Zobrazeno 1 - 10
of 1 237
pro vyhledávání: '"Akt inhibitor"'
Autor:
Siqi Liao, Qingliang Wang, Siyuan Chen, Qixuan Huang, Li Zhou, Hongtao Liu, Song He, Zhihang Zhou
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-16 (2024)
Abstract Background Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related mortality. Although multi-kinase inhibitors can prolong the overall survival of late-stage HCC patients, the emergence of drug resistance diminishes the
Externí odkaz:
https://doaj.org/article/0b74f70b3a82443383f9caf3674cfe45
Autor:
Mingqiang Shi, Zhoujuan Li, Guoshuang Shen, Tianzhuo Wang, Jinming Li, Miaozhou Wang, Zhen Liu, Fuxing Zhao, Dengfeng Ren, Jiuda Zhao
Publikováno v:
Cancer Pathogenesis and Therapy, Vol 2, Iss 2, Pp 81-90 (2024)
Background: Metastatic triple-negative breast cancer (mTNBC) is an aggressive histological subtype with poor prognosis. Several first-line treatments are currently available for mTNBC. This study conducted a network meta-analysis to compare these fir
Externí odkaz:
https://doaj.org/article/6439a61dbb12443393dd4799432f75d1
Autor:
Shaowei Bing, Senfeng Xiang, Zhimei Xia, Yilong Wang, Zhonghai Guan, Jinxin Che, Aixiao Xu, Xiaowu Dong, Ji Cao, Bo Yang, Jinhu Wang, Qiaojun He, Meidan Ying
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 4, Pp 1522-1536 (2023)
While neuroblastoma accounts for 15% of childhood tumor-related deaths, treatments against neuroblastoma remain scarce and mainly consist of cytotoxic chemotherapeutic drugs. Currently, maintenance therapy of differentiation induction is the standard
Externí odkaz:
https://doaj.org/article/b2100f0774934776a8465eff9442a731
Autor:
Diana I. Salnikova, Stepan K. Krymov, Danila V. Sorokin, Fedor B. Bogdanov, Olga E. Andreeva, Alvina I. Khamidullina, Andrey E. Shchekotikhin, Alexander M. Scherbakov
Publikováno v:
Proceedings, Vol 100, Iss 1, p 4 (2024)
Introduction: The design and development of antitumor compounds based on an isatin core led to the synthesis of 1-substituted isatin-5-sulfonamides with potent antiproliferative activity [...]
Externí odkaz:
https://doaj.org/article/1374ebb7d9014592ae7a54f751b6d95c
Autor:
Hao Feng, Ling Qiu, Zixiao Shi, Yao Sheng, Peipei Zhao, Di Zhou, Fei Li, Hailin Yu, Yanan You, Hui Wang, Ming Li, Shurong Zhu, Yan Du, Jun Cui, Jingwei Sun, Yarong Liu, Hua Jiang, Xin Wu
Publikováno v:
Cancer Medicine, Vol 12, Iss 3, Pp 3313-3327 (2023)
Abstract Introduction Adoptive cellular therapy with tumor‐infiltrating lymphocytes (TIL) has demonstrated promising clinical benefits in several solid tumors, but the efficacy of this therapy might be compromised by the “prone‐to‐exhaustion
Externí odkaz:
https://doaj.org/article/99fa77ab873e42639618fa69468134cb
Publikováno v:
Current Issues in Molecular Biology, Vol 44, Iss 12, Pp 6006-6014 (2022)
Frequent mutation of APC (90%) in advanced colorectal cancer (CRC) results in the simultaneous activation of Wnt/β-catenin and AKT signaling pathways, and the current therapeutic limitations of the AKT inhibitors for treating CRC patients are nuclea
Externí odkaz:
https://doaj.org/article/ae62cc3d6d2c4b8a90f9af1b5fd04e0c
Akademický článek
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Akademický článek
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Autor:
Angeliki Andrikopoulou, Spyridoula Chatzinikolaou, Evangelia Panourgias, Maria Kaparelou, Michalis Liontos, Meletios-Athanasios Dimopoulos, Flora Zagouri
Publikováno v:
Breast, Vol 63, Iss , Pp 157-167 (2022)
Over 50% of breast tumors harbor alterations in one or more genes of the phosphatidylinositol 3-kinase (PI3K) pathway including PIK3CA mutations (31%), PTEN loss (34%), PTEN mutations (5%) and AKT1 mutations (3%). While PI3K and mTOR inhibitors are a
Externí odkaz:
https://doaj.org/article/8df58a4ec1d34a92a5679c0ef578d266
Publikováno v:
Biomedicines, Vol 11, Iss 10, p 2652 (2023)
Glioblastoma multiforme (GBM) is the most lethal primary brain tumor in adults, characterized by a highly invasive nature and therapy resistance. Combination of menadione and ascorbic acid (AA+MD) exerts strong ROS-mediated anti-GBM activity in vitro
Externí odkaz:
https://doaj.org/article/d03336e844f04c9c9f2ea2e9e572ac62