Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Ala M. Shaqra"'
Autor:
Joanna Zikos, Gabriela M. Webb, Helen L. Wu, Jason S. Reed, Jennifer Watanabe, Jodie L. Usachenko, Ala M. Shaqra, Celia A. Schiffer, Koen K. A. Van Rompay, Jonah B. Sacha, Diogo M. Magnani
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
Prenatal administration of monoclonal antibodies (mAbs) is a strategy that could be exploited to prevent viral infections during pregnancy and early life. To reach protective levels in fetuses, mAbs must be transported across the placenta, a selectiv
Externí odkaz:
https://doaj.org/article/c3903556c3ab42faabeedc9cf418281c
Publikováno v:
Viruses, Vol 16, Iss 9, p 1419 (2024)
Enterovirus-D68 (EV68) has emerged as a global health concern over the last decade with severe symptomatic infections resulting in long-lasting neurological deficits and death. Unfortunately, there are currently no FDA-approved antiviral drugs for EV
Externí odkaz:
https://doaj.org/article/b304b3b4b5dd451dbbc5d39452e58a8a
Autor:
Ala M. Shaqra, Sarah N. Zvornicanin, Qiu Yu J. Huang, Gordon J. Lockbaum, Mark Knapp, Laura Tandeske, David T. Bakan, Julia Flynn, Daniel N. A. Bolon, Stephanie Moquin, Dustin Dovala, Nese Kurt Yilmaz, Celia A. Schiffer
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
The authors determined crystal structures of the main protease (Mpro) of SARS-CoV-2 bound to substrate peptides. These structures define the substrate envelope and enable identification of sites that may be susceptible to drug resistance.
Externí odkaz:
https://doaj.org/article/9bf0515b0c364d1eb5c19629a361ea7c
Autor:
Sarah N. Zvornicanin, Ala M. Shaqra, Qiuyu J. Huang, Elizabeth Ornelas, Mallika Moghe, Mark Knapp, Stephanie Moquin, Dustin Dovala, Celia A. Schiffer, Nese Kurt Yilmaz
Publikováno v:
Viruses, Vol 15, Iss 3, p 781 (2023)
With the spread of SARS-CoV-2 throughout the globe causing the COVID-19 pandemic, the threat of zoonotic transmissions of coronaviruses (CoV) has become even more evident. As human infections have been caused by alpha- and beta-CoVs, structural chara
Externí odkaz:
https://doaj.org/article/9ffbfdbf549b423f93c1b2a6fa8578c1
Autor:
Julia M. Flynn, Qiu Yu J. Huang, Sarah N. Zvornicanin, Gily Schneider-Nachum, Ala M. Shaqra, Nese Kurt Yilmaz, Stephanie A. Moquin, Dustin Dovala, Celia A. Schiffer, Daniel N.A. Bolon
Drugs that target the main protease (Mpro) of SARS-CoV-2 are effective therapeutics that have entered clinical use. Wide-scale use of these drugs will apply selection pressure for the evolution of resistance mutations. To understand resistance potent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7711be1bb8dfcd376640c160705a31c0
https://doi.org/10.1101/2023.03.02.530652
https://doi.org/10.1101/2023.03.02.530652
Autor:
Jacqueto Zephyr, Desaboini Nageswara Rao, Colby Johnson, Ala M. Shaqra, Ellen A. Nalivaika, Aria Jordan, Nese Kurt Yilmaz, Akbar Ali, Celia A. Schiffer
Publikováno v:
Bioorganic chemistry. 131
Viruses from the Flavivirus genus infect millions of people worldwide and cause severe diseases, including recent epidemics of dengue virus (DENV), and Zika virus (ZIKV). There is currently no antiviral treatment against flavivirus infections, despit
Autor:
Mark W. Peczuh, Santosh Keshipeddy, Chris Lorenc, Dennis L. Wright, Liza Henowitz, Victoria L. Robinson, Zachary P. Cannone, Ala M. Shaqra, Adam Zweifach
Publikováno v:
ACS Combinatorial Science. 21:192-197
Many small molecule natural products with antibiotic and antiproliferative activity are adorned with a carbohydrate residue as part of their molecular structure. The carbohydrate moiety can act to mediate key interactions with the target, attenuate p
Autor:
Victoria L. Robinson, Kevin J. Boyd, Eric R. May, Ala M. Shaqra, Gilman Dionne, Madhubrata Ghosh, Heidi Erlandsen, Ganesh S. Anand
Publikováno v:
Biophysical Journal. 120:217a
Autor:
Ala M. Shaqra
Publikováno v:
Biophysical Journal. 104(2)
BipA is a member of the translational family of GTPases and is required for bacterial survival under various adverse environmental conditions. It is the only protein that differentially binds to two ribosomal particles. Under normal growth conditions
Autor:
Alicia E. Every, Eric R. May, Ala M. Shaqra, Gilman Dionne, Ganesh S. Anand, Victoria L. Robinson, Balakrishnin S. Moorthy
Publikováno v:
Biophysical Journal. 104:258a-259a
BipA is a conserved prokaryotic GTPase necessary for securing bacterial survival and successful invasion of the host. Structural and biochemical studies indicate that GTP and ppGpp compete for binding to BipA and promote differential association of B