Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Ala Trusina"'
Autor:
Thomas Holst-Hansen, Pernille Yde Nielsen, Mogens H. Jensen, Thomas Mandrup-Poulsen, Ala Trusina
Publikováno v:
npj Systems Biology and Applications, Vol 10, Iss 1, Pp 1-13 (2024)
Abstract Type 2 diabetes (T2D) is associated with a systemic increase in the pro-inflammatory cytokine IL-1β. While transient exposure to low IL-1β concentrations improves insulin secretion and β-cell proliferation in pancreatic islets, prolonged
Externí odkaz:
https://doaj.org/article/a2ec5519be3141949357ae26ecb70924
Autor:
Iris A Unterweger, Julie Klepstad, Edouard Hannezo, Pia R Lundegaard, Ala Trusina, Elke A Ober
Publikováno v:
PLoS Biology, Vol 21, Iss 10, p e3002315 (2023)
To meet the physiological demands of the body, organs need to establish a functional tissue architecture and adequate size as the embryo develops to adulthood. In the liver, uni- and bipotent progenitor differentiation into hepatocytes and biliary ep
Externí odkaz:
https://doaj.org/article/f3dfa61ca94e4f20962d72c9cdc2a81c
Autor:
Xiaochan Xu, Philip Allan Seymour, Kim Sneppen, Ala Trusina, Anuska la Rosa Egeskov-Madsen, Mette Christine Jørgensen, Mogens Høgh Jensen, Palle Serup
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Notch signaling is crucial for pancreatic cell fate choice. With mathematical modeling and experiments, Xu et al. provides new insights into how different Notch ligands and Hes1 oscillation guide the spatial-temporal dynamics of cell differentiation.
Externí odkaz:
https://doaj.org/article/a2eaa62cc36b47aea2401f79983fdc5d
Autor:
Marta Perera, Silas Boye Nissen, Martin Proks, Sara Pozzi, Rita S Monteiro, Ala Trusina, Joshua M Brickman
Publikováno v:
eLife, Vol 11 (2022)
During embryonic development cells acquire identity as they proliferate, implying that an intrinsic facet of cell fate choice requires coupling lineage decisions to cell division. How is the cell cycle regulated to promote or suppress heterogeneity a
Externí odkaz:
https://doaj.org/article/58c539994ff24b3fb5754170ffc2c21c
Publikováno v:
iScience, Vol 23, Iss 2, Pp - (2020)
Summary: How do flat sheets of cells form gut and neural tubes? Across systems, several mechanisms are at play: cells wedge, form actomyosin cables, or intercalate. As a result, the cell sheet bends, and the tube elongates. It is unclear to what exte
Externí odkaz:
https://doaj.org/article/05e2d938fe504ca8a9c443f8bf29d337
Autor:
Hjalte List Larsen, Laura Martín-Coll, Alexander Valentin Nielsen, Christopher V. E. Wright, Ala Trusina, Yung Hae Kim, Anne Grapin-Botton
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
The pancreas arises from a small population of cells but how individual cells contribute to organ formation is unclear. Here, the authors deconstruct pancreas organogenesis into clonal units, showing that single progenitors give rise to heterogeneous
Externí odkaz:
https://doaj.org/article/5617ac1576cd4daf93bca36ae542b223
Autor:
Natalia Sanchez de Groot, Marc Torrent Burgas, Charles NJ Ravarani, Ala Trusina, Salvador Ventura, M Madan Babu
Publikováno v:
Molecular Systems Biology, Vol 15, Iss 4, Pp n/a-n/a (2019)
Abstract Phase separation of soluble proteins into insoluble deposits is associated with numerous diseases. However, protein deposits can also function as membrane‐less compartments for many cellular processes. What are the fitness costs and benefi
Externí odkaz:
https://doaj.org/article/d4c0cd8793f240388d4a61302f5060a5
Publikováno v:
eLife, Vol 7 (2018)
Despite continual renewal and damages, a multicellular organism is able to maintain its complex morphology. How is this stability compatible with the complexity and diversity of living forms? Looking for answers at protein level may be limiting as di
Externí odkaz:
https://doaj.org/article/07bf902e9a154f4d88492bcb94781689
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Co-evolution of a new receptor-ligand pair will affect the downstream signal transduction network. Here, the authors use experimental evolution of yeast mating receptor Ste2 to show the effect of enhanced binding affinity and weakened interactions wi
Externí odkaz:
https://doaj.org/article/9ab4275031444dcfa4916e9056cc45fb
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Chromosomes contain large heterochromatin domains. Here, the authors measure the kinetics of heterochromatin formation in fission yeast and show both global and local feedbacks by nucleosome-bound enzymes are important for formation and stability of
Externí odkaz:
https://doaj.org/article/8880659a3dfa477c9b75c47c49059d14