Synthesis of novel phthalazine-based derivatives with potent cytotoxicity against HCT-116 cells through apoptosis and VEGFR2 inhibition.

Autor: El Sayed D; Chemistry Department, Faculty of Science, Suez Canal University P.O. 41522 Ismailia Egypt mohamed_nafie@science.suez.edu.eg samir_elrayes@science.suez.edu.eg., El Rayes SM; Chemistry Department, Faculty of Science, Suez Canal University P.O. 41522 Ismailia Egypt mohamed_nafie@science.suez.edu.eg samir_elrayes@science.suez.edu.eg., Soliman HA; Chemistry Department, Faculty of Science, Suez Canal University P.O. 41522 Ismailia Egypt mohamed_nafie@science.suez.edu.eg samir_elrayes@science.suez.edu.eg., AlBalaa IE; Science Department, Faculty of Basic Educations, PAAET Kuwait Safat 22081 Kuwait., Alturki MS; Department of Pharmaceutical Chemistry, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University P.O. Box 1982 Dammam 31441 Eastern Province Kingdom of Saudi Arabia., Al Khzem AH; Department of Pharmaceutical Chemistry, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University P.O. Box 1982 Dammam 31441 Eastern Province Kingdom of Saudi Arabia., Alsharif MA; King Fahad Armed Forces Hospital Al Kurnaysh Rd, Al Andalus Jeddah 23311 Kingdom of Saudi Arabia., Nafie MS; Chemistry Department, Faculty of Science, Suez Canal University P.O. 41522 Ismailia Egypt mohamed_nafie@science.suez.edu.eg samir_elrayes@science.suez.edu.eg.; Department of Chemistry, College of Sciences, University of Sharjah P.O. 27272 Sharjah United Arab Emirates mohamed.elsayed@sharjah.ac.ae.

Publikováno v: RSC advances [RSC Adv] 2024 Apr 24; Vol. 14 (19), pp. 13027-13043. Date of Electronic Publication: 2024 Apr 24 (Print Publication: 2024).