Human exposure to diesel exhaust induces CYP1A1 expression and AhR activation without a coordinated antioxidant response

Autor: M. Friberg, A. F. Behndig, J. A. Bosson, Ala Muala, S. Barath, R. Dove, D. Glencross, F. J. Kelly, A. Blomberg, I. S. Mudway, T. Sandström, J. Pourazar

Publikováno v: Particle and Fibre Toxicology, Vol 20, Iss 1, Pp 1-13 (2023)

Abstract Background Diesel exhaust (DE) induces neutrophilia and lymphocytosis in experimentally exposed humans. These responses occur in parallel to nuclear migration of NF-κB and c-Jun, activation of mitogen activated protein kinases and increased

Externí odkaz: https://doaj.org/article/e9531d56fc7c476fb68512267664b83d

Comparable Response Following Exposure to Biodiesel and Diesel Exhaust Particles in Advanced Multicellular Human Lung Models

Autor: Mizanur Rahman, Swapna Upadhyay, Koustav Ganguly, Micol Introna, Jie Ji, Christoffer Boman, Ala Muala, Anders Blomberg, Thomas Sandström, Lena Palmberg

Publikováno v: Toxics, Vol 11, Iss 6, p 532 (2023)

Biodiesel is considered to be a sustainable alternative for fossil fuels such as petroleum-based diesel. However, we still lack knowledge about the impact of biodiesel emissions on humans, as airways and lungs are the primary target organs of inhaled

Externí odkaz: https://doaj.org/article/7ceb89c272d9484aae68c13390ca40b2

Human exposure to diesel exhaust induces CYP1A1 expression via AhR activation without a coordinated antioxidant response

Autor: Maria Friberg, Annelie Flodström Behndig, Jenny Ann Bosson, Ala Muala, Stefan Barath, Rosamund Dove, Drew Glencross, Frank James Kelly, Anders Blomberg, Ian Stanley Mudway, Thomas Sandström, Jamshid Pourazar

Background Diesel exhaust (DE) induces neutrophilia and lymphocytosis in experimentally exposed humans. These responses occur in parallel to nuclear migration of NF-κB and c-Jun, activation of mitogen activated protein kinases and increased producti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dea9d90efaa6d761f568ad71a83148d1
https://doi.org/10.21203/rs.3.rs-2507035/v1

TUBE project:Transport-derived ultrafines and the brain effects

Autor: Maria-Viola, Martikainen, Päivi, Aakko-Saksa, Lenie, van den Broek, Flemming R, Cassee, Roxana O, Carare, Sweelin, Chew, Andras, Dinnyes, Rosalba, Giugno, Katja M, Kanninen, Tarja, Malm, Ala, Muala, Maiken, Nedergaard, Anna, Oudin, Pedro, Oyola, Tobias V, Pfeiffer, Topi, Rönkkö, Sanna, Saarikoski, Thomas, Sandström, Roel P F, Schins, Jan, Topinka, Mo, Yang, Xiaowen, Zeng, Remco H S, Westerink, Pasi I, Jalava

Publikováno v: Martikainen, M V, Aakko-Saksa, P, Broek, L V D, Cassee, F R, Carare, R O, Chew, S, Dinnyes, A, Giugno, R, Kanninen, K M, Malm, T, Muala, A, Nedergaard, M, Oudin, A, Oyola, P, Pfeiffer, T V, Rönkkö, T, Saarikoski, S, Sandström, T, Schins, R P F, Topinka, J, Yang, M, Zeng, X, Westerink, R H S & Jalava, P I 2021, ' TUBE project : Transport-derived ultrafines and the brain effects ', International Journal of Environmental Research and Public Health, vol. 19, no. 1, 311 . https://doi.org/10.3390/ijerph19010311
International Journal of Environmental Research and Public Health, Vol 19, Iss 311, p 311 (2022)
Martikainen, M V, Aakko-Saksa, P, Broek, L V D, Cassee, F R, Carare, R O, Chew, S, Dinnyes, A, Giugno, R, Kanninen, K M, Malm, T, Muala, A, Nedergaard, M, Oudin, A, Oyola, P, Pfeiffer, T V, Rönkkö, T, Saarikoski, S, Sandström, T, Schins, R P F, Topinka, J, Yang, M, Zeng, X, Westerink, R H S & Jalava, P I 2022, ' TUBE project : Transport-derived ultrafines and the brain effects ', International Journal of Environmental Research and Public Health, vol. 19, no. 1, 311 . https://doi.org/10.3390/ijerph19010311
International Journal of Environmental Research and Public Health

The adverse effects of air pollutants on the respiratory and cardiovascular systems are unquestionable. However, in recent years, indications of effects beyond these organ systems have become more evident. Traffic-related air pollution has been linke

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::8a09ae2cb1c06c8ea5cc7e8eac30fee8
https://cris.vtt.fi/ws/files/54823130/ijerph19010311.pdf

Toxicological effects of particulate matter from a Nordic chimney wood stove on two human lung cell lines

Autor: Ala Muala, Natxo Garcia, Christoffer Boman, Thomas Sandström, Robert Lindgren, Oskari Uski, Greg Rankin, Anders Blomberg, Jamshid Pourazar

Publikováno v: Occupational and environmental health.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3edb5d4de917f131283157e2f4a6627a
https://doi.org/10.1183/13993003.congress-2019.pa1981