Zobrazeno 1 - 10
of 754
pro vyhledávání: '"Al-awar R"'
Autor:
Hu D; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, M5G 0A3, Canada.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, M5S 1A8, Canada., Thériault BL; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, M5G 0A3, Canada.; Currently at Fusion Pharmaceuticals Inc, Hamilton, ON, L8P 0A6, Canada., Talebian V; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, M5G 0A3, Canada., Hoffer L; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, M5G 0A3, Canada., Owen J; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, M5G 0A3, Canada., Lim J; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, M5S 3E1, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 1A8, Canada., Blencowe BJ; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, M5S 3E1, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 1A8, Canada., Lima-Fernandes E; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, M5G 0A3, Canada., Saraon P; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, M5G 0A3, Canada.; RA Capital Management, L.P, Boston, MA, 02116, USA., Marcellus R; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, M5G 0A3, Canada., Al-Awar R; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, M5G 0A3, Canada. ralawar@oicr.on.ca.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, M5S 1A8, Canada. ralawar@oicr.on.ca.; Department of Chemistry, University of Toronto, Toronto, ON, M5S 1A8, Canada. ralawar@oicr.on.ca.
Publikováno v:
Scientific reports [Sci Rep] 2025 Jan 02; Vol. 15 (1), pp. 315. Date of Electronic Publication: 2025 Jan 02.
Autor:
Mabanglo MF; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, Canada., Wilson B; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, Canada., Noureldin M; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, Canada., Kimani SW; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada., Mamai A; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, Canada., Krausser C; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, Canada., González-Álvarez H; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, Canada.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada., Srivastava S; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, Canada., Mohammed M; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, Canada., Hoffer L; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, Canada., Chan M; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, Canada., Avrumutsoae J; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, Canada., Li ASM; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, Canada.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada., Hajian T; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, Canada., Tucker S; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, Canada., Green S; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada., Szewczyk M; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada., Barsyte-Lovejoy D; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada., Santhakumar V; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada., Ackloo S; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada., Loppnau P; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada., Li Y; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada., Seitova A; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada., Kiyota T; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, Canada., Wang JG; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, Canada., Privé GG; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Kuntz DA; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Patel B; Piramal Discovery Solutions, Pharmaceutical Special Economic Zone, Ahmedabad, Gujarat, India., Rathod V; Piramal Discovery Solutions, Pharmaceutical Special Economic Zone, Ahmedabad, Gujarat, India., Vala A; Piramal Discovery Solutions, Pharmaceutical Special Economic Zone, Ahmedabad, Gujarat, India., Rout B; Piramal Discovery Solutions, Pharmaceutical Special Economic Zone, Ahmedabad, Gujarat, India., Aman A; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, Canada.; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada., Poda G; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, Canada.; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada., Uehling D; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, Canada., Ramnauth J; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, Canada., Halabelian L; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada., Marcellus R; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, Canada., Al-Awar R; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, Canada. ralawar@oicr.on.ca.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada. ralawar@oicr.on.ca.; Department of Chemistry, University of Toronto, Toronto, ON, Canada. ralawar@oicr.on.ca., Vedadi M; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, Canada. mvedadi@oicr.on.ca.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada. mvedadi@oicr.on.ca.
Publikováno v:
Nature communications [Nat Commun] 2024 Nov 23; Vol. 15 (1), pp. 10165. Date of Electronic Publication: 2024 Nov 23.
