Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Akshyaya Rath"'
Autor:
Suresh R. Giri, Bibhuti Bhoi, Chitrang Trivedi, Akshyaya Rath, Rohan Rathod, Anish Sharma, Ramchandra Ranvir, Shekhar Kadam, Kailash Ingale, Hiren Patel, Abraham Nyska, Mukul R. Jain
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-13 (2023)
Abstract Background Saroglitazar is a novel PPAR-α/γ agonist with predominant PPAR-α activity. In various preclinical models, saroglitazar has been shown to prevent & reverse symptoms of NASH. In view of these observations, and the fact that NASH
Externí odkaz:
https://doaj.org/article/20294723c6a8452ea710ad36979e2b91
Autor:
Akshyaya Rath, Baban Thube, Shailesh R. Shah, Suresh Pola, Harilal Patel, Hoshang Patel, Pandurang Zaware, Jeevan Kumar, Harikishore Pingali, Mukul R. Jain, S.R. Sundar, Pankaj Makadia, Jitendra Patel, Suresh Giri, Debdutta Bandyopadhyay, Ramchandra Ranvir
Publikováno v:
Bioorganic & Medicinal Chemistry. 35:116071
The ever-growing prevalence of Type-2 diabetes in the world has an urgent need for multiple orally effective agents that can regulate glucose homeostasis. G-Protein coupled receptor 119 (GPR 119) agonists have demonstrated the glucose-dependent insul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::072c8cd4e0ffd09af118806aee19811d
https://doi.org/10.1016/j.bmc.2021.116071
https://doi.org/10.1016/j.bmc.2021.116071
Autor:
Rashmi Ramdhave, Rohan Manubhai. Rathod, Mukul R. Jain, Akshyaya Rath, Bibhuti Bhoi, Chitrang Trivedi, Rajesh Sundar, Brijesh Kumar Srivastava, Ranjit C. Desai, Gautam D Patel, Debdutta Bandyopadhyay, Suresh Giri
Publikováno v:
Diabetes. 67
GPR40 is a G-protein-coupled receptor predominantly expressed in pancreatic β-cells. Agonists of GPR40 are known to stimulate insulin secretion and reduces circulating glucose levels in a glucose-dependent manner. TAK-875, a GPR40 small molecule ago
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::161480e510f5deddde98f14d793f37e4
https://doi.org/10.2337/db18-1194-p
https://doi.org/10.2337/db18-1194-p
Autor:
Akshyaya Rath, Chitrang Trivedi, Bibhuti Bhoi, Suresh Giri, Mukul R. Jain, Rohan Manubhai. Rathod
Publikováno v:
Diabetes. 67
Saroglitazar is a novel dual PPARα/γ agonist that shows significant triglyceride-lowering and insulin-sensitizing effects in animal models and humans. Saroglitazar causes insulin sensitization and increases flux of lipids in adipocytes thereby prev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1297e9b733e89b549f5b40933d4de667
https://doi.org/10.2337/db18-1203-p
https://doi.org/10.2337/db18-1203-p
Autor:
Akshyaya Rath, Hiren Patel, Sib Sankar Roy, Rohan Manubhai. Rathod, Suresh Giri, Bibhuti Bhoi, Ramchandra Ranvir, Shekhar Kadam, Chitrang Trivedi, Eshani Karmakar, Pankaj R. Patel, Walter Wahli, Prabodha Swain, Mukul R. Jain, Nabanita Das
Publikováno v:
Liver international : official journal of the International Association for the Study of the Liver. 38(6)
Background & Aims: Non‐alcoholic fatty liver disease (NAFLD) and non‐alcoholic steatohepatitis (NASH) are common clinico‐pathological conditions that affect millions of patients worldwide. In this study, the efficacy of saroglitazar, a novel PP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ceeec68bd119b9d6b4df86997b926d3
https://pubmed.ncbi.nlm.nih.gov/29164820
https://pubmed.ncbi.nlm.nih.gov/29164820
Autor:
Vishal B. Unadkat, Kalapatapu V.V.M. Sairam, Jignesh K. Joshi, Vrajesh Pandya, Nirav Joshi, Hiteshkumar Soni, Harilal Patel, Haresh Ajani, Pankaj R. Patel, Bhavesh Sharma, Ganes Chakrabarti, Jigar S. Patel, Jeevan Kumar, Tushar Jarag, Balaji Chaugule, Akshyaya Rath, Mukul R. Jain, Bhavesh Parmar
Publikováno v:
European Journal of Medicinal Chemistry. 58:136-152
A novel series of potent and efficacious factor Xa inhibitors which possesses sulfoximine moiety as novel S4 binding element in anthranilamide chemotype has been identified. Lead optimization at this novel P4 group led to many potent factor Xa inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c56d4fe8f15287f7d9f01b7d6254273
https://doi.org/10.1016/j.ejmech.2012.10.005
https://doi.org/10.1016/j.ejmech.2012.10.005
Publikováno v:
Vascular Pharmacology. 53:68-76
Although the cardioprotective role of carbon monoxide (CO) has been studied against myocardial ischemia-reperfusion (I/R) injury, the role of coronary endothelium and underlying mechanism in carbon monoxide-induced cardioprotection is not well unders
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb644d06d6092b629d9d541be0b9f3d5
https://doi.org/10.1016/j.vph.2010.04.002
https://doi.org/10.1016/j.vph.2010.04.002
Autor:
Chitrang Trivedi, Ramchandra Ranvir, Bibhuti Bhoi, Pankaj R. Patel, Geeta Vanage, Suresh Giri, Purvi Vyas, Mukul R. Jain, Akshyaya Rath
Publikováno v:
Pharmacology Research & Perspectives
Saroglitazar is a novel nonthiazolidinediones (TZD) and nonfibric acid derivative designed to act as dual regulator of lipids and glucose metabolism by activating peroxisome proliferator-activated receptors (PPAR). These studies evaluate the efficacy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2da793b0c257a94736afa60933987ec
https://doi.org/10.1002/prp2.136
https://doi.org/10.1002/prp2.136
Autor:
Akshyaya Rath, Vrajesh Pandya, Mukul R. Jain, Hiteshkumar Soni, Ganes Chakrabarti, Mehul Raviya, Bhavesh Parmar, Pankaj R. Patel, Mubeen Shaikh, Jigar S. Patel, Balaji Chaugule, Nirav Joshi, Harilal Patel, Kalapatapu V.V.M. Sairam, Jignesh K. Joshi
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(19)
Two novel series of 5-nitro-2-phenoxybenzoic acid derivatives are designed as potent PAI-1 inhibitors using hybridization and conformational restriction strategy in the tiplaxtinin and piperazine chemo types. The lead compounds 5a, 6c, and 6e exhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7535e6857ea5295fd430e83c3d3d9840
https://pubmed.ncbi.nlm.nih.gov/21880486
https://pubmed.ncbi.nlm.nih.gov/21880486
Autor:
Akshyaya Rath, Harshkant D. Trivedi, Mukul R. Jain, Hiteshkumar Soni, Praful P. Patel, Savan Patel, Aviseka Acharya
Publikováno v:
Indian Journal of Pharmacology
Objectives: The aim was to investigate the nephroprotective effect of combination of aliskiren (ASK), a direct renin inhibitor and pentoxifylline (PTX), inhibitor of tumor necrotic factor-alpha (TNF-alpha), in rat remnant kidney model of chronic kidn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afa1ced66a24a2b0c24f4094d9dd80e8
https://doi.org/10.4103/0253-7613.150351
https://doi.org/10.4103/0253-7613.150351