First crystal structures of 1-deoxy-d-xylulose 5-phosphate synthase (DXPS) from Mycobacterium tuberculosis indicate a distinct mechanism of intermediate stabilization

Autor: Robin M. Gierse, Rick Oerlemans, Eswar R. Reddem, Victor O. Gawriljuk, Alaa Alhayek, Dominik Baitinger, Harald Jakobi, Bernd Laber, Gudrun Lange, Anna K. H. Hirsch, Matthew R. Groves

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)

Abstract The development of drug resistance by Mycobacterium tuberculosis and other pathogenic bacteria emphasizes the need for new antibiotics. Unlike animals, most bacteria synthesize isoprenoid precursors through the MEP pathway. 1-Deoxy-d-xylulos

Externí odkaz: https://doaj.org/article/2b8bfdc100064a6dbd3b456cb371d4e2

Structure-Based Design of α-Substituted Mercaptoacetamides as Inhibitors of the Virulence Factor LasB from Pseudomonas aeruginosa

Autor: Cansu Kaya, Isabell Walter, Alaa Alhayek, Roya Shafiei, Gwenaëlle Jézéquel, Anastasia Andreas, Jelena Konstantinović, Esther Schönauer, Asfandyar Sikandar, Jörg Haupenthal, Rolf Müller, Hans Brandstetter, Rolf W. Hartmann, Anna K.H. Hirsch

Publikováno v: ACS Infectious Diseases. 8:1010-1021

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8e0cc9f4ee20ede994b9052aeda07de0
https://doi.org/10.1021/acsinfecdis.1c00628

Phosphonate as a Stable Zinc‐Binding Group for 'Pathoblocker' Inhibitors of Clostridial Collagenase H (ColH)

Autor: Rolf Müller, Hans Brandstetter, Rolf W. Hartmann, Anastasia Andreas, Esther Schönauer, Christian Ducho, Jörg Haupenthal, Alaa Alhayek, Anna K. H. Hirsch, Katrin Voos

Publikováno v: Chemmedchem

Microbial infections are a significant threat to public health, and resistance is on the rise, so new antibiotics with novel modes of action are urgently needed. The extracellular zinc metalloprotease collagenase H (ColH) from Clostridium histolyticu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd3fac8bdb4f44b6c26b1f5fd2b58304
http://europepmc.org/articles/PMC8251769

N-Aryl-2-iso-butylmercaptoacetamides: the discovery of highly potent and selective inhibitors of Pseudomonas aeruginosa virulence factor LasB and Clostridium histolyticum virulence factor ColH

Autor: Katrin Voos, Samir Yahiaoui, Jelena Konstantinović, Esther Schönauer, Alaa Alhayek, Asfandyar Sikandar, Khadidja Si Chaib, Tizian Ramspoth, Katharina Rox, Jörg Haupenthal, Jesko Köhnke, Hans Brandstetter, Christian Ducho, Anna Hirsch

Antimicrobial resistance is currently one of the serious global public health threats. Unlike the conventional antimicrobial drugs, antivirulence agents disarm rather than kill bacterial pathogens and therefore represent an alternative option to skir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7b0b32de960b308489b21a3d4049a796
https://doi.org/10.26434/chemrxiv-2022-fjrqr

Protein‐Templated Hit Identification through an Ugi Four‐Component Reaction**

Autor: Jennifer Herrmann, Rolf Müller, Alaa Alhayek, Peer Lukat, Varsha R. Jumde, Wulf Blankenfeldt, M. Yagiz Unver, Matthias Köck, Martin D. Witte, Walid A. M. Elgaher, Federica Mancini, Anna K. H. Hirsch

Publikováno v: Chemistry (Weinheim an Der Bergstrasse, Germany)
Chemistry (Weinheim an der Bergstrasse, Germany)
Germany
Chemistry – A European Journal
Chemistry-A European Journal, 26(64), 14585-14593. Wiley-VCH Verlag GmbH & Co. KGaA

Kinetic target‐guided synthesis represents an efficient hit‐identification strategy, in which the protein assembles its own inhibitors from a pool of complementary building blocks via an irreversible reaction. Herein, we pioneered an in situ Ugi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f63ec047fd9b775f368655b848f6624
https://doi.org/10.1002/chem.202002250