Autor:
Němec V; Institute for Pharmaceutical Chemistry, Structural Genomics Consortium, Johann Wolfgang Goethe-University, Max-von-Laue-Strasse 9, Frankfurt am Main, 60438, Germany.; Department of Chemistry, Masaryk University, Brno 625 00, Czech Republic., Remeš M; Department of Chemistry, Masaryk University, Brno 625 00, Czech Republic., Beňovský P; Department of Chemistry, Masaryk University, Brno 625 00, Czech Republic., Böck MC; Department of Chemistry, Masaryk University, Brno 625 00, Czech Republic., Šranková E; Department of Chemistry, Masaryk University, Brno 625 00, Czech Republic., Wong JF; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, U.K., Cros J; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, U.K., Williams E; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, U.K., Tse LH; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, U.K., Smil D; Drug Discovery Program, Ontario Institute for Cancer Research, 661 University Avenue, Toronto, Ontario M5G 0A3, Canada., Ensan D; Drug Discovery Program, Ontario Institute for Cancer Research, 661 University Avenue, Toronto, Ontario M5G 0A3, Canada., Isaac MB; Drug Discovery Program, Ontario Institute for Cancer Research, 661 University Avenue, Toronto, Ontario M5G 0A3, Canada., Al-Awar R; Drug Discovery Program, Ontario Institute for Cancer Research, 661 University Avenue, Toronto, Ontario M5G 0A3, Canada.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario M5S 1A8, Canada., Gomolková R; Department of Biology, Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic.; Institute of Animal Physiology and Genetics of the Czech Academy of Sciences, 602 00 Brno, Czech Republic., Ursachi VC; Department of Biology, Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic.; International Clinical Research Center, St. Anne's University Hospital, 602 00 Brno, Czech Republic., Fafílek B; Department of Biology, Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic.; Institute of Animal Physiology and Genetics of the Czech Academy of Sciences, 602 00 Brno, Czech Republic.; International Clinical Research Center, St. Anne's University Hospital, 602 00 Brno, Czech Republic., Kahounová Z; Institute of Biophysics of the Czech Academy of Sciences, Královopolská 135, 612 00 Brno Czech Republic., Víchová R; Institute of Biophysics of the Czech Academy of Sciences, Královopolská 135, 612 00 Brno Czech Republic., Vacek O; International Clinical Research Center, St. Anne's University Hospital, 602 00 Brno, Czech Republic.; Institute of Biophysics of the Czech Academy of Sciences, Královopolská 135, 612 00 Brno Czech Republic., Berger BT; Institute for Pharmaceutical Chemistry, Structural Genomics Consortium, Johann Wolfgang Goethe-University, Max-von-Laue-Strasse 9, Frankfurt am Main, 60438, Germany., Wells CI; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States., Corona CR; Promega Corporation, Madison, Wisconsin 53716, United States., Vasta JD; Promega Corporation, Madison, Wisconsin 53716, United States., Robers MB; Promega Corporation, Madison, Wisconsin 53716, United States., Krejci P; Department of Biology, Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic.; Institute of Animal Physiology and Genetics of the Czech Academy of Sciences, 602 00 Brno, Czech Republic.; International Clinical Research Center, St. Anne's University Hospital, 602 00 Brno, Czech Republic., Souček K; International Clinical Research Center, St. Anne's University Hospital, 602 00 Brno, Czech Republic.; Institute of Biophysics of the Czech Academy of Sciences, Královopolská 135, 612 00 Brno Czech Republic., Bullock AN; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, U.K., Knapp S; Institute for Pharmaceutical Chemistry, Structural Genomics Consortium, Johann Wolfgang Goethe-University, Max-von-Laue-Strasse 9, Frankfurt am Main, 60438, Germany., Paruch K; Department of Chemistry, Masaryk University, Brno 625 00, Czech Republic.; Institute of Animal Physiology and Genetics of the Czech Academy of Sciences, 602 00 Brno, Czech Republic.
Publikováno v:
Journal of medicinal chemistry [J Med Chem] 2024 Aug 08; Vol. 67 (15), pp. 12632-12659. Date of Electronic Publication: 2024 Jul 18.
Autor:
Best AJ; Donnelly Centre, University of Toronto, Toronto, ON, Canada. andy.best@utoronto.ca., Braunschweig U; Donnelly Centre, University of Toronto, Toronto, ON, Canada., Wu M; Donnelly Centre, University of Toronto, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Farhangmehr S; Donnelly Centre, University of Toronto, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Pasculescu A; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada., Lim JJ; Donnelly Centre, University of Toronto, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Comsa LC; Donnelly Centre, University of Toronto, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Jen M; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada., Wang J; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada., Datti A; Department of Agricultural, Food, and Environmental Sciences, University of Perugia, Perugia, Italy., Wrana JL; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada., Cordes SP; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada., Al-Awar R; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada., Han H; Donnelly Centre, University of Toronto, Toronto, ON, Canada., Blencowe BJ; Donnelly Centre, University of Toronto, Toronto, ON, Canada. b.blencowe@utoronto.ca.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada. b.blencowe@utoronto.ca.
