Pumice as a Novel Nature Heterogeneous Catalyst for Synthesis of 3,4-dihydropyrimidine-2-(1H)-Ones/Thiones via Biginelli Reaction under Solvent-free Conditions

Autor: Saber S, Abou El-Hamd H. Mohamed, Abdelhamid A, Kanzi N, Al-Wahaibi Lh

An efficient and environmentally Pumice as a new catalyst for designing of 3,4- dihydropyrimidin-2(1H) ones / thiones via one-pot multi component condensation of aromatic aldehydes, urea/ thiourea and ethyl acetoacetate or acetyl acetone in excellent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f621f29bc1bbd7cf9901735f70b5fd85
https://doi.org/10.20944/preprints202105.0493.v1

Synthesis, enzyme inhibition, and docking studies of new schiff bases of disalicylic acid methylene-based derivatives as dual-target antibacterial agents.

Autor: Al-Wahaibi LH; Department of Chemistry, College of Sciences, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia., Mahmoud MA; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut, Egypt., Alzahrani HA; Applied Medical Science College, Medical Laboratory Technology Department, Northern Border University, Arar, Saudi Arabia., Abou-Zied HA; Medicinal Chemistry Department, Faculty of Pharmacy, Deraya University, Minia, Egypt., Abdelmoez A; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut, Egypt., Youssif BGM; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut, Egypt., Bräse S; Institute of Biological and Chemical Systems - Functional Molecular Systems (IBCS-FMS), Karlsruhe Institute of Technology, Karlsruhe, Germany., Rabea SM; Medicinal Chemistry Department, Faculty of Pharmacy, Minia University, Minia, Egypt.; Apogee Pharmaceuticals, Burnaby, BC, Canada.

Publikováno v: Frontiers in chemistry [Front Chem] 2024 Nov 12; Vol. 12, pp. 1493906. Date of Electronic Publication: 2024 Nov 12 (Print Publication: 2024).

RETRACTED: Al-Wahaibi et al. Optimized Conjugation of Fluvastatin to HIV-1 TAT Displays Enhanced Pro-Apoptotic Activity in HepG2 Cells. Int. J. Mol. Sci. 2020, 21 , 4138.

Autor: Al-Wahaibi LH; Department of Chemistry, Science College, Princess Nourah Bint Abdulrahman University, Riyadh 11671, Saudi Arabia., Al-Saleem MSM; Department of Chemistry, Science College, Princess Nourah Bint Abdulrahman University, Riyadh 11671, Saudi Arabia., Ahmed OAA; Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia., Fahmy UA; Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia., Alhakamy NA; Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia., Eid BG; Department of Pharmacology and Toxicology, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia., Abdel-Naim AB; Department of Pharmacology and Toxicology, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia., Abdel-Mageed WM; Department of Pharmacognosy, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia., AlRasheed MM; Department of Clinical Pharmacy, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia., Shazly GA; Department of Pharmaceutics, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2024 Nov 08; Vol. 25 (22). Date of Electronic Publication: 2024 Nov 08.

New Pyrazole/Pyrimidine-Based Scaffolds as Inhibitors of Heat Shock Protein 90 Endowed with Apoptotic Anti-Breast Cancer Activity.

Autor: Al-Wahaibi LH; Department of Chemistry, College of Sciences, Princess Nourah bint Abdulrahman University, Riyadh 11671, Saudi Arabia., Elbastawesy MAI; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, Egypt., Abodya NE; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Tabuk, Tabuk 71491, Saudi Arabia., Youssif BGM; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt., Bräse S; Institute of Biological and Chemical Systems, IBCS-FMS, Karlsruhe Institute of Technology, 76131 Karlsruhe, Germany., Shabaan SN; Department of Chemistry, Faculty of Science (Girls), Al-Azhar University, Nasr City, Cairo 11754, Egypt., Sayed GH; Heterocyclic Synthesis Lab., Chemistry Department, Faculty of Science, Ain Shams University, Abbassia, Cairo 11566, Egypt., Anwer KE; Heterocyclic Synthesis Lab., Chemistry Department, Faculty of Science, Ain Shams University, Abbassia, Cairo 11566, Egypt.

Publikováno v: Pharmaceuticals (Basel, Switzerland) [Pharmaceuticals (Basel)] 2024 Sep 27; Vol. 17 (10). Date of Electronic Publication: 2024 Sep 27.

Design and Synthesis of New Dihydropyrimidine Derivatives with a Cytotoxic Effect as Dual EGFR/VEGFR-2 Inhibitors.

Autor: Al-Wahaibi LH; Department of Chemistry, College of Sciences, Princess Nourah Bint Abdulrahman University, Riyadh 11671, Saudi Arabia., Elshamsy AM; Pharmceutical Chemistry Department, Faculty of Pharmacy, Deraya University, Minia 61517, Egypt., Ali TFS; Medicinal Chemistry Department, Faculty of Pharmacy, Minia University, Minia 61519, Egypt., Youssif BGM; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt., Bräse S; Institute of Biological and Chemical Systems, IBCS-FMS, Karlsruhe Institute of Technology, 76131 Karlsruhe, Germany., Abdel-Aziz M; Medicinal Chemistry Department, Faculty of Pharmacy, Minia University, Minia 61519, Egypt., El-Koussi NA; Pharmceutical Chemistry Department, Faculty of Pharmacy, Deraya University, Minia 61517, Egypt.; Department of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt.

Publikováno v: ACS omega [ACS Omega] 2024 Aug 01; Vol. 9 (32), pp. 34358-34369. Date of Electronic Publication: 2024 Aug 01 (Print Publication: 2024).