Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Aléssio AC"'
Autor:
Lilia Leisle, Kin Lam, Sepehr Dehghani-Ghahnaviyeh, Eva Fortea, Jason D. Galpin, Christopher A. Ahern, Emad Tajkhorshid, Alessio Accardi
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
CLC-type channels selectively transport Cl− across biological membranes, but it is unclear how discrimination between anions is maintained. Here, authors use a combination of non-natural amino acid substitutions, electrophysiology, and molecular dy
Externí odkaz:
https://doaj.org/article/eabf06623768491494a18c38aba88802
Autor:
Maria E. Falzone, Zhang Feng, Omar E. Alvarenga, Yangang Pan, ByoungCheol Lee, Xiaolu Cheng, Eva Fortea, Simon Scheuring, Alessio Accardi
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Lipid scrambling is required for many cellular processes but the lipid-protein interactions that occur during transport are unknown. Using cryoEM and biochemical assays the authors show that membrane thinning is critical for lipid flipping.
Externí odkaz:
https://doaj.org/article/eb89ec895ead4ea1bd22a27cf17cce5f
Autor:
George Khelashvili, Maria E. Falzone, Xiaolu Cheng, Byoung-Cheol Lee, Alessio Accardi, Harel Weinstein
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
A membrane-exposed groove in Ca2+-gated TMEM16 scramblases forms the translocation pathway for ions and lipids. Here authors combine molecular dynamics with cryo-EM and functional assays to uncover the conformational transitions of the groove leading
Externí odkaz:
https://doaj.org/article/217f3e9521bd47ab84603e12a70c94d1
Autor:
Simon R. Bushell, Ashley C. W. Pike, Maria E. Falzone, Nils J. G. Rorsman, Chau M. Ta, Robin A. Corey, Thomas D. Newport, John C. Christianson, Lara F. Scofano, Chitra A. Shintre, Annamaria Tessitore, Amy Chu, Qinrui Wang, Leela Shrestha, Shubhashish M. M. Mukhopadhyay, James D. Love, Nicola A. Burgess-Brown, Rebecca Sitsapesan, Phillip J. Stansfeld, Juha T. Huiskonen, Paolo Tammaro, Alessio Accardi, Elisabeth P. Carpenter
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
TMEM16K is a member of the TMEM16 family of integral membrane proteins that are either lipid scramblases or chloride channels. Here the authors combine cell biology, electrophysiology measurements, X-ray crystallography, cryo-EM and MD simulations to
Externí odkaz:
https://doaj.org/article/602dd2cc133c49529d8807b7b0d875ca
Autor:
Lilia Leisle, Yanyan Xu, Eva Fortea, Sangyun Lee, Jason D Galpin, Malvin Vien, Christopher A Ahern, Alessio Accardi, Simon Bernèche
Publikováno v:
eLife, Vol 9 (2020)
The CLC family comprises H+-coupled exchangers and Cl- channels, and mutations causing their dysfunction lead to genetic disorders. The CLC exchangers, unlike canonical 'ping-pong' antiporters, simultaneously bind and translocate substrates through p
Externí odkaz:
https://doaj.org/article/c9ee0e91e4b94b3f972f512b0980c861
Autor:
Byoung-Cheol Lee, George Khelashvili, Maria Falzone, Anant K. Menon, Harel Weinstein, Alessio Accardi
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Some TMEM16 family members are Ca2+-dependent phospholipid scramblases, which also mediate non-selective ion transport; however, the mechanism how lipids permeate through the TMEM16 remains poorly understood. Here, the authors combine biochemical ass
Externí odkaz:
https://doaj.org/article/ae6b3950bcc946ad841e6d949d6d90e5
Akademický článek
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Akademický článek
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Autor:
Maria E Falzone, Jan Rheinberger, Byoung-Cheol Lee, Thasin Peyear, Linda Sasset, Ashleigh M Raczkowski, Edward T Eng, Annarita Di Lorenzo, Olaf S Andersen, Crina M Nimigean, Alessio Accardi
Publikováno v:
eLife, Vol 8 (2019)
The lipid distribution of plasma membranes of eukaryotic cells is asymmetric and phospholipid scramblases disrupt this asymmetry by mediating the rapid, nonselective transport of lipids down their concentration gradients. As a result, phosphatidylser
Externí odkaz:
https://doaj.org/article/d8de76d559d7421aaf3e8ebaa4d6e9a6
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
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