Long-term FXa inhibition attenuates thromboinflammation after acute myocardial infarction and stroke by platelet proteome alteration

Autor: Polzin, Amin, Benkhoff, Marcel, Thienel, Manuela, Barcik, Maike, Mourikis, Philipp, Shchurovska, Khrystyna, Helten, Carolin, Ehreiser, Vincent, Zhe, Zhang, von Wulffen, Franziska, Theiss, Alexander, Peri, Sameera, Cremer, Sophie, Ahlbrecht, Samantha, Zako, Saif, Wildeis, Laura, Al-Kassis, Gabrielle, Metzen, Daniel, Utz, Amelie, Hu, Hao, Vornholz, Lilian, Pavic, Goran, Lüsebrink, Enzo, Strecker, Jan, Tiedt, Steffen, Cramer, Mareike, Gliem, Michael, Ruck, Tobias, Meuth, Sven G., Zeus, Tobias, Mayr, Christoph, Schiller, Herbert B., Simon, Lukas, Massberg, Steffen, Kelm, Malte, Petzold, Tobias

Publikováno v: In Journal of Thrombosis and Haemostasis October 2024

Targeting Sphingosine-1-Phosphate Signaling to Prevent the Progression of Aortic Valve Disease.

Autor: Benkhoff M; Department of Cardiology, Pulmonology, and Vascular Medicine (M. Benkhoff, M. Barcik, P.M., J.D., P.K., M.H., T.H., S.Z., J.S., M.C., C.H., L.W., H.H., G.A.-K., D.M., J.W., L.D., C.Q., N.G., T.Z., M.K., A.P.), Heinrich Heine University Düsseldorf, Germany.; Institute of Analytical Chemistry, University of Vienna, Austria (M. Benkhoff, C.C., R.A., B.L.).; Department of Cardiac Surgery, University Hospital Aachen, RWTH Aachen University, Germany (M.B., P.A.)., Barcik M; Department of Cardiology, Pulmonology, and Vascular Medicine (M. Benkhoff, M. Barcik, P.M., J.D., P.K., M.H., T.H., S.Z., J.S., M.C., C.H., L.W., H.H., G.A.-K., D.M., J.W., L.D., C.Q., N.G., T.Z., M.K., A.P.), Heinrich Heine University Düsseldorf, Germany., Mourikis P; Department of Cardiology, Pulmonology, and Vascular Medicine (M. Benkhoff, M. Barcik, P.M., J.D., P.K., M.H., T.H., S.Z., J.S., M.C., C.H., L.W., H.H., G.A.-K., D.M., J.W., L.D., C.Q., N.G., T.Z., M.K., A.P.), Heinrich Heine University Düsseldorf, Germany., Dahlmanns J; Department of Cardiology, Pulmonology, and Vascular Medicine (M. Benkhoff, M. Barcik, P.M., J.D., P.K., M.H., T.H., S.Z., J.S., M.C., C.H., L.W., H.H., G.A.-K., D.M., J.W., L.D., C.Q., N.G., T.Z., M.K., A.P.), Heinrich Heine University Düsseldorf, Germany., Kahmann P; Department of Cardiology, Pulmonology, and Vascular Medicine (M. Benkhoff, M. Barcik, P.M., J.D., P.K., M.H., T.H., S.Z., J.S., M.C., C.H., L.W., H.H., G.A.-K., D.M., J.W., L.D., C.Q., N.G., T.Z., M.K., A.P.), Heinrich Heine University Düsseldorf, Germany., Wollnitzke P; Medical Faculty, Institute of Molecular Medicine III (P.W., J. Hoppe, N.S., J.D.-J.), Heinrich Heine University Düsseldorf, Germany., Hering M; Department of Cardiology, Pulmonology, and Vascular Medicine (M. Benkhoff, M. Barcik, P.M., J.D., P.K., M.H., T.H., S.Z., J.S., M.C., C.H., L.W., H.H., G.A.-K., D.M., J.W., L.D., C.Q., N.G., T.Z., M.K., A.P.), Heinrich Heine University Düsseldorf, Germany., Huckenbeck T; Department of Cardiology, Pulmonology, and Vascular Medicine (M. Benkhoff, M. Barcik, P.M., J.D., P.K., M.H., T.H., S.Z., J.S., M.C., C.H., L.W., H.H., G.A.