New Adamantane-Containing Edaravone Conjugates as Potential Neuroprotective Agents for ALS Treatments.

Autor: Lapshina MA; Institute of Physiologically Active Compounds at the Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, 1 Severnij proezd, 142432 Chernogolovka, Russia., Shevtsova EF; Institute of Physiologically Active Compounds at the Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, 1 Severnij proezd, 142432 Chernogolovka, Russia., Grigoriev VV; Institute of Physiologically Active Compounds at the Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, 1 Severnij proezd, 142432 Chernogolovka, Russia., Aksinenko AY; Institute of Physiologically Active Compounds at the Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, 1 Severnij proezd, 142432 Chernogolovka, Russia., Ustyugov AA; Institute of Physiologically Active Compounds at the Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, 1 Severnij proezd, 142432 Chernogolovka, Russia., Steinberg DA; Institute of Physiologically Active Compounds at the Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, 1 Severnij proezd, 142432 Chernogolovka, Russia., Maleev GV; Institute of Physiologically Active Compounds at the Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, 1 Severnij proezd, 142432 Chernogolovka, Russia., Dubrovskaya ES; Institute of Physiologically Active Compounds at the Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, 1 Severnij proezd, 142432 Chernogolovka, Russia., Goreva TV; Institute of Physiologically Active Compounds at the Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, 1 Severnij proezd, 142432 Chernogolovka, Russia., Epishina TA; Institute of Physiologically Active Compounds at the Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, 1 Severnij proezd, 142432 Chernogolovka, Russia., Zamoyski VL; Institute of Physiologically Active Compounds at the Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, 1 Severnij proezd, 142432 Chernogolovka, Russia., Makhaeva GF; Institute of Physiologically Active Compounds at the Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, 1 Severnij proezd, 142432 Chernogolovka, Russia., Fisenko VP; Department of Pharmacology, Sechenov I. M. First Moscow State Medical University, 8 Build. 2 Trubetskaya Str., 119991 Moscow, Russia., Veselov IM; Institute of Physiologically Active Compounds at the Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, 1 Severnij proezd, 142432 Chernogolovka, Russia., Vinogradova DV; Institute of Physiologically Active Compounds at the Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, 1 Severnij proezd, 142432 Chernogolovka, Russia., Bachurin SO; Institute of Physiologically Active Compounds at the Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, 1 Severnij proezd, 142432 Chernogolovka, Russia.

Publikováno v: Molecules (Basel, Switzerland) [Molecules] 2023 Nov 13; Vol. 28 (22). Date of Electronic Publication: 2023 Nov 13.

Conjugates of Methylene Blue with Cycloalkaneindoles as New Multifunctional Agents for Potential Treatment of Neurodegenerative Disease.

Autor: Bachurin SO; Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, 142432 Chernogolovka, Russia., Shevtsova EF; Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, 142432 Chernogolovka, Russia., Makhaeva GF; Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, 142432 Chernogolovka, Russia., Aksinenko AY; Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, 142432 Chernogolovka, Russia., Grigoriev VV; Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, 142432 Chernogolovka, Russia., Goreva TV; Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, 142432 Chernogolovka, Russia., Epishina TA; Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, 142432 Chernogolovka, Russia., Kovaleva NV; Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, 142432 Chernogolovka, Russia., Boltneva NP; Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, 142432 Chernogolovka, Russia., Lushchekina SV; Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, 119334 Moscow, Russia., Rudakova EV; Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, 142432 Chernogolovka, Russia., Vinogradova DV; Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, 142432 Chernogolovka, Russia., Shevtsov PN; Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, 142432 Chernogolovka, Russia., Pushkareva EA; Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, 142432 Chernogolovka, Russia., Dubova LG; Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, 142432 Chernogolovka, Russia., Serkova TP; Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, 142432 Chernogolovka, Russia., Veselov IM; Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, 142432 Chernogolovka, Russia., Fisenko VP; Department of Pharmacology, Institute of Biodesign and Complex System Modelling, Biomedical Science & Technology Park, Sechenov I.M. First Moscow State Medical University, 119991 Moscow, Russia., Richardson RJ; Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2022 Nov 11; Vol. 23 (22). Date of Electronic Publication: 2022 Nov 11.

Modulation of Calcium-Activated Chloride Currents in Rat Neurons with New 2-Aminotiophene-3-Carboxylic Acid Derivatives.

