Zobrazeno 1 - 10
of 778
pro vyhledávání: '"Akt, Protein kinase B"'
Autor:
Digicaylioglu, Murat, Garden, Gwenn, Timberlake, Sonia, Fletcher, Lauren, Lipton, Stuart A., Ruoslahti, Erkki
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2004 Jun . 101(26), 9855-9860.
Externí odkaz:
https://www.jstor.org/stable/3372547
Autor:
Sami Gabbouj, Simo Ryhänen, Mikael Marttinen, Rebekka Wittrahm, Mari Takalo, Susanna Kemppainen, Henna Martiskainen, Heikki Tanila, Annakaisa Haapasalo, Mikko Hiltunen, Teemu Natunen
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Alzheimer’s disease (AD) and type 2 diabetes (T2D) are both diseases with increasing prevalence in aging populations. T2D, characterized by insulin resistance and defective insulin signaling, is a common co-morbidity and a risk factor for AD, incre
Externí odkaz:
https://doaj.org/article/15215aa0ee3d4acfb1f0bd56cde7b958
Autor:
Yanfei Cai, Jingyu Zhu, Yun Chen, Jian Jin, Xinling Zhao, Kan Li, Lei Xu, Huazhong Li, Gang Huang
Publikováno v:
Journal of Advanced Research
Journal of Advanced Research, Vol 36, Iss, Pp 1-13 (2022)
Journal of Advanced Research, Vol 36, Iss, Pp 1-13 (2022)
Graphical abstract
Highlights • Virtual screening based on machine learning with multiple proteins was developed. • Discovery of a novel PI3Kγ inhibitor integrating virtual screening and bio-assays. • JN-KI3 selective inhibit PI3Kγ enzym
Highlights • Virtual screening based on machine learning with multiple proteins was developed. • Discovery of a novel PI3Kγ inhibitor integrating virtual screening and bio-assays. • JN-KI3 selective inhibit PI3Kγ enzym
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cdbf7fb8f578b72a0c3242e69513c71
https://doi.org/10.1016/j.jare.2021.04.007
https://doi.org/10.1016/j.jare.2021.04.007
Autor:
Qilong Wang, Yanze Yang, Mei Du, Jinna Wei, Xianxian Zheng, Zhang Han, Erwei Liu, Xiumei Gao, Yuefei Wang, Patrick Kwabena Oduro
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 1, Pp 50-75 (2022)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
The cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) signaling exert essential regulatory function in microbial-and onco-immunology through the induction of cytokines, primarily type I interferons. Recently, the aberrant and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eaf60046ceb32698b7a7ea7c3674b44
http://www.sciencedirect.com/science/article/pii/S2211383521001775
http://www.sciencedirect.com/science/article/pii/S2211383521001775
Akademický článek
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Akademický článek
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Publikováno v:
Journal of Advanced Research
Graphical abstract
Introduction Neomenthol, a cyclic monoterpenoid, is a stereoisomer of menthol present in the essential oil of Mentha spp. It is used in food as a flavoring agent, in cosmetics and medicines because of its cooling effects. Howe
Introduction Neomenthol, a cyclic monoterpenoid, is a stereoisomer of menthol present in the essential oil of Mentha spp. It is used in food as a flavoring agent, in cosmetics and medicines because of its cooling effects. Howe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7618e7dc6e2d535e1930d5f8c2bf7d7e
https://doi.org/10.1016/j.jare.2021.06.003
https://doi.org/10.1016/j.jare.2021.06.003
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 4, Pp 429-438 (2021)
Neoplasia (New York, N.Y.)
Neoplasia (New York, N.Y.)
Triple negative breast cancer (TNBC) is an aggressive disease with a 5-y relative survival rate of 11% after distant metastasis. To survive the metastatic cascade, tumor cells remodel their signaling pathways by regulating energy production and upreg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f579366bddfd960dbbe114706d860b9
http://www.sciencedirect.com/science/article/pii/S1476558621000154
http://www.sciencedirect.com/science/article/pii/S1476558621000154
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 3, Pp 750-762 (2021)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
The protein tyrosine phosphatase Src homology phosphotyrosyl phosphatase 2 (SHP2) is implicated in various cancers, and targeting SHP2 has become a promising therapeutic approach. We herein described a robust cross-validation high-throughput screenin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::114cd1e4de1acb4de79002f71ffaa0be
https://doi.org/10.1016/j.apsb.2020.10.021
https://doi.org/10.1016/j.apsb.2020.10.021
Autor:
Shanshan Zhang, Antonio Cigliano, Xianqiong Liu, Xinhua Song, Jie Zhang, Pan Wang, Yong Zeng, Xin Chen, Matthias Evert, Haichuan Wang, Ke Liu, Diego F. Calvisi, Jingxiao Wang, Hong Wu, Jiaoyuan Jia, Silvia Ribback, Li Che
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and molecular gastroenterology and hepatology, vol 11, iss 4
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 4, Pp 1095-1117 (2021)
Cellular and molecular gastroenterology and hepatology, vol 11, iss 4
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 4, Pp 1095-1117 (2021)
Background & Aims Yes-associated protein (YAP) and its paralog transcriptional co-activator with post synaptic density protein, drosophila disc large tumor suppressor and zonula occludens-1-binding motif (TAZ) are 2 co-activators downstream of Hippo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::447d7bcd8df00ed9b5b307b5d9e85371
https://doi.org/10.1016/j.jcmgh.2020.11.008
https://doi.org/10.1016/j.jcmgh.2020.11.008