Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Al Y. Lin"'
Autor:
David C. Gervasi, Christian H. Kjaergaard, Mitchell C. Brenner, Ingrid Langsetmo, Volkmar Guenzler, Pierre E. Signore, Steve J. Klaus, Guangjie Guo, Ughetta del Balzo, Todd W. Seeley, Gail Walkinshaw, F. Aisha Chow, Thomas B. Neff, Al Y. Lin, David Y. Liu, Lee A. Flippin, Qingjian Wang, Michael P. Arend
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 374:342-353
Anemia of chronic kidney disease (CKD) is a multifactorial disorder caused by impaired erythropoietin (EPO) production and altered iron homeostasis associated with inflammation. Hypoxia-inducible factor (HIF) is a transcription factor that stimulates
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 8, p e0255022 (2021)
PLoS ONE, Vol 16, Iss 8 (2021)
PLoS ONE, Vol 16, Iss 8, p e0255022 (2021)
PLoS ONE, Vol 16, Iss 8 (2021)
Prolyl hydroxylase (PH) enzymes control the degradation of hypoxia-inducible factor (HIF), a transcription factor known to regulate erythropoiesis, angiogenesis, glucose metabolism, cell proliferation, and apoptosis. HIF-PH inhibitors (HIF-PHIs) corr
Publikováno v:
International Journal of Toxicology. 36:427-439
The carcinogenic potential of roxadustat (FG-4592), a novel orally active, heterocyclic small molecule inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PH) enzymes in clinical development for treatment of anemia, was evaluated in CD-1 mi
Autor:
Mark E. Metzger, Aisha Wynter, Al Y. Lin, Robert E. Donahue, John F. Tisdale, Carol Wong, Reginald Smith, Ingrid Langsetmo, Stephen J. Klaus, Griffin P. Rodgers, N. Seth Linde, Matthew M. Hsieh
The hypoxia-inducible factor (HIF) pathway is crucial in mitigating the deleterious effects of oxygen deprivation. HIF-α is an essential component of the oxygen-sensing mechanisms and under normoxic conditions is targeted for degradation via hydroxy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61da66bd7313a3ffe6d9837eb28ada3a
https://europepmc.org/articles/PMC1976368/
https://europepmc.org/articles/PMC1976368/
Autor:
William R. Usinger, Guangjie Guo, Julia Gray, Todd W. Seeley, Noelynn A. Oliver, Mitch Brenner, Weihua Zhang, Qingjian Wang, Leon Xu, Blake Nichols, Al Y. Lin, David A. Yeowell
Publikováno v:
Fibrogenesis & Tissue Repair
Background Connective tissue growth factor (CTGF) is widely thought to promote the development of fibrosis in collaboration with transforming growth factor (TGF)-β; however, most of the evidence for its involvement comes from correlative and culture
Autor:
P. Fourney, S. Oksanen, A. Fong, C. Molineaux, Al Y. Lin, S. Leigh, P. Urquilla, M. Brenner, E. Muthukrishnan, E. Turtle, D. Yeowell, L. Flippin
Publikováno v:
Blood. 104:174-174
High-altitude hypoxia stimulates erythropoiesis in anemic hemodialysis patients. Similarly, intermittent exposure to hypobaric hypoxia elevates EPO and stimulates erythropoiesis in normal subjects. HIF is a transcription factor that mediates the body