Zobrazeno 1 - 10
of 631
pro vyhledávání: '"Al-Huniti A"'
Publikováno v:
Pharmacia, Vol 71, Iss , Pp 1-7 (2024)
Vestibular migraine (VM) has conventionally been treated through acute migraine-aborting therapeutic interventions and prevention to reduce migraines’ occurrence, length and intensity. There is growing attention to the development of non-pharmaceut
Externí odkaz:
https://doaj.org/article/4d62619cefcf43aa9dcbc7fd2f0b73d9
Autor:
Verhofste, Silvia, Al-Huniti, Ahmad, Novak, Marci, Conrad, Amy L., van der Plas, Ellen, Harshman, Lyndsay, Staber, Janice M.
Publikováno v:
In Blood Vessels, Thrombosis & Hemostasis December 2024 1(4)
Autor:
Jenny‐Hoa Nguyen, Daniel Epling, Nancy Dolphin, Anne Paccaly, Daniela Conrado, John D. Davis, Nidal Al‐Huniti
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 11, Pp 1458-1471 (2022)
Abstract A population pharmacokinetic (PopPK) model was previously developed for cemiplimab in patients with solid tumors, including advanced cutaneous squamous cell carcinoma (CSCC). Here, we update the existing PopPK model and characterize exposure
Externí odkaz:
https://doaj.org/article/d66296e49f744b368611427da7a3de74
Autor:
Masood Khaksar Toroghi, Nidal Al‐Huniti, John D. Davis, A. Thomas DiCioccio, Ronda Rippley, Alina Baum, Christos A. Kyratsous, Sumathi Sivapalasingam, Joel Kantrowitz, Mohamed A. Kamal
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 10, Pp 2538-2550 (2022)
Abstract REGN‐EB3 (Inmazeb) is a cocktail of three human monoclonal antibodies approved for treatment of Ebola infection. This paper describes development of a mathematical model linking REGN‐EB3’s inhibition of Ebola virus to survival in a non
Externí odkaz:
https://doaj.org/article/83b15c1160f94b0d8109850eff0e84a2
Akademický článek
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Autor:
Brilleman, Samuel L., Crowther, Michael J., Moreno-Betancur, Margarita, Novik, Jacqueline Buros, Dunyak, James, Al-Huniti, Nidal, Fox, Robert, Hammerbacher, Jeff, Wolfe, Rory
Joint modelling of longitudinal and time-to-event data has received much attention recently. Increasingly, extensions to standard joint modelling approaches are being proposed to handle complex data structures commonly encountered in applied research
Externí odkaz:
http://arxiv.org/abs/1805.06099
Akademický článek
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Autor:
Masood Khaksar Toroghi, Jim Bosley, Lyn M. Powell, Yi Zhang, Feng Yang, Xia Pu, John D. Davis, Nidal Al‐Huniti
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 11, Pp 1332-1342 (2021)
Abstract A model to quantitatively characterize the effect of evinacumab, an investigational monoclonal antibody against angiopoietin‐like protein 3 (ANGPTL3) on lipid trafficking is needed. A quantitative systems pharmacology (QSP) approach was de
Externí odkaz:
https://doaj.org/article/f2c85718b9bd447bb1c865f81dfe8b6c
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 11, Pp 1412-1421 (2021)
Abstract Evinacumab, an angiopoietin‐like protein 3 (ANGPTL3) inhibitor, has been shown to significantly reduce low‐density lipoprotein cholesterol (LDL‐C) in patients with homozygous familial hypercholesterolemia (HoFH). This work characterize
Externí odkaz:
https://doaj.org/article/7d13c590a1c64df5a16b0dbf274cfafe
Autor:
Nidal Al‐Huniti, Yan Feng, Jingyu (Jerry) Yu, Zheng Lu, Mario Nagase, Diansong Zhou, Jennifer Sheng
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 9, Iss 8, Pp 419-427 (2020)
Model‐informed drug development (MIDD) approaches have rapidly advanced in drug development in recent years. Additionally, the Prescription Drug User Fee Act (PDUFA) VI has specific commitments to further enhance MIDD. Tumor growth dynamic (TGD) mo
Externí odkaz:
https://doaj.org/article/f5a0e30482554d58b47438af183a2cb6