Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Akul Singhania"'
Autor:
Hannah Hillman, Nabeela Khan, Akul Singhania, Paige Dubelko, Ferran Soldevila, Rashmi Tippalagama, Aruna D. DeSilva, Bandu Gunasena, Judy Perera, Thomas J. Scriba, Cynthia Ontong, Michelle Fisher, Angelique Luabeya, Randy Taplitz, Gregory Seumois, Pandurangan Vijayanand, Catherine C. Hedrick, Bjoern Peters, Julie G. Burel
Publikováno v:
Frontiers in Immunology, Vol 13 (2023)
IntroductionPrevious studies suggest that monocytes are an important contributor to tuberculosis (TB)-specific immune signatures in blood.MethodsHere, we carried out comprehensive single-cell profiling of monocytes in paired blood samples of active T
Externí odkaz:
https://doaj.org/article/fd2683604621403589ee1f57436e33e4
Autor:
Akul Singhania, John Pham, Rekha Dhanwani, April Frazier, Juliana Rezende Dutra, Karen S. Marder, Elizabeth Phillips, Simon Mallal, Amy W. Amara, David G. Standaert, David Sulzer, Bjoern Peters, Alessandro Sette, Cecilia S. Lindestam Arlehamn
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract The self-antigen α-synuclein (α-syn) was recently shown to be associated with Parkinson’s disease (PD). Here we mapped the T cell receptor (TCR) repertoire of α-syn-specific T cells from six PD patients. The self-antigen α-syn-specific
Externí odkaz:
https://doaj.org/article/318a19c555da466f96aa22f94ae2ea3c
Autor:
Akul Singhania, Paige Dubelko, Rebecca Kuan, William D. Chronister, Kaylin Muskat, Jyotirmoy Das, Elizabeth J. Phillips, Simon A. Mallal, Grégory Seumois, Pandurangan Vijayanand, Alessandro Sette, Maria Lerm, Bjoern Peters, Cecilia Lindestam Arlehamn
Publikováno v:
EBioMedicine, Vol 74, Iss , Pp 103746- (2021)
Background: The century-old Mycobacterium bovis Bacillus Calmette-Guerin (BCG) remains the only licensed vaccine against tuberculosis (TB). Despite this, there is still a lot to learn about the immune response induced by BCG, both in terms of phenoty
Externí odkaz:
https://doaj.org/article/9dab5dae98fb49659fa0e714ba345e15
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 10, p e1009459 (2021)
Recent technological advances have made the gathering of comprehensive gene expression datasets a commodity. This has shifted the limiting step of transcriptomic studies from the accumulation of data to their analyses and interpretation. The main pro
Externí odkaz:
https://doaj.org/article/2b76c97381b7453c92f5082552e84bb9
Autor:
Akul Singhania, Christine M. Graham, Leona Gabryšová, Lúcia Moreira-Teixeira, Evangelos Stavropoulos, Jonathan M. Pitt, Probir Chakravarty, Annika Warnatsch, William J. Branchett, Laura Conejero, Jing-Wen Lin, Sophia Davidson, Mark S. Wilson, Gregory Bancroft, Jean Langhorne, Eva Frickel, Abdul K. Sesay, Simon L. Priestnall, Eleanor Herbert, Marianna Ioannou, Qian Wang, Ian R. Humphreys, Jonathan Dodd, Peter J. M. Openshaw, Katrin D. Mayer-Barber, Dragana Jankovic, Alan Sher, Clare M. Lloyd, Nicole Baldwin, Damien Chaussabel, Venizelos Papayannopoulos, Andreas Wack, Jacques F. Banchereau, Virginia M. Pascual, Anne O’Garra
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-21 (2019)
The authors present an extensive profile of host transcriptional respones to a diverse group of pathogens and allergens. In doing so, they identify TH1, type I IFN, TH17, and TH2 responses, that underlie each immune response in both the blood and lun
Externí odkaz:
https://doaj.org/article/2de9148c41624ebdb261719be7a52d90
