Zobrazeno 1 - 10
of 190
pro vyhledávání: '"Alaa A.-M. Abdel-Aziz"'
Autor:
Sultan Z. Alasmari, Mohammed H. Makkawi, Irfan Ahmad, Abdulrahim R. Hakami, Abdulrahman A. Almehizia, Adel S. El-Azab, Alaa A.-M. Abdel-Aziz, Mohammed Ghazwani
Publikováno v:
Journal of King Saud University: Science, Vol 36, Iss 8, Pp 103316- (2024)
Background: Evaluating the effectiveness of a specific quinazoline molecule with antibacterial activity on microorganisms as a potential antibiotic substitution. Methods: A variety of microorganisms were tested with the designated quinazoline molecul
Externí odkaz:
https://doaj.org/article/11c64fc12e294b4eb4299ef55c303be2
Autor:
Adel S. El-Azab, Alaa A.-M. Abdel-Aziz, Silvia Bua, Alessio Nocentini, Ahmed H. Bakheit, Hamad M. Alkahtani, Mohamed M. Hefnawy, Claudiu T. Supuran
Publikováno v:
Saudi Pharmaceutical Journal, Vol 31, Iss 12, Pp 101866- (2023)
In this study, The inhibitory actions of human carbonic anhydrase (CA, EC 4.2.1.1) (hCA) isoforms I, II, IX, and XII are being examined using recently synthesized substituted hydroxyl Schiff derivatives based on the quinazoline scaffold 4–22. Quina
Externí odkaz:
https://doaj.org/article/1b543ab78ca8435c914ea8a96d403b3f
Autor:
Dina I.A. Othman, Abdelrahman Hamdi, Walaa M. Elhusseiny, Adel S. El-Azab, Ahmed H. Bakheit, Mohamed Hefnawy, Alaa A.-M. Abdel-Aziz
Publikováno v:
Saudi Pharmaceutical Journal, Vol 31, Iss 11, Pp 101803- (2023)
Spirochromanes incorporating Schiff's bases and semicarbazones 4a-e and 5a-j were synthesizedand analyzed for their potential antiproliferative activity using four human cancer cell lines (MCF-7, HCT-116, PC3, and A549). Compounds 5a, 5b and 5g posse
Externí odkaz:
https://doaj.org/article/4e5c3903315b4d37ba6fe518806d11e8
Publikováno v:
Molecules, Vol 28, Iss 17, p 6428 (2023)
Two series of pyrazolo[3,4-b]pyridine derivatives, 9a–h and 14a–h, are synthesized and evaluated for their anti-cancer potency towards Hela, MCF7, and HCT-116 cancer cell lines. Compound 9a showed the highest anticancer activity with IC50 = 2.59
Externí odkaz:
https://doaj.org/article/1f6ed2cefb6f462bac0172b10b334863
Autor:
Alaa A.-M. Abdel-Aziz, Adel S. El-Azab, Nawaf A. AlSaif, Ahmad J. Obaidullah, Abdulrahman M. Al-Obaid, Ibrahim A. Al-Suwaidan
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1520-1538 (2021)
Hydrazone is a bioactive pharmacophore that can be used to design antitumor agents. We synthesised a series of hydrazones (compounds 4–24) incorporating a 4-methylsulfonylbenzene scaffold and analysed their potential antitumor activity. Compounds 6
Externí odkaz:
https://doaj.org/article/f2cef13a3c0140699e1966145b1894a6
Autor:
Salma Fares, Khalid B. Selim, Fatma E. Goda, Magda A. A. El-Sayed, Nawaf A. AlSaif, Mohamed M. Hefnawy, Alaa A.-M. Abdel-Aziz, Adel S. El-Azab
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1487-1498 (2021)
New cyanobenzofurans derivatives 2–12 were synthesised, and their antiproliferative activity was examined compared to doxorubicin and Afatinib (IC50 = 4.17–8.87 and 5.5–11.2 µM, respectively). Compounds 2 and 8 exhibited broad-spectrum activit
Externí odkaz:
https://doaj.org/article/19de139e6b954a888b332ef01aceb363
Autor:
Alaa A.-M. Abdel-Aziz, Adel S. El-Azab, Nawaf A. AlSaif, Mohammed M. Alanazi, Manal A. El-Gendy, Ahmad J. Obaidullah, Hamad M. Alkahtani, Abdulrahman A. Almehizia, Ibrahim A. Al-Suwaidan
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 610-621 (2020)
Cyclic imides containing 3-benzenesulfonamide, oxime, and β-phenylalanine derivatives were synthesised and evaluated to elucidate their in vivo anti-inflammatory and ulcerogenic activity and in vitro cytotoxic effects. Most active anti-inflammatory
Externí odkaz:
https://doaj.org/article/29c41b55f7f44ad58bbdbb2972f136e0
Autor:
Adel S. El-Azab, Alaa A.-M. Abdel-Aziz, Silvia Bua, Alessio Nocentini, Nawaf A. AlSaif, Mohammed M. Alanazi, Manal A. El-Gendy, Hany E. A. Ahmed, Claudiu T. Supuran
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 733-743 (2020)
We evaluated the hCA (CA, EC 4.2.1.1) inhibitory activity of novel 4-(2-(2-substituted-thio-4-oxoquinazolin-3(4H)-yl)ethyl)benzenesulfonamides (compounds 2–20) towards the isoforms I, II, IX, and XII. hCA Isoforms were effectively inhibited by most
Externí odkaz:
https://doaj.org/article/38716572624e4b48996a19381f48b25d
Autor:
Adel S. El-Azab, Alaa A.-M. Abdel-Aziz, Hany E. A. Ahmed, Sivia Bua, Alessio Nocentini, Nawaf A. AlSaif, Ahmad J. Obaidullah, Mohamed M. Hefnawy, Claudiu T. Supuran
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 598-609 (2020)
Inhibitory action of newly synthesised 4-(2-(2-substituted-thio-4-oxoquinazolin-3(4H)-yl)ethyl)benzenesulfonamides compounds 2–13 against human carbonic anhydrase (CA, EC 4.2.1.1) (hCA) isoforms I, II, IX, and XII, was evaluated. hCA I was efficien
Externí odkaz:
https://doaj.org/article/c29c31e8ad2a48d699922a94da505129
Autor:
Walaa M. El-Husseiny, Magda A.-A. El-Sayed, Adel S. El-Azab, Nawaf A. AlSaif, Mohammed M. Alanazi, Alaa A.-M. Abdel-Aziz
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 744-758 (2020)
A series of 24 compounds was synthesised based on a 2-cyclopentyloxyanisole scaffold 3–14 and their in vitro antitumor activity was evaluated. Compounds 4a, 4b, 6b, 7b, 13, and 14 had the most potent antitumor activity (IC50 range: 5.13–17.95 μM
Externí odkaz:
https://doaj.org/article/ed125ec221f64f458687e296b06c3dc3