Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Alaa A. El-Tombary"'
Autor:
Marwa M. Abu-Serie, Alaa A. El-Tombary, S. A. Shams El-Dine, Heba A. Abd El Razik, Omaima G. Shaaban, Fawzia A. Ashour, Ola S. Afifi
Publikováno v:
Bioorganic Chemistry. 87:821-837
Novel purine-pyrazole hybrids combining thiazoles, thiazolidinones and rhodanines, were designed and tested as 15-LOX inhibitors, potential anticancer and antioxidant agents. All tested compounds were found to be potent 15-LOX inhibitors with IC50 ra
Autor:
Alaa A. El-Tombary, Perihan A. Elzahhar, Ibrahim M. El-Ashmawy, Salwa Elkazaz, Soad A.M. El-Hawash, Hossam A. Shaltout, Abeer E. Abdel Wahab, Raafat Soliman
Publikováno v:
Future Medicinal Chemistry. 9:1413-1450
Aim: Inflammation may cause accumulation of fluid in the injured area, which may promote bacterial growth. Other reports disclosed that non-steroidal anti-inflammatory drugs may enhance progression of bacterial infection. Results: This work describes
Autor:
Alaa A. El-Tombary, Abeer E. Abdel Wahab, Ibrahim A. Abdelwahab, Omaima G. Shaaban, Doaa A. E. Issa, Shrouk M. Abd El Wahab
Publikováno v:
Bioorganic chemistry. 88
In continuation of our research program aiming at developing new potent antimicrobial agents, new series of substituted 3,4-dihydrothieno[2,3-d]pyrimidines was synthesized. The newly synthesized compounds were preliminary tested for their in vitro ac
Autor:
S. A. Shams El-Dine, Fawzia A. Ashour, Ola S. Afifi, Omaima G. Shaaban, Alaa A. El-Tombary, Marwa M. Abu-Serie, Heba A. Abd El Razik
Publikováno v:
Future medicinal chemistry. 10(12)
Aim: Targeting apoptosis regulators such as caspases aiming at inducing apoptosis is an attractive strategy in cancer therapy. Materials & methods: 8-substituted purine incorporating pyrazole moiety were designed, synthesized and evaluated for their
Publikováno v:
Medicinal Chemistry Research. 22:3289-3308
The present study is concerned with the synthesis, anticancer and antimicrobial screening of several new 3-substituted or 2,3-disubstituted-5-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxamide derivatives. Three compounds (4b, 8c, and 11b)
Autor:
Yasser S. Abdel-Ghany, Alaa A. El-Tombary, Farid S. G. Soliman, S. A. Shams El-Dine, Ahmad S. F. Belal
Publikováno v:
Medicinal Chemistry Research. 20:865-876
In search for novel anti-cancer and anti-microbial agents with promising pharmacotoxicological profile, the synthesis of some substituted 4-halofuran-2(5H)-ones (8a–l, 9, 11) and derived halogenated quinoxalin-2(1H)-ones (12a–d) is described. Som
Publikováno v:
Medicinal chemistry (Shariqah (United Arab Emirates)). 10(5)
The present investigation describes the synthesis of a new series of aldehydo-sugar-N-(3-phenylquinoxalin-2- yl)hydrazones 3a-d and their acyclic C-nucleoside analogs, 1-(4-phenyl-[1,2,4]triazolo[4,3-a]quinoxalin-1-yl)alditols 7ad by using 2-hydrazin
Autor:
Alaa A. El-Tombary
Publikováno v:
Scientia Pharmaceutica
Volume 81
Issue 2
Pages 393-422
Volume 81
Issue 2
Pages 393-422
In the present investigation, some new pyrazolo[3,4-d]pyrimidin-4(5H)-one derivatives (7-12) as well as fused pyrazolo[3',4':4,5]pyrimido[1,2-b]pyridazin-4(1H)-one (14-16) and 7,8,9,10-tetrahydropyrazolo[3',4':4,5]pyrimido[1,2-b]-cinnolin-4(1H)-one (
Publikováno v:
Archiv der Pharmazie. 329:433-437
A series of steroidal 1,4-diketone derivatives was synthesized by acid-catalyzed condensation of 2-acetylestradiol-17 beta-acetate with substituted phenylglyoxals. Conversion of the products into the corresponding pyridazine derivatives was achieved
Publikováno v:
European Journal of Medicinal Chemistry. 30:423-427
Summary The preparation and characterization of some novel 2-(pyrimidin-4-yl)estradiol derivatives are presented. The synthesis was achieved by the reaction of 2-benzoylacetylestradiol 17β-acetate with guanidines, urea, thiourea and a variety of thi