaydhi, Faris Alrumaihi, Syed Hani Abidi, Khaled S. Allemailem, Thomas Efferth, Mahmoud E. Soliman, Paul W. Paré, Hesham R. El-Seedi, Mohamed-Elamir F. Hegazy
Publikováno v:
Marine Drugs, Vol 19, Iss 7, p 391 (2021)
The coronavirus pandemic has affected more than 150 million people, while over 3.25 million people have died from the coronavirus disease 2019 (COVID-19). As there are no established therapies for COVID-19 treatment, drugs that inhibit viral replicat
Externí odkaz:
https://doaj.org/article/084dd42a16de4625a4d77ef61047ac6e
Autor:
Mahmoud A. A. Ibrahim, Alaa H. M. Abdelrahman, Tarik A. Mohamed, Mohamed A. M. Atia, Montaser A. M. Al-Hammady, Khlood A. A. Abdeljawaad, Eman M. Elkady, Mahmoud F. Moustafa, Faris Alrumaihi, Khaled S. Allemailem, Hesham R. El-Seedi, Paul W. Paré, Thomas Efferth, Mohamed-Elamir F. Hegazy
Publikováno v:
Molecules, Vol 26, Iss 7, p 2082 (2021)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent for the COVID-19 pandemic, which generated more than 1.82 million deaths in 2020 alone, in addition to 83.8 million infections. Currently, there is no antiviral medic
Externí odkaz:
https://doaj.org/article/6c010b4c3ef74c72acfe7cb2c013bde7