Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Al E. Stewart"'
Autor:
Alexei Brooun, Ketan S. Gajiwala, Ya-Li Deng, Wei Liu, Ben Bolaños, Patrick Bingham, You-Ai He, Wade Diehl, Nicole Grable, Pei-Pei Kung, Scott Sutton, Karen A. Maegley, Xiu Yu, Al E. Stewart
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Polycomb repressive complex 2 (PRC2) mediates gene silencing through chromatin reorganization by methylation of histone H3 lysine 27 (H3K27). Here, the authors present crystal structures of the inhibitor-bound wild-type and a mutant form of PRC2.
Externí odkaz:
https://doaj.org/article/845df6d19e6c440e8657bbebe46e34a8
Autor:
Nandini Chaturbhai Patel, Dafydd R. Owen, Rhonda D. Cardin, Karen J. Coffman, Jean G. Sathish, Devendra K. Rai, Heather Eng, Charlotte Moira Norfor Allerton, Jack C. Lee, Britton Boras, Melissa Avery, Qingyi Yang, Eugene P. Kadar, Anthony Carlo, Annaliesa S. Anderson, Matthew R. Reese, Li Di, Jisun Lee, Lisa Aschenbrenner, Stephen Noell, Lawrence W. Updyke, Martin Pettersson, Scott A. Gibson, Matthew F. Sammons, Al E. Stewart, Yuao Zhu, Alyssa Dantonio, Stephen W. Mason, Brett L. Hurst, Ketan S. Gajiwala, Claire M. Steppan, Liuqing Wei, Patrick Robert Verhoest, Samantha Elizabeth Greasley, Simon Berritt, R. Scott Obach, RoseAnn Ferre, Ravi Shankar P. Singh, Amit S. Kalgutkar, Jonathan J. Novak, Kevin Ogilvie, Wei Liu, Jamison B. Tuttle
Publikováno v:
Science. 374:1586-1593
Path to another drug against COVID-19 The rapid development of vaccines has been crucial in battling the ongoing COVID-19 pandemic. However, access challenges remain, breakthrough infections occur, and emerging variants present increased risk. Develo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::afda196cafc9555c41b81b6f1866c49a
https://doi.org/10.1126/science.abl4784
https://doi.org/10.1126/science.abl4784
Autor:
Dafydd R, Owen, Charlotte M N, Allerton, Annaliesa S, Anderson, Lisa, Aschenbrenner, Melissa, Avery, Simon, Berritt, Britton, Boras, Rhonda D, Cardin, Anthony, Carlo, Karen J, Coffman, Alyssa, Dantonio, Li, Di, Heather, Eng, RoseAnn, Ferre, Ketan S, Gajiwala, Scott A, Gibson, Samantha E, Greasley, Brett L, Hurst, Eugene P, Kadar, Amit S, Kalgutkar, Jack C, Lee, Jisun, Lee, Wei, Liu, Stephen W, Mason, Stephen, Noell, Jonathan J, Novak, R Scott, Obach, Kevin, Ogilvie, Nandini C, Patel, Martin, Pettersson, Devendra K, Rai, Matthew R, Reese, Matthew F, Sammons, Jean G, Sathish, Ravi Shankar P, Singh, Claire M, Steppan, Al E, Stewart, Jamison B, Tuttle, Lawrence, Updyke, Patrick R, Verhoest, Liuqing, Wei, Qingyi, Yang, Yuao, Zhu
Publikováno v:
Science (New York, N.Y.). 374(6575)
The worldwide outbreak of COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global pandemic. Alongside vaccines, antiviral therapeutics are an important part of the healthcare response to countering the ongo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::30510d29ff514de1e731667297649f17
https://pubmed.ncbi.nlm.nih.gov/34726479
https://pubmed.ncbi.nlm.nih.gov/34726479
Autor:
Alyssa Dantonio, Heather Eng, Nandini Chaturbhai Patel, Anthony Carlo, Liuqing Wei, Annaliesa S. Anderson, Ravi Shankar P. Singh, Lawrence W. Updyke, Amit S. Kalgutkar, Jamison B. Tuttle, Lisa Aschenbrenner, Simon Berritt, Ketan S. Gajiwala, Jack C. Lee, Devendra K. Rai, Martin Pettersson, Matthew R. Reese, Jisun Lee, Stephen W. Mason, Eugene P. Kadar, RoseAnn Ferre, Melissa Avery, Li Di, Charlotte Moira Norfor Allerton, R. Scott Obach, Scott A. Gibson, Stephen Noell, Patrick Robert Verhoest, Kevin Ogilvie, Jonathan J. Novak, Brett L. Hurst, Dafydd R. Owen, Rhonda D. Cardin, Wei Liu, Yuao Zhu, Karen J. Coffman, Claire M. Steppan, Jean G. Sathish, Samantha Elizabeth Greasley, Matthew F. Sammons, Qingyi Yang, Britton Boras, Al E. Stewart