Publikováno v:
Nature communications [Nat Commun] 2024 Jul 27; Vol. 15 (1), pp. 6328. Date of Electronic Publication: 2024 Jul 27.
Autor:
Su Y; Department of Oncology, Wayne State University School of Medicine, Detroit, Michigan.; Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan.; National Engineering Laboratory for AIDS Vaccine, Key Laboratory for Molecular Enzymology and Engineering, the Ministry of Education, School of Life Sciences, Jilin University, Changchun, P. R. China., Carter JL; Cancer Biology Graduate Program, Wayne State University School of Medicine, Detroit, Michigan.; MD/PhD Program, Wayne State University School of Medicine, Detroit, Michigan., Li X; National Engineering Laboratory for AIDS Vaccine, Key Laboratory for Molecular Enzymology and Engineering, the Ministry of Education, School of Life Sciences, Jilin University, Changchun, P. R. China., Fukuda Y; Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee., Gray A; Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee.; Integrated Biomedical Sciences Program, University of Tennessee Health Science Center, Memphis, Tennessee., Lynch J; Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee., Edwards H; Department of Oncology, Wayne State University School of Medicine, Detroit, Michigan.; Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan., Ma J; National Engineering Laboratory for AIDS Vaccine, Key Laboratory for Molecular Enzymology and Engineering, the Ministry of Education, School of Life Sciences, Jilin University, Changchun, P. R. China., Schreiner P; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee., Polin L; Department of Oncology, Wayne State University School of Medicine, Detroit, Michigan.; Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan., Kushner J; Department of Oncology, Wayne State University School of Medicine, Detroit, Michigan.; Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan., Dzinic SH; Department of Oncology, Wayne State University School of Medicine, Detroit, Michigan.; Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan., Buck SA; Division of Pediatric Hematology/Oncology, Children's Hospital of Michigan, Detroit, Michigan., Pruett-Miller SM; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.; Center for Advanced Genome Engineering, St. Jude Children's Research Hospital, Memphis, Tennessee., Hege-Hurrish K; Cancer Biology Graduate Program, Wayne State University School of Medicine, Detroit, Michigan., Robinson C; St. Jude Children's Research Hospital Shared Imaging Resource, Memphis, Tennessee., Qiao X; National Engineering Laboratory for AIDS Vaccine, Key Laboratory for Molecular Enzymology and Engineering, the Ministry of Education, School of Life Sciences, Jilin University, Changchun, P. R. China., Liu S; National Engineering Laboratory for AIDS Vaccine, Key Laboratory for Molecular Enzymology and Engineering, the Ministry of Education, School of Life Sciences, Jilin University, Changchun, P. R. China., Wu S; National Engineering Laboratory for AIDS Vaccine, Key Laboratory for Molecular Enzymology and Engineering, the Ministry of Education, School of Life Sciences, Jilin University, Changchun, P. R. China., Wang G; National Engineering Laboratory for AIDS Vaccine, Key Laboratory for Molecular Enzymology and Engineering, the Ministry of Education, School of Life Sciences, Jilin University, Changchun, P. R. China., Li J; Department of Oncology, Wayne State University School of Medicine, Detroit, Michigan.; Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan., Allen JE; Chimerix, Inc., Durham, North Carolina., Prabhu VV; Chimerix, Inc., Durham, North Carolina., Schimmer AD; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada., Joshi D; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada., Kalhor-Monfared S; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada., Watson IDG; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada., Marcellus R; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada., Isaac MB; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada., Al-Awar R; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada., Taub JW; Division of Pediatric Hematology/Oncology, Children's Hospital of Michigan, Detroit, Michigan.; Department of Pediatrics, Wayne State University School of Medicine, Detroit, Michigan., Lin H; Department of Hematology and Oncology, The First Hospital of Jilin University, Changchun, P.R. China., Schuetz JD; Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee., Ge Y; Department of Oncology, Wayne State University School of Medicine, Detroit, Michigan.; Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan.; MD/PhD Program, Wayne State University School of Medicine, Detroit, Michigan.
