Monoclonal anti-light chain idiotype as a tumor-specific probe for human neoplastic B lymphocytes

Autor: Wrightham M, Al, Tutt, Mj, Glennie, Tj, Hamblin, Gt, Stevenson, Freda Stevenson

Publikováno v: Europe PubMed Central

Tumor cells from patients with B cell neoplasms often secrete small amounts of free monoclonal light chains that can be found in the urine. Such tumor-derived light chains of the lambda type from a patient with typical chronic lymphocytic leukemia ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f3e6a8b4d5803b5ad4afefa1a5b9175
https://pubmed.ncbi.nlm.nih.gov/2434161

Anti-idiotypic mechanisms involved in suppression of a mouse B cell lymphoma, BCL1

Autor: Andrew George, Al, Tutt, Fk, Stevenson

Publikováno v: Europe PubMed Central

Immunization of BALB/c mice with idiotypic IgM rescued by hybridization from the syngeneic BCL1 lymphoma protects specifically against challenge with tumor cells, with 83% surviving greater than 100 days compared with controls (38 +/- 10 days). Splee

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::26aeb2ae7c6ac00daba1a6e5864e764f
http://europepmc.org/abstract/med/3491853

FcγRIIB controls antibody-mediated target cell depletion by ITIM-independent mechanisms.

Autor: Simpson AP; Antibody and Vaccine Group, Centre for Cancer Immunology, School of Cancer Sciences, University of Southampton Faculty of Medicine, Southampton SO16 6YD, UK., Roghanian A; Antibody and Vaccine Group, Centre for Cancer Immunology, School of Cancer Sciences, University of Southampton Faculty of Medicine, Southampton SO16 6YD, UK; Institute for Life Sciences, University of Southampton, Southampton SO17 1BJ, UK., Oldham RJ; Antibody and Vaccine Group, Centre for Cancer Immunology, School of Cancer Sciences, University of Southampton Faculty of Medicine, Southampton SO16 6YD, UK., Chan HTC; Antibody and Vaccine Group, Centre for Cancer Immunology, School of Cancer Sciences, University of Southampton Faculty of Medicine, Southampton SO16 6YD, UK., Penfold CA; Antibody and Vaccine Group, Centre for Cancer Immunology, School of Cancer Sciences, University of Southampton Faculty of Medicine, Southampton SO16 6YD, UK., Kim HJ; Antibody and Vaccine Group, Centre for Cancer Immunology, School of Cancer Sciences, University of Southampton Faculty of Medicine, Southampton SO16 6YD, UK., Inzhelevskaya T; Antibody and Vaccine Group, Centre for Cancer Immunology, School of Cancer Sciences, University of Southampton Faculty of Medicine, Southampton SO16 6YD, UK., Mockridge CI; Antibody and Vaccine Group, Centre for Cancer Immunology, School of Cancer Sciences, University of Southampton Faculty of Medicine, Southampton SO16 6YD, UK., Cox KL; Antibody and Vaccine Group, Centre for Cancer Immunology, School of Cancer Sciences, University of Southampton Faculty of Medicine, Southampton SO16 6YD, UK., Bogdanov YD; Antibody and Vaccine Group, Centre for Cancer Immunology, School of Cancer Sciences, University of Southampton Faculty of Medicine, Southampton SO16 6YD, UK., James S; Antibody and Vaccine Group, Centre for Cancer Immunology, School of Cancer Sciences, University of Southampton Faculty of Medicine, Southampton SO16 6YD, UK., Tutt AL; Antibody and Vaccine Group, Centre for Cancer Immunology, School of Cancer Sciences, University of Southampton Faculty of Medicine, Southampton SO16 6YD, UK., Rycroft D; Biopharm Discovery, GSK, Gunnels Wood Road, Stevenage SG1 2NY, UK., Morley P; Biopharm Discovery, GSK, Gunnels Wood Road, Stevenage SG1 2NY, UK., Dahal LN; Antibody and Vaccine Group, Centre for Cancer Immunology, School of Cancer Sciences, University of Southampton Faculty of Medicine, Southampton SO16 6YD, UK., Teige I; BioInvent International AB, Sölvegatan 41, 22370 Lund, Sweden., Frendeus B; BioInvent International AB, Sölvegatan 41, 22370 Lund, Sweden. Electronic address: bjorn.frendeus@bioinvent.com., Beers SA; Antibody and Vaccine Group, Centre for Cancer Immunology, School of Cancer Sciences, University of Southampton Faculty of Medicine, Southampton SO16 6YD, UK. Electronic address: sab@soton.ac.uk., Cragg MS; Antibody and Vaccine Group, Centre for Cancer Immunology, School of Cancer Sciences, University of Southampton Faculty of Medicine, Southampton SO16 6YD, UK; Institute for Life Sciences, University of Southampton, Southampton SO17 1BJ, UK. Electronic address: msc@soton.ac.uk.

