Zobrazeno 1 - 10
of 113
pro vyhledávání: '"Akt Inhibitor MK2206"'
Autor:
Cheng Liu, Dan-dan Li, Fengling Ning, Lulu Tian, Xuemei Zhang, Mengling Wang, Hong Xin, Hui Cai, Svetlana Reilly, Jie Tao
Publikováno v:
Acta Pharmacol Sin
Vascular calcification (VC) is characterized by pathological depositions of calcium and phosphate in the arteries and veins via an active cell-regulated process, in which vascular smooth muscle cells (VSMCs) transform into osteoblast/chondrocyte-like
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c8c283fb5e86b31548dcacf21abbe6b
https://doi.org/10.1038/s41401-021-00704-6
https://doi.org/10.1038/s41401-021-00704-6
Autor:
Michael Linnebacher, Dominik Nörz, Daniel J Smit, Ole Thastrup, Manfred Jücker, Alp Mirdogan, Patrick Ehm, Andreas Block, Jakob R. Izbicki, Jacqueline Siekiera, Christina S Mullins, Grith Hagel
Publikováno v:
Anticancer Research. 41:2257-2275
Background Pre-therapeutic analysis of three-dimensional spheroid cultures of primary tumour samples is a promising approach of assessing susceptibility to potential treatment. The phosphatidylinositol-3-kinase/AKT serine/threonine kinase/mammalian t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b842bf0f8530547f9506fd38029e2801
https://doi.org/10.21873/anticanres.15002
https://doi.org/10.21873/anticanres.15002
Autor:
Meng-ya Shan, Ying Dai, Zihui Xu, Bin Chen, Kebin Zhang, Pei-Lin Li, Ling-Gong Zhao, Ji-Li Deng, Shaodong Guo
Publikováno v:
Journal of Cardiovascular Pharmacology. 76:246-254
Cardiac hypertrophy causes heart failure and is associated with hyperglycemia in patients with diabetes mellitus. Mibefradil, which acts as a T-type calcium channel blocker, exerts beneficial effects in patients with heart failure. In this study, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f0bfb153514a01a7be6f0d4427cd1fd
https://doi.org/10.1097/fjc.0000000000000844
https://doi.org/10.1097/fjc.0000000000000844
Publikováno v:
Biology of Reproduction. 103:779-790
Fibrinogen alpha chain (FGA), a cell adhesion molecule, contains two arginyl-glycyl-aspartic acid (RGD) cell adhesion sequences. Our previous study demonstrated that FGA, as an up-regulated protein in endometriosis (EM), was closely related to diseas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1b60fdfc48d1c79a82d7596fb1c4a2a
https://doi.org/10.1093/biolre/ioaa126
https://doi.org/10.1093/biolre/ioaa126
Publikováno v:
Journal of Cardiovascular Translational Research
Ischemia reperfusion (I/R)-induced arrhythmia is a serious complication in patients with cardiac infarction. Remodeling of connexin (Cx) 43, manifested as phosphorylation, contributes significantly to arrhythmogenesis. Integrin-linked kinase (ILK) at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::509a436583756fe3ded90bcbd4f6c2b6
https://doi.org/10.1007/s12265-020-09979-2
https://doi.org/10.1007/s12265-020-09979-2
Publikováno v:
Radiotherapy and Oncology, 149, pp. 1-7
Radiotherapy and Oncology, 149, 1-7
Radiotherapy and Oncology, 149, 1-7
Background and purpose Hypoxia negatively affects treatment outcome in both Human papillomavirus (HPV)-positive and -negative head and neck squamous cell carcinomas (HNSCC). Despite HPV-positive patients having a relatively good prognosis, hypoxic HP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efacad9b4bfb547b75e723a5d1c83b06
https://hdl.handle.net/2066/222052
https://hdl.handle.net/2066/222052
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 10954, p 10954 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 20
International Journal of Molecular Sciences
Volume 22
Issue 20
Androgen receptor (AR) is a ligand-mediated transcription factor that belongs to the superfamily of steroid receptors. AR is overexpressed in most glioblastomas and is a potential therapeutic target. In prostate and breast cancers, AR activation can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1080f31d0c67a422fa343d09473a68ca
https://www.zora.uzh.ch/id/eprint/209437/
https://www.zora.uzh.ch/id/eprint/209437/
Autor:
Dougall M. Norris, Kristen C. Cooke, James G. Burchfield, Daniel J. Fazakerley, Armella Zadoorian, Alison L Kearney, David E. James, James R. Krycer
Publikováno v:
J Biol Chem
The Ser/Thr protein kinase Akt regulates essential biological processes such as cell survival, growth, and metabolism. Upon growth factor stimulation, Akt is phosphorylated at Ser(474); however, how this phosphorylation contributes to Akt activation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b2e6cc74d81aff567581615527f7fc5
https://doi.org/10.1074/jbc.ra119.010036
https://doi.org/10.1074/jbc.ra119.010036
Autor:
Suneet Sandhu, O. Giles Best, Stephen P. Mulligan, Narjis Fatima, Richard I. Christopherson, Kyle Crassini, Yandong Shen
Publikováno v:
Leukemia & Lymphoma. 60:1632-1643
Several key pathways mediate signaling via the B-cell receptor, including the mitogen-activated protein kinase-ERK1/2 pathway. However, inhibition of MEK1/2, a key component of the MAPK-ERK1/2 signaling cascade, results in paradoxical activation of A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7ace7fbefaf9b177fc9c914a1d28bf9
https://doi.org/10.1080/10428194.2018.1542148
https://doi.org/10.1080/10428194.2018.1542148
Autor:
Wei Wang, Yifeng Cui, Hongrui Guo, Dehai Wu, Yao Liu, Ning Zhang, Lianxin Liu, Bo Zhang, Shuhang Liang, Mengyang Xin, Jiabei Wang, Xianying Li, Linmao Sun, Yufeng Liu, Shugeng Zhang, Huanran Zhou, Yiqi Wang, Kun Ma
Publikováno v:
Cancer research. 81(23)
As a member of the phospholipase family, phospholipase C beta 1 (PLCB1) is involved in phospholipid hydrolysis and is frequently upregulated in human cancer. However, little is known about the role of PLCB1 in cholangiocarcinoma (CCA). In this study,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b4d34cfaee8879ad6a1ed2d36b747d2
https://pubmed.ncbi.nlm.nih.gov/34580062
https://pubmed.ncbi.nlm.nih.gov/34580062