Publikováno v:
Cancer research [Cancer Res] 2024 Apr 01; Vol. 84 (7), pp. 1084-1100.
Autor:
González-Álvarez H; Drug Discovery Program, Ontario Institute for Cancer Research, 661 University Avenue, MaRS Centre, West Tower, Toronto, Ontario M5G 0A3, Canada.; Department of Pharmacology and Toxicology, University of Toronto, Medical Sciences Building, Room 4207, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada., Ensan D; Drug Discovery Program, Ontario Institute for Cancer Research, 661 University Avenue, MaRS Centre, West Tower, Toronto, Ontario M5G 0A3, Canada.; Department of Pharmacology and Toxicology, University of Toronto, Medical Sciences Building, Room 4207, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada., Xin T; Drug Discovery Program, Ontario Institute for Cancer Research, 661 University Avenue, MaRS Centre, West Tower, Toronto, Ontario M5G 0A3, Canada., Wong JF; Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford OX3 7DQ, U.K., Zepeda-Velázquez CA; Drug Discovery Program, Ontario Institute for Cancer Research, 661 University Avenue, MaRS Centre, West Tower, Toronto, Ontario M5G 0A3, Canada., Cros J; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7FZ, U.K., Sweeney MN; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7FZ, U.K., Hoffer L; Drug Discovery Program, Ontario Institute for Cancer Research, 661 University Avenue, MaRS Centre, West Tower, Toronto, Ontario M5G 0A3, Canada., Kiyota T; Drug Discovery Program, Ontario Institute for Cancer Research, 661 University Avenue, MaRS Centre, West Tower, Toronto, Ontario M5G 0A3, Canada., Wilson BJ; Drug Discovery Program, Ontario Institute for Cancer Research, 661 University Avenue, MaRS Centre, West Tower, Toronto, Ontario M5G 0A3, Canada., Aman A; Drug Discovery Program, Ontario Institute for Cancer Research, 661 University Avenue, MaRS Centre, West Tower, Toronto, Ontario M5G 0A3, Canada.; Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College Street, Toronto, Ontario M5S 3M2, Canada., Roberts O; M4K Pharma, 101 College Street, MaRS Centre, South Tower, Toronto, Ontario M5G 1L7, Canada., Isaac MB; Drug Discovery Program, Ontario Institute for Cancer Research, 661 University Avenue, MaRS Centre, West Tower, Toronto, Ontario M5G 0A3, Canada., Bullock AN; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7FZ, U.K., Smil D; Drug Discovery Program, Ontario Institute for Cancer Research, 661 University Avenue, MaRS Centre, West Tower, Toronto, Ontario M5G 0A3, Canada., Al-Awar R; Drug Discovery Program, Ontario Institute for Cancer Research, 661 University Avenue, MaRS Centre, West Tower, Toronto, Ontario M5G 0A3, Canada.; Department of Pharmacology and Toxicology, University of Toronto, Medical Sciences Building, Room 4207, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada.; Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario M5S 3H6, Canada.
Publikováno v:
Journal of medicinal chemistry [J Med Chem] 2024 Mar 28; Vol. 67 (6), pp. 4707-4725. Date of Electronic Publication: 2024 Mar 18.
