Obesity differs from diabetes mellitus in antibody and T-cell responses post-COVID-19 recovery.

Autor: Ali M; Peter Medawar Building for Pathogen Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.; Centre for Global Health Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.; Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand.; Directorate General of Health Services, Dhaka, Bangladesh.; Department of Biochemistry and Molecular Biology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh., Longet S; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Neale I; Peter Medawar Building for Pathogen Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.; Centre for Global Health Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.; Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand., Rongkard P; Peter Medawar Building for Pathogen Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.; Centre for Global Health Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.; Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand., Chowdhury FUH; Department of Internal Medicine, Dhaka Medical College, Dhaka, Bangladesh., Hill J; Peter Medawar Building for Pathogen Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.; Centre for Global Health Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.; Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand., Brown A; Peter Medawar Building for Pathogen Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK., Laidlaw S; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Tipton T; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Hoque A; Department of Transfusion Medicine, Sheikh Hasina National Burn & Plastics Surgery Institute, Dhaka, Bangladesh., Hassan N; Department of Internal Medicine, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh., Hackstein CP; Peter Medawar Building for Pathogen Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.; Translational Gastroenterology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK., Adele S; Peter Medawar Building for Pathogen Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.; Centre for Global Health Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.; Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand., Akther HD; Peter Medawar Building for Pathogen Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.; Translational Gastroenterology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK., Abraham P; Peter Medawar Building for Pathogen Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.; Centre for Global Health Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.; Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand., Paul S; Department of Internal Medicine, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh., Rahman MM; Department of Biochemistry and Molecular Biology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh., Alam MM; Department of Biochemistry and Molecular Biology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh., Parvin S; Department of Biochemistry and Molecular Biology, Mugda Medical College, Dhaka, Bangladesh., Mollah FH; Department of Biochemistry and Molecular Biology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh., Hoque MM; Department of Biochemistry and Molecular Biology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh., Moore SC; Tropical and Infectious Disease Unit, Liverpool University Hospitals NHS Foundation Trust, Member of Liverpool Health Partners, Liverpool, UK., Biswas SK; Department of Biochemistry and Molecular Biology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.; Department of Molecular and Cell Biology, University of Connecticut, Storrs, Connecticut, USA., Turtle L; Tropical and Infectious Disease Unit, Liverpool University Hospitals NHS Foundation Trust, Member of Liverpool Health Partners, Liverpool, UK., de Silva TI; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, UK., Ogbe A; Peter Medawar Building for Pathogen Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK., Frater J; Peter Medawar Building for Pathogen Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK., Barnes E; Peter Medawar Building for Pathogen Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.; Centre for Global Health Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.; NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Tomic A; National Emerging Infectious Diseases Laboratories, Boston University, Boston, MA, USA.; Department of Microbiology, Boston University School of Medicine, Boston, MA, USA.; Department of Biomedical Engineering, Boston University, Boston, MA, USA., Carroll MW; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Klenerman P; Peter Medawar Building for Pathogen Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.; Centre for Global Health Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.; Translational Gastroenterology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.; NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Kronsteiner B; Peter Medawar Building for Pathogen Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.; Centre for Global Health Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.; Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand., Chowdhury FR; Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand.; Department of Internal Medicine, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh., Dunachie SJ; Peter Medawar Building for Pathogen Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.; Centre for Global Health Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.; Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand.; NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.

Publikováno v: Clinical and experimental immunology [Clin Exp Immunol] 2024 Sep 16; Vol. 218 (1), pp. 78-92.

Treatment of COVID-19 with remdesivir in the absence of humoral immunity: a case report.