The worldwide outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become an established global pandemic. Alongside vaccines, antiviral therapeutics are an important part of the he
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0de6febfa535f3995194517e34278b9
https://doi.org/10.1101/2021.07.28.21261232
https://doi.org/10.1101/2021.07.28.21261232
Autor:
Samantha E. Greasley, Stephen Noell, Olga Plotnikova, RoseAnn Ferre, Wei Liu, Ben Bolanos, Kimberly Fennell, Jennifer Nicki, Tim Craig, Yuao Zhu, Al E. Stewart, Claire M. Steppan
Publikováno v:
Journal of Biological Chemistry. 298:101972
The COVID-19 pandemic continues to be a public health threat with emerging variants of SARS-CoV-2. Nirmatrelvir (PF-07321332) is a reversible, covalent inhibitor targeting the main protease (M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ea1b482d6a390935cf29ac08a2b3881
https://doi.org/10.1016/j.jbc.2022.101972
https://doi.org/10.1016/j.jbc.2022.101972
Autor:
Xiaoli Wang, Stephan Grant, Rita Grantner, Ben Bolaños, Casey L. Quinlan, Stephen E. Kaiser, Shannon Karlicek-Bryant, Stephen Jenkinson, Valeria R Fantin, Peter A. Wells, Jun Li Feng, Stephen Dann, Al E. Stewart, Nowlin Dawn Marie, Kevin Daniel Freeman-Cook
Publikováno v:
Nature Chemical Biology. 13:785-792
S-Adenosyl-L-methionine (SAM) is an enzyme cofactor used in methyl transfer reactions and polyamine biosynthesis. The biosynthesis of SAM from ATP and L-methionine is performed by the methionine adenosyltransferase enzyme family (Mat; EC 2.5.1.6). Hu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ff868d879f490f612b5686abb0517c0
https://doi.org/10.1038/nchembio.2384
https://doi.org/10.1038/nchembio.2384
Autor:
Pei-Pei Kung, Ya-Li Deng, Alexei Brooun, Xiu Yu, Wade Diehl, You-Ai He, Ketan S. Gajiwala, Ben Bolaños, Al E. Stewart, Wei Liu, Sutton Scott Channing, Patrick Bingham, Nicole Grable, Karen A. Maegley
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Nature Communications
Nature Communications
Polycomb repressive complex 2 (PRC2) mediates gene silencing through chromatin reorganization by methylation of histone H3 lysine 27 (H3K27). Overexpression of the complex and point mutations in the individual subunits of PRC2 have been shown to cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cac468a0221fc66da2d00c67fba4f58f
https://doaj.org/article/845df6d19e6c440e8657bbebe46e34a8
https://doaj.org/article/845df6d19e6c440e8657bbebe46e34a8
Autor:
Sergei Timofeevski, Junli Feng, Neil B. Grodsky, Meirong Xu, Ben Bolaños, Brion W. Murray, Ted William Johnson, RoseAnn Ferre, Al E. Stewart, Ketan S. Gajiwala
Publikováno v:
The Journal of biological chemistry. 292(38)
The receptor tyrosine kinase family consisting of Tyro3, Axl, and Mer (TAM) is one of the most recently identified receptor tyrosine kinase families. TAM receptors are up-regulated postnatally and maintained at high levels in adults. They all play an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::880f53f3e890e91339d25ec4dbb5d2be
https://pubmed.ncbi.nlm.nih.gov/28724631
https://pubmed.ncbi.nlm.nih.gov/28724631