Scalable and cost-effective tosylation-mediated synthesis of antifungal and fungal diagnostic 6″-Modified amphiphilic kanamycins.

Autor: Subedi YP; Department of Chemistry and Biochemistry, Utah State University, 0300 Old Main Hill, Logan, UT, 84322-0300, USA., Pandey U; Department of Chemistry and Biochemistry, Utah State University, 0300 Old Main Hill, Logan, UT, 84322-0300, USA., Alfindee MN; Department of Chemistry and Biochemistry, Utah State University, 0300 Old Main Hill, Logan, UT, 84322-0300, USA., Montgomery H; Department of Chemistry and Biochemistry, Utah State University, 0300 Old Main Hill, Logan, UT, 84322-0300, USA., Roberts P; Department of Chemistry and Biochemistry, Utah State University, 0300 Old Main Hill, Logan, UT, 84322-0300, USA., Wight J; Department of Chemistry and Biochemistry, Utah State University, 0300 Old Main Hill, Logan, UT, 84322-0300, USA., Nichols G; Department of Chemistry and Biochemistry, Utah State University, 0300 Old Main Hill, Logan, UT, 84322-0300, USA., Grilley M; Department of Biology, Utah State University, 5305 Old Main Hill, Logan, UT, 84322-5305, USA., Takemoto JY; Department of Biology, Utah State University, 5305 Old Main Hill, Logan, UT, 84322-5305, USA., Chang CT; Department of Chemistry and Biochemistry, Utah State University, 0300 Old Main Hill, Logan, UT, 84322-0300, USA. Electronic address: tom.chang@usu.edu.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2019 Nov 15; Vol. 182, pp. 111639. Date of Electronic Publication: 2019 Aug 22.

Synthesis and biological activity investigation of azole and quinone hybridized phosphonates.

Autor: Subedi YP; Department of Chemistry and Biochemistry, Utah State University, 0300 Old Main Hill, Logan, UT 84322-0300, USA., Alfindee MN; Department of Chemistry and Biochemistry, Utah State University, 0300 Old Main Hill, Logan, UT 84322-0300, USA; Department of Pharmaceutical Chemistry, College of Pharmacy, University of Basra, Basra, Iraq., Shrestha JP; Department of Chemistry and Biochemistry, Utah State University, 0300 Old Main Hill, Logan, UT 84322-0300, USA., Becker G; Department of Chemistry and Biochemistry, Utah State University, 0300 Old Main Hill, Logan, UT 84322-0300, USA., Grilley M; Department of Biology, Utah State University, 5305 Old Main Hill, Logan, UT 84322-5305, USA., Takemoto JY; Department of Biology, Utah State University, 5305 Old Main Hill, Logan, UT 84322-5305, USA., Chang CT; Department of Chemistry and Biochemistry, Utah State University, 0300 Old Main Hill, Logan, UT 84322-0300, USA. Electronic address: tom.chang@usu.edu.

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2018 Oct 01; Vol. 28 (18), pp. 3034-3037. Date of Electronic Publication: 2018 Aug 02.

Inhibition of Connexin Hemichannels by New Amphiphilic Aminoglycosides without Antibiotic Activity.

Autor: AlFindee MN; Department of Chemistry and Biochemistry, Utah State University, 0300 Old Main Hill, Logan, Utah 84322-0300, United States.; Department of Pharmaceutical Chemistry, College of Pharmacy, University of Basra, Basra, Iraq., Subedi YP; Department of Chemistry and Biochemistry, Utah State University, 0300 Old Main Hill, Logan, Utah 84322-0300, United States., Fiori MC; Department of Cell Physiology and Molecular Biophysics, and Center for Membrane Protein Research, Texas Tech University Health Sciences Center, Lubbock, Texas 79430-6551, United States., Krishnan S; Department of Cell Physiology and Molecular Biophysics, and Center for Membrane Protein Research, Texas Tech University Health Sciences Center, Lubbock, Texas 79430-6551, United States., Kjellgren A; Department of Cell Physiology and Molecular Biophysics, and Center for Membrane Protein Research, Texas Tech University Health Sciences Center, Lubbock, Texas 79430-6551, United States.; Honors College, McClellan Hall, Box 41017, Texas Tech University, Lubbock, Texas 79409-1017, United States., Altenberg GA; Department of Cell Physiology and Molecular Biophysics, and Center for Membrane Protein Research, Texas Tech University Health Sciences Center, Lubbock, Texas 79430-6551, United States., Chang CT; Department of Chemistry and Biochemistry, Utah State University, 0300 Old Main Hill, Logan, Utah 84322-0300, United States.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2018 Jun 19; Vol. 9 (7), pp. 697-701. Date of Electronic Publication: 2018 Jun 19 (Print Publication: 2018).