Autor:
Ganguly A; Centre for Translational Pharmacology, School of Molecular Biosciences, Advanced Research Centre (ARC), College of Medical, Veterinary and Life Sciences University of Glasgow, Glasgow, UK., Quon T; Centre for Translational Pharmacology, School of Molecular Biosciences, Advanced Research Centre (ARC), College of Medical, Veterinary and Life Sciences University of Glasgow, Glasgow, UK., Jenkins L; Centre for Translational Pharmacology, School of Molecular Biosciences, Advanced Research Centre (ARC), College of Medical, Veterinary and Life Sciences University of Glasgow, Glasgow, UK., Joseph B; Drug Discovery Program, Ontario Institute for Cancer Research, MaRS Centre, Toronto, Ontario, Canada., Al-Awar R; Drug Discovery Program, Ontario Institute for Cancer Research, MaRS Centre, Toronto, Ontario, Canada., Chevigne A; Division of Immuno-Pharmacology and Interactomics, Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg., Tobin AB; Centre for Translational Pharmacology, School of Molecular Biosciences, Advanced Research Centre (ARC), College of Medical, Veterinary and Life Sciences University of Glasgow, Glasgow, UK., Uehling DE; Drug Discovery Program, Ontario Institute for Cancer Research, MaRS Centre, Toronto, Ontario, Canada., Hoffmann C; Institute for Molecular Cell Biology, CMB-Center for Molecular Biomedicine, University Hospital Jena, Friedrich Schiller University Jena, Jena, Germany., Drube J; Institute for Molecular Cell Biology, CMB-Center for Molecular Biomedicine, University Hospital Jena, Friedrich Schiller University Jena, Jena, Germany., Milligan G; Centre for Translational Pharmacology, School of Molecular Biosciences, Advanced Research Centre (ARC), College of Medical, Veterinary and Life Sciences University of Glasgow, Glasgow, UK. Electronic address: Graeme.Milligan@glasgow.ac.uk.
Publikováno v:
The Journal of biological chemistry [J Biol Chem] 2023 Oct; Vol. 299 (10), pp. 105218. Date of Electronic Publication: 2023 Sep 01.
Autor:
Bahlmann LC; Institute of Biomedical Engineering, 164 College Street, Toronto, Ontario, M5S 3G9, Canada; The Donnelly Centre, University of Toronto, Toronto, 160 College St, Ontario, M5S 3E1, Canada., Xue C; Institute of Biomedical Engineering, 164 College Street, Toronto, Ontario, M5S 3G9, Canada; The Donnelly Centre, University of Toronto, Toronto, 160 College St, Ontario, M5S 3E1, Canada., Chin AA; The Donnelly Centre, University of Toronto, Toronto, 160 College St, Ontario, M5S 3E1, Canada; Department of Chemical Engineering and Applied Chemistry, University of Toronto, 200 College Street, Toronto, Ontario, M5S 3E5, Canada., Skirzynska A; Institute of Biomedical Engineering, 164 College Street, Toronto, Ontario, M5S 3G9, Canada; The Donnelly Centre, University of Toronto, Toronto, 160 College St, Ontario, M5S 3E1, Canada; Department of Chemical Engineering and Applied Chemistry, University of Toronto, 200 College Street, Toronto, Ontario, M5S 3E5, Canada., Lu J; Institute of Biomedical Engineering, 164 College Street, Toronto, Ontario, M5S 3G9, Canada; The Donnelly Centre, University of Toronto, Toronto, 160 College St, Ontario, M5S 3E1, Canada., Thériault B; Drug Discovery Program, Ontario Institute of Cancer Research, 661 University Ave Suite 510, Toronto, Ontario, M5G 