Autor: Zamoyski VL; Institute of Physiologically Active Compounds, Russian Academy of Sciences, Chernogolovka, Moscow oblast, Russia. vzam@yandex.ru., Grigoriev VV; Institute of Physiologically Active Compounds, Russian Academy of Sciences, Chernogolovka, Moscow oblast, Russia., Aksinenko AY; Institute of Physiologically Active Compounds, Russian Academy of Sciences, Chernogolovka, Moscow oblast, Russia., Bachurin SO; Institute of Physiologically Active Compounds, Russian Academy of Sciences, Chernogolovka, Moscow oblast, Russia.

Publikováno v: Doklady. Biochemistry and biophysics [Dokl Biochem Biophys] 2020 Sep; Vol. 494 (1), pp. 222-226. Date of Electronic Publication: 2020 Oct 20.

Novel conjugates of aminoadamantanes with carbazole derivatives as potential multitarget agents for AD treatment.

Autor: Bachurin SO; Institute of Physiologically Active Compounds Russian Academy of Sciences, Chernogolovka, 142432, Russia., Shevtsova EF; Institute of Physiologically Active Compounds Russian Academy of Sciences, Chernogolovka, 142432, Russia., Makhaeva GF; Institute of Physiologically Active Compounds Russian Academy of Sciences, Chernogolovka, 142432, Russia., Grigoriev VV; Institute of Physiologically Active Compounds Russian Academy of Sciences, Chernogolovka, 142432, Russia., Boltneva NP; Institute of Physiologically Active Compounds Russian Academy of Sciences, Chernogolovka, 142432, Russia., Kovaleva NV; Institute of Physiologically Active Compounds Russian Academy of Sciences, Chernogolovka, 142432, Russia., Lushchekina SV; Institute of Physiologically Active Compounds Russian Academy of Sciences, Chernogolovka, 142432, Russia.; Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, 119334, Russia., Shevtsov PN; Institute of Physiologically Active Compounds Russian Academy of Sciences, Chernogolovka, 142432, Russia., Neganova ME; Institute of Physiologically Active Compounds Russian Academy of Sciences, Chernogolovka, 142432, Russia., Redkozubova OM; Institute of Physiologically Active Compounds Russian Academy of Sciences, Chernogolovka, 142432, Russia., Bovina EV; Institute of Physiologically Active Compounds Russian Academy of Sciences, Chernogolovka, 142432, Russia., Gabrelyan AV; Institute of Physiologically Active Compounds Russian Academy of Sciences, Chernogolovka, 142432, Russia., Fisenko VP; Department of Pharmacology, Therapeutic Faculty, I. M. Setchenov Moscow Medical Academy, ul. Bol'shaya Pirogovskaya 2/6, Moscow, 119881 Russia., Sokolov VB; Institute of Physiologically Active Compounds Russian Academy of Sciences, Chernogolovka, 142432, Russia., Aksinenko AY; Institute of Physiologically Active Compounds Russian Academy of Sciences, Chernogolovka, 142432, Russia., Echeverria V; Universidad San Sebastián, General Cruz 1577, Concepción, Chile., Barreto GE; Departamento de Nutrición y Bioquímica, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogotá D.C., Colombia.; Instituto de Ciencias Biomédicas, Universidad Autónoma de Chile, Santiago, Chile., Aliev G; Institute of Physiologically Active Compounds Russian Academy of Sciences, Chernogolovka, 142432, Russia.; GALLY International Biomedical Research Consulting LLC., San Antonio, TX 78229, USA.; School of Health Science and Healthcare Administration, University of Atlanta, Johns Creek, GA 30097, USA.

Publikováno v: Scientific reports [Sci Rep] 2017 Mar 30; Vol. 7, pp. 45627. Date of Electronic Publication: 2017 Mar 30.

Psychotropic Activity of New Fluorinated Derivatives of Tetrahydrocarbasoles.

Autor: Nikolaeva NS; Institute of Physiologically Active Substances, Russian Academy of Sciences, Chernogolovka, Moscow Region, Russia. nikolaevans@bk.ru., Sokolov VB; Institute of Physiologically Active Substances, Russian Academy of Sciences, Chernogolovka, Moscow Region, Russia., Aksinenko AY; Institute of Physiologically Active Substances, Russian Academy of Sciences, Chernogolovka, Moscow Region, Russia., Ovchinnikov RK; Institute of Physiologically Active Substances, Russian Academy of Sciences, Chernogolovka, Moscow Region, Russia., Bachurin SO; Institute of Physiologically Active Substances, Russian Academy of Sciences, Chernogolovka, Moscow Region, Russia., Kinzirskii AS; Institute of Physiologically Active Substances, Russian Academy of Sciences, Chernogolovka, Moscow Region, Russia.

Publikováno v: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2016 Feb; Vol. 160 (4), pp. 455-8. Date of Electronic Publication: 2016 Feb 23.