Publikováno v: Cell reports [Cell Rep] 2022 Jul 19; Vol. 40 (3), pp. 111099.

Detection of Experimental and Clinical Immune Complexes by Measuring SHIP-1 Recruitment to the Inhibitory FcγRIIB.

Autor: Stopforth RJ; Antibody and Vaccine Group, Cancer Sciences Unit, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, United Kingdom., Oldham RJ; Antibody and Vaccine Group, Cancer Sciences Unit, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, United Kingdom., Tutt AL; Antibody and Vaccine Group, Cancer Sciences Unit, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, United Kingdom., Duriez P; Southampton Experimental Cancer Medicine/Cancer Research U.K. Centre, Protein Core Facility, Cancer Sciences Unit, Southampton General Hospital, Southampton SO16 6YD, United Kingdom., Chan HTC; Antibody and Vaccine Group, Cancer Sciences Unit, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, United Kingdom., Binkowski BF; Promega Corp., Fitchburg, WI 53711., Zimprich C; Promega Corp., Fitchburg, WI 53711., Li D; Promega Corp., Fitchburg, WI 53711., Hargreaves PG; Promega UK Ltd., Southampton Science Park, Southampton SO16 7NS, United Kingdom., Cong M; Promega Corp., Fitchburg, WI 53711., Reddy V; Division of Medicine, Centre for Rheumatology, University College London, London WC1E 6JF, United Kingdom; and., Leandro MJ; Division of Medicine, Centre for Rheumatology, University College London, London WC1E 6JF, United Kingdom; and., Cambridge G; Division of Medicine, Centre for Rheumatology, University College London, London WC1E 6JF, United Kingdom; and., Lux A; Department of Biology, University of Erlangen-Nuremberg, 91058 Erlangen, Germany., Nimmerjahn F; Department of Biology, University of Erlangen-Nuremberg, 91058 Erlangen, Germany., Cragg MS; Antibody and Vaccine Group, Cancer Sciences Unit, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, United Kingdom; msc@soton.ac.uk.

Publikováno v: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2018 Mar 01; Vol. 200 (5), pp. 1937-1950. Date of Electronic Publication: 2018 Jan 19.

Anti-mouse FcγRIV antibody 9E9 also blocks FcγRIII in vivo.

Autor: Tipton TR; Antibody and Vaccine Group, Cancer Sciences Unit, University of Southampton Faculty of Medicine, Southampton, United Kingdom., Mockridge CI; Antibody and Vaccine Group, Cancer Sciences Unit, University of Southampton Faculty of Medicine, Southampton, United Kingdom., French RR; Antibody and Vaccine Group, Cancer Sciences Unit, University of Southampton Faculty of Medicine, Southampton, United Kingdom., Tutt AL; Antibody and Vaccine Group, Cancer Sciences Unit, University of Southampton Faculty of Medicine, Southampton, United Kingdom., Cragg MS; Antibody and Vaccine Group, Cancer Sciences Unit, University of Southampton Faculty of Medicine, Southampton, United Kingdom., Beers SA; Antibody and Vaccine Group, Cancer Sciences Unit, University of Southampton Faculty of Medicine, Southampton, United Kingdom.

Publikováno v: Blood [Blood] 2015 Dec 10; Vol. 126 (24), pp. 2643-5. Date of Electronic Publication: 2015 Oct 22.