0A3, Canada., Uehling D; Drug Discovery Program, Ontario Institute of Cancer Research, 661 University Ave Suite 510, Toronto, Ontario, M5G 0A3, Canada., Yerofeyeva Y; Biomarker Imaging Research Laboratory, Sunnybrook Research Institute, 2075 Bayview Ave, Toronto, Ontario, M4N 3M5, Canada., Peters R; Biomarker Imaging Research Laboratory, Sunnybrook Research Institute, 2075 Bayview Ave, Toronto, Ontario, M4N 3M5, Canada., Liu K; Biomarker Imaging Research Laboratory, Sunnybrook Research Institute, 2075 Bayview Ave, Toronto, Ontario, M4N 3M5, Canada., Chen J; Department of Medical Biophysics, University of Toronto, 101 College St Suite 15-701, Toronto, Ontario, M5G 1L7, Canada., Martel AL; Department of Medical Biophysics, University of Toronto, 101 College St Suite 15-701, Toronto, Ontario, M5G 1L7, Canada; Physical Sciences, Odette Cancer Research Program, Sunnybrook Research Institute, 2075 Bayview Ave, Toronto, Ontario, M4N 3M5, Canada., Yaffe M; Department of Medical Biophysics, University of Toronto, 101 College St Suite 15-701, Toronto, Ontario, M5G 1L7, Canada; Physical Sciences, Odette Cancer Research Program, Sunnybrook Research Institute, 2075 Bayview Ave, Toronto, Ontario, M4N 3M5, Canada., Al-Awar R; Drug Discovery Program, Ontario Institute of Cancer Research, 661 University Ave Suite 510, Toronto, Ontario, M5G 0A3, Canada; Department of Pharmacology & Toxicology, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada., Goswami RS; Biological Sciences, Odette Cancer Research Program, Sunnybrook Research Institute, 2075 Bayview Ave, Toronto, Ontario, M4N 3M5, Canada; Department of Laboratory Medicine and Molecular Diagnostics, Sunnybrook Health Sciences Centre, 2075 Bayview Ave, Toronto, Ontario, M4N 3M5, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, 1 King's College Circle, Toronto, Ontario, M5S 1A8, Canada., Ylanko J; Biological Sciences, Odette Cancer Research Program, Sunnybrook Research Institute, 2075 Bayview Ave, Toronto, Ontario, M4N 3M5, Canada., Andrews DW; Department of Medical Biophysics, University of Toronto, 101 College St Suite 15-701, Toronto, Ontario, M5G 1L7, Canada; Biological Sciences, Odette Cancer Research Program, Sunnybrook Research Institute, 2075 Bayview Ave, Toronto, Ontario, M4N 3M5, Canada; Department of Biochemistry, University of Toronto, 1 King's College Circle, Toronto, Ontario, M5S 1A8, Canada., Kuruvilla J; Princess Margaret Cancer Centre, University Health Network, 610 University Ave, Toronto, Ontario, M5G 2C1, Canada., Laister RC; Princess Margaret Cancer Centre, University Health Network, 610 University Ave, Toronto, Ontario, M5G 2C1, Canada. Electronic address: Rob.Laister@uhnresearch.ca., Shoichet MS; Institute of Biomedical Engineering, 164 College Street, Toronto, Ontario, M5S 3G9, Canada; The Donnelly Centre, University of Toronto, Toronto, 160 College St, Ontario, M5S 3E1, Canada; Department of Chemical Engineering and Applied Chemistry, University of Toronto, 200 College Street, Toronto, Ontario, M5S 3E5, Canada; Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario, M5S 3H6, Canada. Electronic address: molly.shoichet@utoronto.ca.
Publikováno v:
Biomaterials [Biomaterials] 2023 Jun; Vol. 297, pp. 122121. Date of Electronic Publication: 2023 Apr 09.
