Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Ala′ A.A. Al-Subeihi"'
Autor:
Ivonne M.C.M. Rietjens, Reiko Kiwamoto, Peter J. van Bladeren, Ala′ A.A. Al-Subeihi, Wasma Alhusainy, Bert Spenkelink, Ans Punt
Publikováno v:
Toxicology and Applied Pharmacology, 283(2), 117-126
Toxicology and Applied Pharmacology 283 (2015) 2
Toxicology and Applied Pharmacology 283 (2015) 2
The present study aims at predicting the level of formation of the ultimate carcinogenic metabolite of methyleugenol, 1'-sulfooxymethyleugenol, in the human population by taking variability in key bioactivation and detoxification reactions into accou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::752fa88501904185053e1dd948ac8c8e
https://doi.org/10.1016/j.taap.2014.12.009
https://doi.org/10.1016/j.taap.2014.12.009
Autor:
Amer J. Al-Malahmeh, Ala′ A.A. Al-Subeihi, Abdelmajeed Al-Ajlouni, Reiko Kiwamoto, Jacques Vervoort, Sebastiaan Wesseling, Ivonne M.C.M. Rietjens, Ans E. M. F. Soffers
Publikováno v:
Archives of Toxicology, 91
Archives of Toxicology
Archives of Toxicology 91 (2017)
Archives of Toxicology
Archives of Toxicology 91 (2017)
The present study describes physiologically based kinetic (PBK) models for the alkenylbenzene myristicin that were developed by extension of the PBK models for the structurally related alkenylbenzene safrole in rat and human. The newly developed myri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5770643cbc6fd7419d73a8ca6be8538
https://research.wur.nl/en/publications/physiologically-based-kinetic-modeling-of-the-bioactivation-of-my
https://research.wur.nl/en/publications/physiologically-based-kinetic-modeling-of-the-bioactivation-of-my
Autor:
Reiko Kiwamoto, Amer J. Al_Malahmeh, Jacques Vervoort, Sebastiaan Wesseling, Ivonne M.C.M. Rietjens, Abdalmajeed M. Alajlouni, Ala′ A.A. Al-Subeihi, Ans E. M. F. Soffers
Publikováno v:
Food and Chemical Toxicology 89 (2016)
Food and Chemical Toxicology, 89, 138-150
Food and Chemical Toxicology, 89, 138-150
The present study developed physiologically-based kinetic (PBK) models for the alkenylbenzene apiol in order to facilitate risk assessment based on read-across from the related alkenylbenzene safrole. Model predictions indicate that in rat liver the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25dcb7e065021f8dcabbaa8c94e3d23a
https://research.wur.nl/en/publications/mode-of-action-based-risk-assessment-of-the-botanical-food-borne-
https://research.wur.nl/en/publications/mode-of-action-based-risk-assessment-of-the-botanical-food-borne-
Autor:
Ivonne M.C.M. Rietjens, Alicia Paini, Jacques Vervoort, Wasma Alhusainy, Ans Punt, Ala′ A.A. Al-Subeihi, Peter J. van Bladeren
Publikováno v:
Food and Chemical Toxicology, 59, 564-571
Food and Chemical Toxicology 59 (2013)
Food and Chemical Toxicology 59 (2013)
Methyleugenol (ME) occurs naturally in a variety of spices, herbs, including basil, and their essential oils. ME induces hepatomas in rodent bioassays following its conversion to a DNA reactive metabolite. In the present study, the basil constituent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff1c803f9900477fda34f240f42d1a02
https://pubmed.ncbi.nlm.nih.gov/23831728
https://pubmed.ncbi.nlm.nih.gov/23831728
Autor:
Ans Punt, Ivonne M.C.M. Rietjens, Bert Spenkelink, Peter J. van Bladeren, Ala′ A.A. Al-Subeihi, Marelle G. Boersma
Publikováno v:
Toxicology and Applied Pharmacology, 260(3), 271-284
Toxicology and Applied Pharmacology 260 (2012) 3
Toxicology and Applied Pharmacology 260 (2012) 3
This study defines a physiologically based kinetic (PBK) model for methyleugenol (ME) in human based on in vitro and in silico derived parameters. With the model obtained, bioactivation and detoxification of methyleugenol (ME) at different doses leve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05b0c83cce710da20c5c99a37570c133
https://pubmed.ncbi.nlm.nih.gov/22445790
https://pubmed.ncbi.nlm.nih.gov/22445790
Autor:
Novalia Rachmawati, Ans Punt, Marelle G. Boersma, Jacques Vervoort, Bert Spenkelink, Ala′ A.A. Al-Subeihi, Ivonne M.C.M. Rietjens, Peter J. van Bladeren
Publikováno v:
Toxicology in Vitro 25 (2011) 1
Toxicology in Vitro, 25(1), 267-285
Toxicology in Vitro, 25(1), 267-285
The present study defines a physiologically based biokinetic (PBBK) model for the alkenylbenzene methyleugenol in rat based on in vitro metabolic parameters determined using relevant tissue fractions, in silico derived partition coefficients, and phy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a75f82b732d7c351b8d149a02f451d94
https://pubmed.ncbi.nlm.nih.gov/20828604
https://pubmed.ncbi.nlm.nih.gov/20828604