Antibodies against urinary light chain idiotypes as agents for detection and destruction of human neoplastic B lymphocytes

Autor: Al, Tutt, Freda Stevenson, Jl, Smith, Gt, Stevenson

Publikováno v: Europe PubMed Central

Patients with B cell neoplasms frequently have low levels of tumor-related light chains in their urine; these light chains can be isolated with the use of relatively simple methods and then used to raise antibodies to the idiotypic determinants. In t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::32f674d08f34bd9bdc4cdefe4a4ff453
https://pubmed.ncbi.nlm.nih.gov/6417240

Involvement of innate and induced anti-idiotypic mechanisms in suppression of B cell tumors

Autor: Fk, Stevenson, Andrew George, Al, Tutt, Mj, Glennie, Gt, Stevenson

Publikováno v: Europe PubMed Central

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::82d984e08648cc89b240ceaa43de9324
https://pubmed.ncbi.nlm.nih.gov/3501833

Monoclonal antibody therapy of B cell lymphoma: signaling activity on tumor cells appears more important than recruitment of effectors

Autor: Al, Tutt, Rr, French, Tim Illidge, Honeychurch J, Hm, Mcbride, Ca, Penfold, Dt, Fearon, Rm, Parkhouse, Gg, Klaus, Mj, Glennie

Publikováno v: Europe PubMed Central

Despite the recent success of mAb in the treatment of certain malignancies, there is still considerable uncertainty about the mechanism of action of anti-cancer Abs. Here, a panel of rat anti-mouse B cell mAb, including Ab directed at surface IgM Id,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::9ac22793628dba977cfebc8a13656981
http://europepmc.org/abstract/med/9743386

Recombinant antigen delivery to dendritic cells as a way to improve vaccine design.

Autor: de Souza-Silva, Guilherme Antonio, Sulczewski, Fernando Bandeira, Boscardin, Silvia Beatriz

Publikováno v: Experimental Biology & Medicine; Oct2023, Vol. 248 Issue 19, p1616-1623, 8p

Liver tropism of ER mutant breast cancer is characterized by unique molecular changes and immune infiltration.

Autor: Wu Y; School of Medicine, Tsinghua University, Beijing, China.; Women's Cancer Research Center, UPMC Hillman Cancer Center, Magee-Womens Research Institute, Pittsburgh, PA, USA., Li Z; Women's Cancer Research Center, UPMC Hillman Cancer Center, Magee-Womens Research Institute, Pittsburgh, PA, USA.; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA., Lee AV; Women's Cancer Research Center, UPMC Hillman Cancer Center, Magee-Womens Research Institute, Pittsburgh, PA, USA.; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA.; Institute for Precision Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Oesterreich S; Women's Cancer Research Center, UPMC Hillman Cancer Center, Magee-Womens Research Institute, Pittsburgh, PA, USA.; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA., Luo B; Department of General Surgery, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, 102218, China. luobin@mail.tsinghua.edu.cn.

Publikováno v: Breast cancer research and treatment [Breast Cancer Res Treat] 2024 Jun; Vol. 205 (2), pp. 371-386. Date of Electronic Publication: 2024 Mar 01.