-K., D.M., J.W., L.D., C.Q., N.G., T.Z., M.K., A.P.), Heinrich Heine University Düsseldorf, Germany., Hoppe J; Medical Faculty, Institute of Molecular Medicine III (P.W., J. Hoppe, N.S., J.D.-J.), Heinrich Heine University Düsseldorf, Germany., Semleit N; Medical Faculty, Institute of Molecular Medicine III (P.W., J. Hoppe, N.S., J.D.-J.), Heinrich Heine University Düsseldorf, Germany., Deister-Jonas J; Medical Faculty, Institute of Molecular Medicine III (P.W., J. Hoppe, N.S., J.D.-J.), Heinrich Heine University Düsseldorf, Germany., Zako S; Department of Cardiology, Pulmonology, and Vascular Medicine (M. Benkhoff, M. Barcik, P.M., J.D., P.K., M.H., T.H., S.Z., J.S., M.C., C.H., L.W., H.H., G.A.-K., D.M., J.W., L.D., C.Q., N.G., T.Z., M.K., A.P.), Heinrich Heine University Düsseldorf, Germany., Seel J; Department of Cardiology, Pulmonology, and Vascular Medicine (M. Benkhoff, M. Barcik, P.M., J.D., P.K., M.H., T.H., S.Z., J.S., M.C., C.H., L.W., H.H., G.A.-K., D.M., J.W., L.D., C.Q., N.G., T.Z., M.K., A.P.), Heinrich Heine University Düsseldorf, Germany., Coman C; Institute of Analytical Chemistry, University of Vienna, Austria (M. Benkhoff, C.C., R.A., B.L.)., Barth M, Cramer M; Department of Cardiology, Pulmonology, and Vascular Medicine (M. Benkhoff, M. Barcik, P.M., J.D., P.K., M.H., T.H., S.Z., J.S., M.C., C.H., L.W., H.H., G.A.-K., D.M., J.W., L.D., C.Q., N.G., T.Z., M.K., A.P.), Heinrich Heine University Düsseldorf, Germany., Helten C; Department of Cardiology, Pulmonology, and Vascular Medicine (M. Benkhoff, M. Barcik, P.M., J.D., P.K., M.H., T.H., S.Z., J.S., M.C., C.H., L.W., H.H., G.A.-K., D.M., J.W., L.D., C.Q., N.G., T.Z., M.K., A.P.), Heinrich Heine University Düsseldorf, Germany., Wildeis L; Department of Cardiology, Pulmonology, and Vascular Medicine (M. Benkhoff, M. Barcik, P.M., J.D., P.K., M.H., T.H., S.Z., J.S., M.C., C.H., L.W., H.H., G.A.-K., D.M., J.W., L.D., C.Q., N.G., T.Z., M.K., A.P.), Heinrich Heine University Düsseldorf, Germany., Hu H; Department of Cardiology, Pulmonology, and Vascular Medicine (M. Benkhoff, M. Barcik, P.M., J.D., P.K., M.H., T.H., S.Z., J.S., M.C., C.H., L.W., H.H., G.A.-K., D.M., J.W., L.D., C.Q., N.G., T.Z., M.K., A.P.), Heinrich Heine University Düsseldorf, Germany., Al-Kassis G; Department of Cardiology, Pulmonology, and Vascular Medicine (M. Benkhoff, M. Barcik, P.M., J.D., P.K., M.H., T.H., S.Z., J.S., M.C., C.H., L.W., H.H., G.A.-K., D.M., J.W., L.D., C.Q., N.G., T.Z., M.K., A.P.), Heinrich Heine University Düsseldorf, Germany., Metzen D; Department of Cardiology, Pulmonology, and Vascular Medicine (M. Benkhoff, M. Barcik, P.M., J.D., P.K., M.H., T.H., S.Z., J.S., M.C., C.H., L.W., H.H., G.A.-K., D.M., J.W., L.D., C.Q., N.G., T.Z., M.K., A.P.), Heinrich Heine University Düsseldorf, Germany., Hesse J; University Hospital Düsseldorf, Department of Molecular Cardiology (J. Hesse), Heinrich Heine University Düsseldorf, Germany., Weber J; Department of Cardiology, Pulmonology, and Vascular Medicine (M. Benkhoff, M. Barcik, P.M., J.D., P.K., M.H., T.H., S.Z., J.S., M.C., C.H., L.W., H.H., G.A.