Autor:
Akul Singhania, Raman Verma, Christine M. Graham, Jo Lee, Trang Tran, Matthew Richardson, Patrick Lecine, Philippe Leissner, Matthew P. R. Berry, Robert J. Wilkinson, Karine Kaiser, Marc Rodrigue, Gerrit Woltmann, Pranabashis Haldar, Anne O’Garra
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Mass screening diagnostics for Mycobacterium tuberculosis exist, but criticisms exist regarding the sensitivity and specificity of these tools. Here the authors use RNA-Seq and a modular bioinformatics approach using data from their own cohorts and m
Externí odkaz:
https://doaj.org/article/f00dac82845249b8a6fa26d64cff3275
Autor:
Akul Singhania, Hitasha Rupani, Nivenka Jayasekera, Simon Lumb, Paul Hales, Neil Gozzard, Donna E Davies, Christopher H Woelk, Peter H Howarth
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0168680 (2017)
Management of severe asthma remains a challenge despite treatment with glucocorticosteroid therapy. The majority of studies investigating disease mechanisms in treatment-resistant severe asthma have previously focused on the large central airways, wi
Externí odkaz:
https://doaj.org/article/dfeb7c410dfd43f6b476ae9e263705dc
Autor:
Tarangini Sathyamoorthy, Gurjinder Sandhu, Liku B Tezera, Richard Thomas, Akul Singhania, Christopher H Woelk, Borislav D Dimitrov, Dan Agranoff, Carlton A W Evans, Jon S Friedland, Paul T Elkington
Publikováno v:
PLoS ONE, Vol 10, Iss 1, p e0117605 (2015)
Tuberculosis (TB) remains a global health pandemic and greater understanding of underlying pathogenesis is required to develop novel therapeutic and diagnostic approaches. Matrix metalloproteinases (MMPs) are emerging as key effectors of tissue destr
Externí odkaz:
https://doaj.org/article/9a184e70f308453f9f734e7109855b1d
Autor:
Celsa A Spina, Jenny Anderson, Nancie M Archin, Alberto Bosque, Jonathan Chan, Marylinda Famiglietti, Warner C Greene, Angela Kashuba, Sharon R Lewin, David M Margolis, Matthew Mau, Debbie Ruelas, Suha Saleh, Kotaro Shirakawa, Robert F Siliciano, Akul Singhania, Paula C Soto, Valeri H Terry, Eric Verdin, Christopher Woelk, Stacey Wooden, Sifei Xing, Vicente Planelles
Publikováno v:
PLoS Pathogens, Vol 9, Iss 12, p e1003834 (2013)
The possibility of HIV-1 eradication has been limited by the existence of latently infected cellular reservoirs. Studies to examine control of HIV latency and potential reactivation have been hindered by the small numbers of latently infected cells f
Externí odkaz:
https://doaj.org/article/c1b7a515bcb647878a1e618d655578b3
Autor:
David Gallo, Jordan T. F. Young, Jimmy Fourtounis, Giovanni Martino, Alejandro Álvarez-Quilón, Cynthia Bernier, Nicole M. Duffy, Robert Papp, Anne Roulston, Rino Stocco, Janek Szychowski, Artur Veloso, Hunain Alam, Prasamit S. Baruah, Alexanne Bonneau Fortin, Julian Bowlan, Natasha Chaudhary, Jessica Desjardins, Evelyne Dietrich, Sara Fournier, Chloe Fugère-Desjardins, Theo Goullet de Rugy, Marie-Eve Leclaire, Bingcan Liu, Vivek Bhaskaran, Yael Mamane, Henrique Melo, Olivier Nicolas, Akul Singhania, Rachel K. Szilard, Ján Tkáč, Shou Yun Yin, Stephen J. Morris, Michael Zinda, C. Gary Marshall, Daniel Durocher
Publikováno v:
Nature. 604:749-756
Amplification of the CCNE1 locus on chromosome 19q12 is prevalent in multiple tumour types, particularly in high-grade serous ovarian cancer, uterine tumours and gastro-oesophageal cancers, where high cyclin E levels are associated with genome instab