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Surfaceome interrogation using an RNA-seq approach highlights leukemia initiating cell biomarkers in an LMO2 T cell transgenic model

Autor: Pais, H, Ruggero, K, Zhang, J, Al-Assar, O, Bery, N, Bhuller, R, Weston, V, Kearns, P, Mecucci, C, Miller, A, Rabbitts, T

Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona
Scientific Reports, Vol 9, Iss 1, Pp 1-16 (2019)
Scientific Reports

The surfaceome is critical because surface proteins provide a gateway for internal signals and transfer of molecules into cells, and surfaceome differences can influence therapy response. We have used a surfaceome analysis method, based on comparing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::905881d86ad8be5c49427459b34378f2
http://hdl.handle.net/11391/1449431

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LMO2 and IL2RG synergize in thymocytes to mimic the evolution of SCID-X1 gene therapy-associated T-cell leukaemia

Autor: Ruggero, K, Al-Assar, O, Chambers, J, Codrington, R, Brend, T, Rabbitts, T

Publikováno v: Leukemia

The SCID-X1 disease occurs in males that lack a functional X-linked gene encoding the interleukin 2 receptor subunit gamma (IL2RG) and thus are immuno-deficient (reviewed in Rochman et al.). Gene therapy has been a success in curing SCID-X1 in patien

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::3565ab3f2d072cdcbd5d232a6e7a915f
http://europepmc.org/articles/PMC5227057

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The plasma biomarker soluble SIGLEC-1 is associated with the type I interferon transcriptional signature, ethnic background and renal disease in systemic lupus erythematosus

Autor: Oliveira, JJ, Karrar, S, Rainbow, DB, Pinder, CL, Clarke, P, García, A, Al-Assar, O, Burling, K, Morris, S, Stratton, R, Vyse, TJ, Wicker, LS, Todd, JA, Ferreira, R

Publikováno v: Arthritis Research & Therapy, Vol 20, Iss 1, Pp 1-13 (2018)

Background The molecular heterogeneity of autoimmune and inflammatory diseases has been one of the main obstacles to the development of safe and specific therapeutic options. Here, we evaluated the diagnostic and clinical value of a robust, inexpensi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::bfc5d3f3c497b31828aa7e759ccbba31
https://www.repository.cam.ac.uk/handle/1810/278528

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A non-cell autonomous mouse model of CNS haemangioblastoma mediated by mutant KRAS

Autor: Bao, L, Al-Assar, O, Drynan, LF, Arends, MJ, Tyers, P, Barker, RA, Rabbitts, TH

Publikováno v: Scientific Reports
Bao, L, Al-Assa, O, Drynan, L F, Arends, M, Tyers, P, Barker, R A & Rabbitts, T H 2017, ' A non-cell autonomous mouse model of CNS haemangioblastoma mediated by mutant KRAS ', Scientific Reports, vol. 7, pp. 44899 . https://doi.org/10.1038/srep44899

Haemangioblastoma is a rare malignancy of the CNS where vascular proliferation causes lesions due to endothelial propagation. We found that conditionally expressing mutant Kras, using Rag1-Cre, gave rise to CNS haemangioblastoma in the cortex and cer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b5e4089fb89392ff1110d5622d5ffee
http://europepmc.org/articles/PMC5359595

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