-K., D.M., J.W., L.D., C.Q., N.G., T.Z., M.K., A.P.), Heinrich Heine University Düsseldorf, Germany., Dannenberg L; Department of Cardiology, Pulmonology, and Vascular Medicine (M. Benkhoff, M. Barcik, P.M., J.D., P.K., M.H., T.H., S.Z., J.S., M.C., C.H., L.W., H.H., G.A.-K., D.M., J.W., L.D., C.Q., N.G., T.Z., M.K., A.P.), Heinrich Heine University Düsseldorf, Germany., Akhyari P; Department of Cardiac Surgery, University Hospital Aachen, RWTH Aachen University, Germany (M.B., P.A.)., Lichtenberg A; Department of Cardiac Surgery (A.L.), Heinrich Heine University Düsseldorf, Germany., Quast C; Department of Cardiology, Pulmonology, and Vascular Medicine (M. Benkhoff, M. Barcik, P.M., J.D., P.K., M.H., T.H., S.Z., J.S., M.C., C.H., L.W., H.H., G.A.-K., D.M., J.W., L.D., C.Q., N.G., T.Z., M.K., A.P.), Heinrich Heine University Düsseldorf, Germany., Gerdes N; Department of Cardiology, Pulmonology, and Vascular Medicine (M. Benkhoff, M. Barcik, P.M., J.D., P.K., M.H., T.H., S.Z., J.S., M.C., C.H., L.W., H.H., G.A.-K., D.M., J.W., L.D., C.Q., N.G., T.Z., M.K., A.P.), Heinrich Heine University Düsseldorf, Germany.; Cardiovascular Research Institute Düsseldorf, Germany (N.G., M.K., A.P.)., Zeus T; Department of Cardiology, Pulmonology, and Vascular Medicine (M. Benkhoff, M. Barcik, P.M., J.D., P.K., M.H., T.H., S.Z., J.S., M.C., C.H., L.W., H.H., G.A.-K., D.M., J.W., L.D., C.Q., N.G., T.Z., M.K., A.P.), Heinrich Heine University Düsseldorf, Germany., Borst O; Deutsche Forschungsgemeinschaft Heisenberg Group Cardiovascular Thromboinflammation and Translational Thrombocardiology (O.B.), University of Tübingen, Germany.; Department of Cardiology and Angiology (O.B.), University of Tübingen, Germany., Kelm M; Department of Cardiology, Pulmonology, and Vascular Medicine (M. Benkhoff, M. Barcik, P.M., J.D., P.K., M.H., T.H., S.Z., J.S., M.C., C.H., L.W., H.H., G.A.-K., D.M., J.W., L.D., C.Q., N.G., T.Z., M.K., A.P.), Heinrich Heine University Düsseldorf, Germany.; Cardiovascular Research Institute Düsseldorf, Germany (N.G., M.K., A.P.)., Petzold T; Department of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charité, Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, Germany (T.P.).; DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Germany (T.P.)., Ahrends R; Institute of Analytical Chemistry, University of Vienna, Austria (M. Benkhoff, C.C., R.A., B.L.)., Levkau B; Institute of Analytical Chemistry, University of Vienna, Austria (M. Benkhoff, C.C., R.A., B.L.)., Polzin A; Department of Cardiology, Pulmonology, and Vascular Medicine (M. Benkhoff, M. Barcik, P.M., J.D., P.K., M.H., T.H., S.Z., J.S., M.C., C.H., L.W., H.H., G.A.-K., D.M., J.W., L.D., C.Q., N.G., T.Z., M.K., A.P.), Heinrich Heine University Düsseldorf, Germany.; Cardiovascular Research Institute Düsseldorf, Germany (N.G., M.K., A.P.).; National Heart and Lung Institute, Imperial College London, United Kingdom (A.P.).

Publikováno v: Circulation [Circulation] 2024 Oct 21. Date of Electronic Publication: 2024 Oct 21.