One-step synthesis of carbohydrate esters as antibacterial and antifungal agents.

Autor: AlFindee MN; Department of Chemistry and Biochemistry, Utah State University, 0300 Old Main Hill, Logan, UT 84322-0300, USA; Department of Pharmaceutical Chemistry, College of Pharmacy, University of Basra, Basra, Iraq., Zhang Q; Department of Chemistry and Biochemistry, Utah State University, 0300 Old Main Hill, Logan, UT 84322-0300, USA., Subedi YP; Department of Chemistry and Biochemistry, Utah State University, 0300 Old Main Hill, Logan, UT 84322-0300, USA., Shrestha JP; Department of Chemistry and Biochemistry, Utah State University, 0300 Old Main Hill, Logan, UT 84322-0300, USA., Kawasaki Y; Department of Biology, Utah State University, 5305 Old Main Hill, Logan, UT 84322-5305, USA., Grilley M; Department of Biology, Utah State University, 5305 Old Main Hill, Logan, UT 84322-5305, USA., Takemoto JY; Department of Biology, Utah State University, 5305 Old Main Hill, Logan, UT 84322-5305, USA., Chang CT; Department of Chemistry and Biochemistry, Utah State University, 0300 Old Main Hill, Logan, UT 84322-0300, USA. Electronic address: tom.chang@usu.edu.

Publikováno v: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2018 Feb 01; Vol. 26 (3), pp. 765-774. Date of Electronic Publication: 2017 Dec 26.

Structure-activity relationships for antibacterial to antifungal conversion of kanamycin to amphiphilic analogues.

Autor: Fosso M; †Department of Chemistry and Biochemistry, Utah State University, 0300 Old Main Hill, Logan, Utah 84322-0300, United States., AlFindee MN; †Department of Chemistry and Biochemistry, Utah State University, 0300 Old Main Hill, Logan, Utah 84322-0300, United States., Zhang Q; †Department of Chemistry and Biochemistry, Utah State University, 0300 Old Main Hill, Logan, Utah 84322-0300, United States., Nziko Vde P; †Department of Chemistry and Biochemistry, Utah State University, 0300 Old Main Hill, Logan, Utah 84322-0300, United States., Kawasaki Y; ‡Department of Biology, Utah State University, 5305 Old Main Hill, Logan, Utah 84322-5305, United States., Shrestha SK; ‡Department of Biology, Utah State University, 5305 Old Main Hill, Logan, Utah 84322-5305, United States., Bearss J; †Department of Chemistry and Biochemistry, Utah State University, 0300 Old Main Hill, Logan, Utah 84322-0300, United States., Gregory R; †Department of Chemistry and Biochemistry, Utah State University, 0300 Old Main Hill, Logan, Utah 84322-0300, United States., Takemoto JY; ‡Department of Biology, Utah State University, 5305 Old Main Hill, Logan, Utah 84322-5305, United States., Chang CW; †Department of Chemistry and Biochemistry, Utah State University, 0300 Old Main Hill, Logan, Utah 84322-0300, United States.

Publikováno v: The Journal of organic chemistry [J Org Chem] 2015 May 01; Vol. 80 (9), pp. 4398-411. Date of Electronic Publication: 2015 Apr 13.