Autor: Buckland MS; Department of Clinical Immunology, Barts Health, London, UK. m.buckland@ucl.ac.uk.; UCL GOSH Institute of Child Health Division of Infection and Immunity, Section of Cellular and Molecular Immunology, London, UK. m.buckland@ucl.ac.uk., Galloway JB; Centre for Rheumatic Diseases, King's College London, London, UK., Fhogartaigh CN; Department of Infection, Barts Health NHS Trust, London, UK., Meredith L; Department of Pathology, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK., Provine NM; Peter Medawar Building for Pathogen Research, South Parks Rd, Oxford, OX1 3SY, UK.; Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK., Bloor S; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, Cambridge, UK.; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, UK., Ogbe A; Peter Medawar Building for Pathogen Research, South Parks Rd, Oxford, OX1 3SY, UK.; Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK., Zelek WM; Systems Immunity Institute and Dementia Research Institute, Cardiff University, Cardiff, UK., Smielewska A; Division of Virology, Department of Pathology, University of Cambridge, Addenbrookes Hospital, Cambridge, UK.; PHE - Public Health England Laboratory, Cambridge. Box 236, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge, UK., Yakovleva A; Department of Pathology, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK., Mann T; Medical Research Council Toxicology Unit, University of Cambridge, Gleeson Building, Tennis Court Road, Cambridge, CB2 1QW, UK., Bergamaschi L; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, Cambridge, UK.; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, UK., Turner L; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, Cambridge, UK.; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, UK., Mescia F; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, Cambridge, UK.; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, UK., Toonen EJM; R&D Department, Hycult Biotechnology, Frontstraat 2A, 5405 PB, Uden, The Netherlands., Hackstein CP; Peter Medawar Building for Pathogen Research, South Parks Rd, Oxford, OX1 3SY, UK.; Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK., Akther HD; Peter Medawar Building for Pathogen Research, South Parks Rd, Oxford, OX1 3SY, UK.; Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK., Vieira VA; Peter Medawar Building for Pathogen Research, South Parks Rd, Oxford, OX1 3SY, UK.; Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK., Ceron-Gutierrez L; Department of Clinical Biochemistry and Immunology, Addenbrooke's Hospital, Cambridge, UK., Periselneris J; Respiratory Department, King's College Hospital NHS Foundation Trust, UK. Department of Clinical Virology, Addenbrookes, UK., Kiani-Alikhan S; Department of Clinical Immunology, Barts Health, London, UK., Grigoriadou S; Department of Clinical Immunology, Barts Health, London, UK., Vaghela D; Department of Infectious Diseases, Cambridge University Hospitals NHS Trust, Cambridge, UK., Lear SE; Department of Immunology, Cambridge University Hospitals NHS Trust, Cambridge, UK., Török ME; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, Cambridge, UK.; Cambridge University Hospitals NHS Foundation Trust, Department of Microbiology, Cambridge, UK., Hamilton WL; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, Cambridge, UK.; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Stockton J; Institute of Microbiology and Infection, University of Birmingham, Birmingham, UK., Quick J; Institute of Microbiology and Infection, University of Birmingham, Birmingham, UK., Nelson P; Belfast Health and Social Care Trust, Belfast, Northern Ireland, UK., Hunter M; Belfast Health and Social Care Trust, Belfast, Northern Ireland, UK., Coulter TI; Belfast Health and Social Care Trust, Belfast, Northern Ireland, UK.; Regional Immunology Service, Belfast Health and Social Care Trust, Belfast, Northern Ireland, UK., Devlin L; Belfast Health and Social Care Trust, Belfast, Northern Ireland, UK.; Regional Immunology Service, Belfast Health and Social Care Trust, Belfast, Northern Ireland, UK., Bradley JR; NIHR BioResource and NIHR Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, Cambridge, UK., Smith KGC; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, Cambridge, UK.; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, UK., Ouwehand WH; Department of Haematology, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, UK.; NHS Blood and Transplant, Cambridge Biomedical Campus, Cambridge, UK., Estcourt L; NHS Blood and Transplant, Oxford, UK., Harvala H; NHS Blood and Transplant, London, UK., Roberts DJ; NHS Blood and Transplant, Oxford, UK.; Radcliffe Department of Medicine and BRC Haematology Theme, University of Oxford, John Radcliffe Hospital, Oxford, UK., Wilkinson IB; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, UK., Screaton N; Radiology, Papworth Hospital, Cambridge, UK., Loman N; Institute of Microbiology and Infection, University of Birmingham, Birmingham, UK., Doffinger R; Respiratory Department, King's College Hospital NHS Foundation Trust, UK. Department of Clinical Virology, Addenbrookes, UK., Lyons PA; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, Cambridge, UK.; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, UK., Morgan BP; Systems Immunity Institute and Dementia Research Institute, Cardiff University, Cardiff, UK., Goodfellow IG; Department of Pathology, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK., Klenerman P; Peter Medawar Building for Pathogen Research, South Parks Rd, Oxford, OX1 3SY, UK.; Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK., Lehner PJ; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, Cambridge, UK.; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, UK.; Department of Infectious Diseases, Cambridge University Hospitals NHS Trust, Cambridge, UK., Matheson NJ; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, Cambridge, UK. njm25@cam.ac.uk.; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, UK. njm25@cam.ac.uk.; Department of Infectious Diseases, Cambridge University Hospitals NHS Trust, Cambridge, UK. njm25@cam.ac.uk.; NHS Blood and Transplant, Cambridge Biomedical Campus, Cambridge, UK. njm25@cam.ac.uk., Thaventhiran JED; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, Cambridge, UK. jedt2@cam.ac.uk.; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, UK. jedt2@cam.ac.uk.; Medical Research Council Toxicology Unit, University of Cambridge, Gleeson Building, Tennis Court Road, Cambridge, CB2 1QW, UK. jedt2@cam.ac.uk.; Cancer Research UK Cambridge Institute, Cambridge Biomedical Campus, Cambridge, UK. jedt2@cam.ac.uk.

