Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Al C. Ngai"'
Autor:
Cordelie E. Witt, Abhineet Chowdhary, Thien Son K Nguyen, Gavin W. Britz, Al C. Ngai, Ik Seong Park, Joseph R. Meno, H. Richard Winn
Publikováno v:
Journal of Neurosurgery. 111:1008-1013
Object Cerebrovascular dysfunction after subarachnoid hemorrhage (SAH) may contribute to ischemia, but little is known about the contribution of intracerebral arterioles. In this study, the authors tested the hypothesis that SAH inhibits the vascular
Publikováno v:
Journal of Neurosurgery. 109:654-663
Object This study was undertaken to test the hypothesis that cerebral blood flow (CBF) and the intrinsic optical signal could be dissociated by altering adenosine receptor activity and to uncover the origin of the optic signal using a cranial window
Publikováno v:
Neonatology. 93:45-51
Chronic fetal alcohol exposure impairs neural and vascular development. We have previously shown that fetal alcohol exposure is associated with attenuated hypoxic cerebral vasodilation and reduced neuronal vasoactive intestinal peptide (VIP) expressi
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 284:H1631-H1637
We tested the hypothesis that adenosine (Ado) mediates glutamate-induced vasodilation in the cerebral cortex by monitoring pial arteriole diameter in chloralose-anesthetized rats equipped with closed cranial windows. Topical application of 100 μM gl
Autor:
Joseph R. Meno, Thien Son K Nguyen, Al C. Ngai, H. Richard Winn, J. Marc Simard, G. Alexander West
Publikováno v:
Journal of Cardiovascular Pharmacology. 41:444-451
Adenosine (ADO) is a potent cerebral vasodilator and has been proposed as a metabolic regulator of cerebral blood flow. However, the signal transduction pathway by which ADO causes vasodilation in cerebral microvessels is currently unknown. The curre
Publikováno v:
Journal of Neuroscience Methods. 120:145-153
Vascular control mechanisms have been studied extensively in mice. However, an in vitro characterization of penetrating intracerebral arterioles has not been reported. We describe methods for isolation and cannulation for mouse intracerebral arteriol
Autor:
Al C. Ngai, H. Richard Winn
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 282:H902-H907
Pial arterioles supplying the hindlimb somatosensory cortex dilate in response to contralateral sciatic nerve stimulation. The mechanism of this pial vasodilation is not well understood. One possibility is that vasoactive metabolites released during
Publikováno v:
Neuroscience Letters. 245:171-174
We have previously shown that topically applied N G -nitro- l -arginine ( l -NNA), a nitric oxide synthase (NOS) inhibitor, suppressed both somatosensory evoked potentials (SEPs) and vascular responses during sciatic nerve stimulation in rats. Due to
Autor:
Al C. Ngai, H. R. Winn
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 270:H1712-H1717
We tested the hypothesis that a shear stress-dependent mechanism is involved in the dilation of pial arterioles during somatosensory stimulation. In alpha-chloralose-anesthetized rats implanted with cranial windows, we simultaneously measured the dia
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 269:H1803-H1810
We studied the local cerebrovascular response and somatosensory-evoked potentials (SEPs) to stimulation of the sciatic nerve during both short- (< 30 min) and long-term (90-150 min) exposure to topically applied NG-nitro-L-arginine (L-NNA). The pial