Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Alaa, Alachkar"'
Autor:
Alaa Alachkar, Sheikh Azimullah, Mohamed Lotfy, Ernest Adeghate, Shreesh K. Ojha, Rami Beiram, Dorota Łażewska, Katarzyna Kieć-Kononowicz, Bassem Sadek
Publikováno v:
Molecules, Vol 25, Iss 7, p 1575 (2020)
Histamine H3 receptors (H3Rs) are involved in several neuropsychiatric diseases including epilepsy. Therefore, the effects of H3R antagonist E177 (5 and 10 mg/kg, intraperitoneal (i.p.)) were evaluated on the course of kindling development, kindling-
Externí odkaz:
https://doaj.org/article/4ce2c7ec25384ba198d8653948437706
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2017)
The involvement of histamine H3 receptors (H3Rs) in memory is well known, and the potential of H3R antagonists in therapeutic management of neuropsychiatric diseases, e.g., Alzheimer disease (AD) is well established. Therefore, the effects of histami
Externí odkaz:
https://doaj.org/article/e52435f1bbd24c5ba1466cc5c4ac582d
Publikováno v:
Neuropsychiatric Disease and Treatment. 15:531-542
Background Alzheimer disease (AD) is the main cause of dementia in elderly people. The potential of histamine H3 receptor (H3R) antagonists as a pharmacological treatment of several neuropsychiatric diseases is well established. Methods The novel non
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8992b9a7d33fa55231ac6e3e96b0905d
https://doi.org/10.2147/ndt.s193125
https://doi.org/10.2147/ndt.s193125
Autor:
Bassem Sadek, Ernest Adeghate, Katarzyna Kieć-Kononowicz, Alaa Alachkar, Mohamed Lotfy, Dorota Łażewska
Histamine H3 receptors (H3Rs) are involved in several neuropsychiatric diseases including epilepsy. Therefore, the effects of H3R antagonist E177 (5 and 10 mg/kg, intraperitoneal (i.p.)) were evaluated on acute pentylenetetrazole (PTZ)-induced memory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9538105c0cfca8facef84d6c17672f4
https://ruj.uj.edu.pl/xmlui/handle/item/270325
https://ruj.uj.edu.pl/xmlui/handle/item/270325
Autor:
Dorota, Łażewska, Marek, Bajda, Maria, Kaleta, Paula, Zaręba, Agata, Doroz-Płonka, Agata, Siwek, Alaa, Alachkar, Szczepan, Mogilski, Ali, Saad, Kamil, Kuder, Agnieszka, Olejarz-Maciej, Justyna, Godyń, Dorota, Stary, Sylwia, Sudoł, Małgorzata, Więcek, Gniewomir, Latacz, Maria, Walczak, Jadwiga, Handzlik, Bassem, Sadek, Barbara, Malawska, Katarzyna, Kieć-Kononowicz
Publikováno v:
European journal of medicinal chemistry. 207
Design and development of multitarget-directed ligands (MTDLs) has become a very important approach in the search of new therapies for Alzheimer's disease (AD). In our present research, a number of xanthone derivatives were first designed using a pha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::19b9ce0cd6668a224d31e97fea8dca07
https://pubmed.ncbi.nlm.nih.gov/32882609
https://pubmed.ncbi.nlm.nih.gov/32882609
Publikováno v:
Current pharmaceutical design. 26(15)
Epilepsy is a chronic neurological disorder characterized by irregular, excessive neuronal excitability, and recurrent seizures that affect millions of patients worldwide. Currently, accessible antiepileptic drugs (AEDs) do not adequately support all
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60f9fa5dfeb7d37b018eb12817f3c8ad
https://pubmed.ncbi.nlm.nih.gov/32003682
https://pubmed.ncbi.nlm.nih.gov/32003682
Publikováno v:
Neuropsychiatric Disease and Treatment
Background Alzheimer disease (AD) is the main cause of dementia in elderly people. The potential of histamine H3 receptor (H3R) antagonists as a pharmacological treatment of several neuropsychiatric diseases is well established. Methods The novel non
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ff48539f41f9b8496cf064eb47301a89
https://pubmed.ncbi.nlm.nih.gov/30863075
https://pubmed.ncbi.nlm.nih.gov/30863075
Autor:
Dorota Łażewska, Alaa Alachkar, Shreesh Ojha, Sheikh Azimullah, Rami Beiram, Katarzyna Kieć-Kononowicz, Bassem Sadek
Publikováno v:
Molecules
Volume 24
Issue 22
Volume 24
Issue 22
Epilepsy is a multifaceted neurological disorder which severely affects neuronal function. Some patients may experience status epilepticus (SE), a life-threatening state of ongoing seizure activity linked to cognitive dysfunction, necessitating an im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::114dc1ec1475665c62d405b5edbdf8d2
https://ruj.uj.edu.pl/xmlui/handle/item/256591
https://ruj.uj.edu.pl/xmlui/handle/item/256591
Autor:
Maria Walczak, Bassem Sadek, Agata Siwek, Alaa Alachkar, Małgorzata Więcek, Sylwia Sudoł, Marek Bajda, Kamil Kuder, Agnieszka Olejarz-Maciej, Ali Saad, Jadwiga Handzlik, Paula Zaręba, Katarzyna Kieć-Kononowicz, Dorota Stary, Maria Kaleta, Gniewomir Latacz, Barbara Malawska, Dorota Łażewska, Szczepan Mogilski, Agata Doroz-Płonka, Justyna Godyń
Publikováno v:
European Journal of Medicinal Chemistry. 207:112743
Design and development of multitarget-directed ligands (MTDLs) has become a very important approach in the search of new therapies for Alzheimer’s disease (AD). In our present research, a number of xanthone derivatives were first designed using a p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36216f2b4e795b6aa659d8ace76081f8
https://doi.org/10.1016/j.ejmech.2020.112743
https://doi.org/10.1016/j.ejmech.2020.112743
Autor:
Jadwiga Handzlik, Dorota Łażewska, Bassem Sadek, Agata Siwek, Katarzyna Kieć-Kononowicz, Gniewomir Latacz, Annika Frank, Annamaria Lubelska, Ewelina Honkisz-Orzechowska, Alaa Alachkar, Holger Stark
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 19, Iss 11, p 3386 (2018)
Volume 19
Issue 11
International Journal of Molecular Sciences, Vol 19, Iss 11, p 3386 (2018)
Volume 19
Issue 11
A newly developed series of non-imidazole histamine H3 receptor (H3R) antagonists (1&ndash
16) was evaluated in vivo for anticonvulsant effects in three different seizure models in Wistar rats. Among the novel H3R antagonists examined, H3R antag
16) was evaluated in vivo for anticonvulsant effects in three different seizure models in Wistar rats. Among the novel H3R antagonists examined, H3R antag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ead510c19cabbd6d626811e362eec079
https://ruj.uj.edu.pl/xmlui/handle/item/144618
https://ruj.uj.edu.pl/xmlui/handle/item/144618