Publikováno v: Nature communications [Nat Commun] 2020 Dec 14; Vol. 11 (1), pp. 6385. Date of Electronic Publication: 2020 Dec 14.

TCR and Inflammatory Signals Tune Human MAIT Cells to Exert Specific Tissue Repair and Effector Functions.

Autor: Leng T; Peter Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, UK., Akther HD; Peter Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, UK; Translational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford, Oxford OX3 9DU, UK., Hackstein CP; Peter Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, UK; Translational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford, Oxford OX3 9DU, UK., Powell K; Peter Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, UK; Department of Microbiology and Immunology, University of Otago, Otago, New Zealand., King T; Peter Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, UK., Friedrich M; The Kennedy Institute of Rheumatology, Roosevelt Dr., Oxford OX3 7FY, UK., Christoforidou Z; Translational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford, Oxford OX3 9DU, UK., McCuaig S; The Kennedy Institute of Rheumatology, Roosevelt Dr., Oxford OX3 7FY, UK., Neyazi M; The Kennedy Institute of Rheumatology, Roosevelt Dr., Oxford OX3 7FY, UK., Arancibia-Cárcamo CV; Translational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford, Oxford OX3 9DU, UK., Hagel J; Peter Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, UK., Powrie F; The Kennedy Institute of Rheumatology, Roosevelt Dr., Oxford OX3 7FY, UK., Peres RS; The Kennedy Institute of Rheumatology, Roosevelt Dr., Oxford OX3 7FY, UK., Millar V; Target Discovery Institute, Roosevelt Dr., Oxford OX3 7FZ, UK., Ebner D; Target Discovery Institute, Roosevelt Dr., Oxford OX3 7FZ, UK., Lamichhane R; Department of Microbiology and Immunology, University of Otago, Otago, New Zealand., Ussher J; Department of Microbiology and Immunology, University of Otago, Otago, New Zealand., Hinks TSC; NIHR Biomedical Research Centre, John Radcliffe Hospital, Oxford OX3 9DU, UK; Respiratory Medicine Unit, Nuffield Department of Medicine Experimental Medicine, University of Oxford, Oxford OX3 9DU, UK; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC 3000, Australia., Marchi E; Peter Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, UK., Willberg C; Peter Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, UK., Klenerman P; Peter Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, UK; Translational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford, Oxford OX3 9DU, UK; NIHR Biomedical Research Centre, John Radcliffe Hospital, Oxford OX3 9DU, UK. Electronic address: paul.klenerman@medawar.ox.ac.uk.

Publikováno v: Cell reports [Cell Rep] 2019 Sep 17; Vol. 28 (12), pp. 3077-3091.e5.