Bromodomain protein 4 discriminates tissue-specific super-enhancers containing disease-specific susceptibility loci in prostate and breast cancer

Autor: Zuber, V., Bettella, F., Witoelar, A.W., Andreassen, O.A., Mills, I.G., Urbanucci, A., Eeles, R.A., Easton, D.F., Kote-Jarai, Z., Al Olama, A.A., Benlloch, S., Muir, K., Giles, G.G., Wiklund, F., Grönberg, H., Haiman, C.A., Schleutker, J., Weischer, M., Travis, R.C., Neal, D., Pharoah, P., Khaw, K.T., Stanford, J.L., Blot, W.J., Thibodeau, S.N., Maier, C., Kibel, A.S., Cybulski, C., Cannon-Albright, L., Brenner, H., Park, J., Kaneva, R., Batra, J., Teixeira, M.R., Pandha, H., Chenevix-Trench, G., Humphreys, M.K., Hung, R.J., Han, Y., Brennan, P., Bickeböller, H., Rosenberger, A., Houlston, R.S., Caporaso, N., Landi, M.T., Heinrich, J., Risch, A., Wu, X., Ye, Y., Christiani, D.C., Amos, C.I., Michailidou, K., Bolla, M.K., Wang, Q., Berchuck, A., Antoniou, A.C., McGuffog, L., Couch, F.J., Offit, K., Dennis, J., Dunning, A.M., Lee, A., Dicks, E., Luccarini, C., Benítez, J., González-Neira, A., Simard, J., Tessier, D.C., Bacot, F., Vincent, D., Laboissiere, S.

Publikováno v: Zuber, V, Bettella, F, Witoelar, A, Andreassen, O A, Mills, I G, Urbanucci, A & PRACTICAL Consortium 2017, ' Bromodomain protein 4 discriminates tissue-specific super-enhancers containing disease-specific susceptibility loci in prostate and breast cancer ', BMC Genomics, vol. 18, no. 1, pp. 270 . https://doi.org/10.1186/s12864-017-3620-y
BMC Genomics 18:270 (2017)
BMC Genomics

Background Epigenetic information can be used to identify clinically relevant genomic variants single nucleotide polymorphisms (SNPs) of functional importance in cancer development. Super-enhancers are cell-specific DNA elements, acting to determine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::133f15c80a2e8e02e0caa94528d115e8
https://doi.org/10.1186/s12864-017-3620-y

Risk Analysis of Prostate Cancer in PRACTICAL, a Multinational Consortium, Using 25 Known Prostate Cancer Susceptibility Loci

Autor: Al Olama, A.A., Benlloch, S., Antoniou, A.C., Giles, G.G., Severi, G., Neal, D.E., Hamdy, F.C., Donovan, J.L., Muir, K., Schleutker, J., Henderson, B.E., Haiman, C.A., Schumacher, F.R., Pashayan, N., Pharoah, P.D.P., Ostrander, E.A., Stanford, J.L., Batra, J., Clements, J.A., Chambers, S.K., Weischer, M., Nordestgaard, B.G., Ingles, S.A., Sorensen, K.D., Orntoft, T.F., Park, J.Y., Cybulski, C., Maier, C., Doerk, T., Dickinson, J.L., Cannon-Albright, L., Brenner, H., Rebbeck, T.R., Zeigler-Johnson, C., Habuchi, T., Thibodeau, S.N., Cooney, K.A., Chappuis, P.O., Hutter, P., Kaneva, R.P., Foulkes, W.D., Zeegers, M.P., Lu, Y-J., Zhang, H-W., Stephenson, R., Cox, A., Southey, M.C., Spurdle, A.B., FitzGerald, L., Leongamornlert, D., Saunders, E., Tymrakiewicz, M., Guy, M., Dadaev, T., Little, S.J., Govindasami, K., Sawyer, E., Wilkinson, R., Herkommer, K., Hopper, J.L., Lophatonanon, A., Rinckleb, A.E., Kote-Jarai, Z., Eeles, R.A., Easton, D.F., Surgeons, B.A.U., Collaborators, U.K.P.S., Consortium, PRACTICAL.

BACKGROUND: Genome-wide association studies have identified multiple genetic variants associated with prostate cancer risk which explain a substantial proportion of familial relative risk. These variants can be used to stratify individuals by their r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::c3de628c0004c4250ff69598758cf63e
https://eprints.whiterose.ac.uk/110801/1/nihms676863.pdf

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