Cigarette Smoke-Induced Epithelial-to-Mesenchymal Transition: Insights into Cellular Mechanisms and Signaling Pathways.

Autor: Alqithami, Sarah Mohammed¹ (AUTHOR) sarah.alqithami@uky.edu, Machwe, Amrita¹ (AUTHOR), Orren, David K.¹ (AUTHOR)

Publikováno v: Cells (2073-4409). Sep2024, Vol. 13 Issue 17, p1453. 17p.

NF1^+/ex42del miniswine model the cellular disruptions and behavioral presentations of NF1‐associated cognitive and motor impairment.

Autor: Swier, Vicki J.¹ (AUTHOR), White, Katherine A.¹ (AUTHOR), Negrão de Assis, Pedro L.¹ (AUTHOR), Johnson, Tyler B.¹ (AUTHOR), Leppert, Hannah G.¹ (AUTHOR), Rechtzigel, Mitchell J.¹ (AUTHOR), Meyerholz, David K.² (AUTHOR), Dodd, Rebecca D.^3,4 (AUTHOR), Quelle, Dawn E.⁵ (AUTHOR), Khanna, Rajesh⁶ (AUTHOR), Rogers, Christopher S.⁷ (AUTHOR), Weimer, Jill M.^1,8 (AUTHOR) jill.weimer@sanfordhealth.org

Publikováno v: CTS: Clinical & Translational Science. Jun2024, Vol. 17 Issue 6, p1-14. 14p.

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Oxidative stress-induced JNK/AP-1 signaling is a major pathway involved in selective apoptosis of myelodysplastic syndrome cells by Withaferin-A.

Autor: Oben KZ; Markey Cancer Center and Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, Lexington, KY 40536, USA., Alhakeem SS; Markey Cancer Center and Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, Lexington, KY 40536, USA., McKenna MK; Markey Cancer Center and Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, Lexington, KY 40536, USA., Brandon JA; Department of Internal Medicine, University of Kentucky, Lexington, KY 40536, USA., Mani R; Comprehensive Cancer Center and Department of Internal Medicine, Ohio State University, Columbus, OH 43210, USA., Noothi SK; Markey Cancer Center and Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, Lexington, KY 40536, USA., Jinpeng L; Biostatistics Core, Markey Cancer Center, University of Kentucky, Lexington, KY 40536, USA., Akunuru S; Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center and University of Cincinnati, Cincinnati, OH 45229, USA., Dhar SK; Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY 40536, USA., Singh IP; Department of Natural Products, National Institute of Pharmaceutical Research, S.A.S Nagar, Punjab 160062, India., Liang Y; Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY 40536, USA., Wang C; Biostatistics Core, Markey Cancer Center, University of Kentucky, Lexington, KY 40536, USA., Abdel-Latif A; Department of Internal Medicine, University of Kentucky, Lexington, KY 40536, USA., Stills HF Jr; Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, Lexington, KY 40536, USA., St Clair DK; Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY 40536, USA., Geiger H; Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center and University of Cincinnati, Cincinnati, OH 45229, USA., Muthusamy N; Comprehensive Cancer Center and Department of Internal Medicine, Ohio State University, Columbus, OH 43210, USA., Tohyama K; Department of Laboratory Medicine, Kawasaki Medical School, Kurashiki, Okayama 701-0192, Japan., Gupta RC; Department of Pharmacology and Toxicology, and James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA., Bondada S; Markey Cancer Center and Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, Lexington, KY 40536, USA.

Publikováno v: Oncotarget [Oncotarget] 2017 Aug 24; Vol. 8 (44), pp. 77436-77452. Date of Electronic Publication: 2017 Aug 24 (Print Publication: 2017).

Ubiquitination of hnRNPA1 by TRAF6 links chronic innate immune signaling with myelodysplasia.

Autor: Fang J; Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA., Bolanos LC; Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA., Choi K; Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA., Liu X; Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA., Christie S; Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA., Akunuru S; Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA., Kumar R; Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA., Wang D; Division of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA., Chen X; Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA., Greis KD; Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA., Stoilov P; Department of Biochemistry, West Virginia University, Morgantown, West Virginia, USA., Filippi MD; Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA., Maciejewski JP; Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA., Garcia-Manero G; Department of Leukemia, Maryland Anderson Cancer Center, Houston, Texas., Weirauch MT; Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.; Division of Biomedical Informatics, Cincinnati Children's Hospital Research Medical Center, Cincinnati, Ohio, USA.; Division of Developmental Biology, Cincinnati Children's Hospital Research Medical Center, Cincinnati, Ohio, USA., Salomonis N; Division of Biomedical Informatics, Cincinnati Children's Hospital Research Medical Center, Cincinnati, Ohio, USA., Geiger H; Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA., Zheng Y; Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA., Starczynowski DT; Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.; Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

Publikováno v: Nature immunology [Nat Immunol] 2017 Feb; Vol. 18 (2), pp. 236-245. Date of Electronic Publication: 2016 Dec 26.