Autor:
Li ASM; Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada.; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, Ontario M5G 0A3, Canada.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario M5S 1A8, Canada., Kimani S; Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada.; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 2C1, Canada., Wilson B; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, Ontario M5G 0A3, Canada., Noureldin M; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, Ontario M5G 0A3, Canada.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario M5S 1A8, Canada., González-Álvarez H; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, Ontario M5G 0A3, Canada.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario M5S 1A8, Canada., Mamai A; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, Ontario M5G 0A3, Canada., Hoffer L; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, Ontario M5G 0A3, Canada., Guilinger JP; X-Chem Inc., Waltham, Massachusetts 02453, United States., Zhang Y; X-Chem Inc., Waltham, Massachusetts 02453, United States., von Rechenberg M; Relay Therapeutics, Cambridge, Massachusetts 02139, United States., Disch JS; Relay Therapeutics, Cambridge, Massachusetts 02139, United States., Mulhern CJ; Relay Therapeutics, Cambridge, Massachusetts 02139, United States., Slakman BL; Relay Therapeutics, Cambridge, Massachusetts 02139, United States., Cuozzo JW; Relay Therapeutics, Cambridge, Massachusetts 02139, United States., Dong A; Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada., Poda G; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, Ontario M5G 0A3, Canada.; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario M5S 3M2, Canada., Mohammed M; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, Ontario M5G 0A3, Canada., Saraon P; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, Ontario M5G 0A3, Canada., Mittal M; Piramal Discovery Solutions, Pharmaceutical Special Economic Zone, Ahmedabad, Gujarat 382213, India., Modh P; Piramal Discovery Solutions, Pharmaceutical Special Economic Zone, Ahmedabad, Gujarat 382213, India., Rathod V; Piramal Discovery Solutions, Pharmaceutical Special Economic Zone, Ahmedabad, Gujarat 382213, India., Patel B; Piramal Discovery Solutions, Pharmaceutical Special Economic Zone, Ahmedabad, Gujarat 382213, India., Ackloo S; Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada., Santhakumar V; Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada., Szewczyk MM; Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada., Barsyte-Lovejoy D; Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario M5S 1A8, Canada., Arrowsmith CH; Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada.; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 2C1, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 1L7, Canada., Marcellus R; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, Ontario M5G 0A3, Canada., Guié MA; X-Chem Inc., Waltham, Massachusetts 02453, United States., Keefe AD; X-Chem Inc., Waltham, Massachusetts 02453, United States., Brown PJ; Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada., Halabelian L; Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario M5S 1A8, Canada., Al-Awar R; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, Ontario M5G 0A3, Canada.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.; Department of Chemistry, University of Toronto, Toronto, Ontario M5S 3H6, Canada., Vedadi M; Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada.; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, Ontario M5G 0A3, Canada.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
Publikováno v:
Journal of medicinal chemistry [J Med Chem] 2023 Apr 13; Vol. 66 (7), pp. 5041-5060. Date of Electronic Publication: 2023 Mar 22.
Autor:
Mamai A; Drug Discovery Program, Ontario Institute for Cancer Research, 661 University Avenue, Suite 510, Toronto, OntarioM5G 0A3, Canada., Chau AM; Drug Discovery Program, Ontario Institute for Cancer Research, 661 University Avenue, Suite 510, Toronto, OntarioM5G 0A3, Canada., Wilson BJ; Drug Discovery Program, Ontario Institute for Cancer Research, 661 University Avenue, Suite 510, Toronto, OntarioM5G 0A3, Canada., Watson ID; Drug Discovery Program, Ontario Institute for Cancer Research, 661 University Avenue, Suite 510, Toronto, OntarioM5G 0A3, Canada., Joseph BB; Drug Discovery Program, Ontario Institute for Cancer Research, 661 University Avenue, Suite 510, Toronto, OntarioM5G 0A3, Canada., Subramanian PR; Drug Discovery Program, Ontario Institute for Cancer Research, 661 University Avenue, Suite 510, Toronto, OntarioM5G 0A3, Canada., Morshed MM; Drug Discovery Program, Ontario Institute for Cancer Research, 661 University Avenue, Suite 510, Toronto, OntarioM5G 0A3, Canada., Morin JA; Drug Discovery Program, Ontario Institute for Cancer Research, 661 University Avenue, Suite 510, Toronto, OntarioM5G 0A3, Canada., Prakesch MA; Drug Discovery Program, Ontario Institute for Cancer Research, 661 University Avenue, Suite 510, Toronto, OntarioM5G 0A3, Canada., Lu T; Janssen Research & Development, LLC, 1400 McKean Road, Spring House, Pennsylvania19477, United States., Connolly P; Janssen Research & Development, LLC, 1400 McKean Road, Spring House, Pennsylvania19477, United States., Kuntz DA; Princess Margaret Cancer Centre, Toronto, OntarioM5G 2C1, Canada., Pomroy NC; Princess Margaret Cancer Centre, Toronto, OntarioM5G 2C1, Canada., Poda G; Drug Discovery Program, Ontario Institute for Cancer Research, 661 University Avenue, Suite 510, Toronto, OntarioM5G 0A3, Canada.; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, OntarioM5S 3M2, Canada., Nguyen K; Drug Discovery Program, Ontario Institute for Cancer Research, 661 University Avenue, Suite 510, Toronto, OntarioM5G 0A3, Canada., Marcellus R; Drug Discovery Program, Ontario Institute for Cancer Research, 661 University Avenue, Suite 510, Toronto, OntarioM5G 0A3, Canada., Strathdee G; Drug Discovery Program, Ontario Institute for Cancer Research, 661 University Avenue, Suite 510, Toronto, OntarioM5G 0A3, Canada., Theriault B; Drug Discovery Program, Ontario Institute for Cancer Research, 661 University Avenue, Suite 510, Toronto, OntarioM5G 0A3, Canada., Subramaniam R; Drug Discovery Program, Ontario Institute for Cancer Research, 661 University Avenue, Suite 510, Toronto, OntarioM5G 0A3, Canada., Mohammed M; Drug Discovery Program, Ontario Institute for Cancer Research, 661 University Avenue, Suite 510, Toronto, OntarioM5G 0A3, Canada., Abibi A; Drug Discovery Program, Ontario Institute for Cancer Research, 661 University Avenue, Suite 510, Toronto, OntarioM5G 0A3, Canada., Chan M; Drug Discovery Program, Ontario Institute for Cancer Research, 661 University Avenue, Suite 510, Toronto, OntarioM5G 0A3, Canada., Winston J; Drug Discovery Program, Ontario Institute for Cancer Research, 661 University Avenue, Suite 510, Toronto, OntarioM5G 0A3, Canada., Kiyota T; Drug Discovery Program, Ontario Institute for Cancer Research, 661 University Avenue, Suite 510, Toronto, OntarioM5G 0A3, Canada., Undzys E; Drug Discovery Program, Ontario Institute for Cancer Research, 661 University Avenue, Suite 510, Toronto, OntarioM5G 0A3, Canada., Aman A; Drug Discovery Program, Ontario Institute for Cancer Research, 661 University Avenue, Suite 510, Toronto, OntarioM5G 0A3, Canada.; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, OntarioM5S 3M2, Canada., Austin N; Janssen Research & Development, LLC, 1400 McKean Road, Spring House, Pennsylvania19477, United States., Du Jardin M; Janssen Research & Development, LLC, 1400 McKean Road, Spring House, Pennsylvania19477, United States., Packman K; Janssen Research & Development, LLC, 1400 McKean Road, Spring House, Pennsylvania19477, United States., Phillippar U; Janssen Research & Development, Turnhoutseweg 30, B-2340Beerse, Belgium., Attar R; Janssen Research & Development, LLC, 1400 McKean Road, Spring House, Pennsylvania19477, United States., Edwards J; Janssen Research & Development, LLC, 1400 McKean Road, Spring House, Pennsylvania19477, United States., O'Meara J; Drug Discovery Program, Ontario Institute for Cancer Research, 661 University Avenue, Suite 510, Toronto, OntarioM5G 0A3, Canada., Uehling DE; Drug Discovery Program, Ontario Institute for Cancer Research, 661 University Avenue, Suite 510, Toronto, OntarioM5G 0A3, Canada., Al-Awar R; Drug Discovery Program, Ontario Institute for Cancer Research, 661 University Avenue, Suite 510, Toronto, OntarioM5G 0A3, Canada.; Department of Chemistry, University of Toronto, Toronto, OntarioM5S 3H6, Canada.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, OntarioM5S 1A8, Canada., Privé GG; Princess Margaret Cancer Centre, Toronto, OntarioM5G 2C1, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, OntarioM5G 1L7, Canada.; Department of Biochemistry, University of Toronto, Toronto, OntarioM5S 1A8, Canada., Isaac MB; Drug Discovery Program, Ontario Institute for Cancer Research, 661 University Avenue, Suite 510, Toronto, OntarioM5G 0A3, Canada.
Publikováno v:
ACS medicinal chemistry letters [ACS Med Chem Lett] 2023 Jan 12; Vol. 14 (2), pp. 199-210. Date of Electronic Publication: 2023 Jan 12 (Print Publication: 2023).