Výsledky vyhledávání - "Akshaya K. Meher"

Akademický článek

BAFF neutralization impairs the autoantibody-mediated clearance of dead adipocytes and aggravates obesity-induced insulin resistance

Autor: Melissa D. Lempicki, Jake A. Gray, Gabriel Abuna, Ramiro M. Murata, Senad Divanovic, Coleen A. McNamara, Akshaya K. Meher

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

B cell-activating factor (BAFF) is a critical TNF-family cytokine that regulates homeostasis and peripheral tolerance of B2 cells. BAFF overproduction promotes autoantibody generation and autoimmune diseases. During obesity, BAFF is predominantly pro

Externí odkaz: https://doaj.org/article/35503957c9b04965b4f3a57a5a6b6011

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Akademický článek

Adaptive thermogenesis in brown adipose tissue involves activation of pannexin-1 channels

Publikováno v: Molecular Metabolism, Vol 44, Iss , Pp 101130- (2021)

Objective: Brown adipose tissue (BAT) is specialized in thermogenesis. The conversion of energy into heat in brown adipocytes proceeds via stimulation of β-adrenergic receptor (βAR)-dependent signaling and activation of mitochondrial uncoupling pro

Externí odkaz: https://doaj.org/article/3bac5da2881d485a8632564ecf041a48

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Akademický článek

Macrophages sensing oxidized DAMPs reprogram their metabolism to support redox homeostasis and inflammation through a TLR2-Syk-ceramide dependent mechanism

Autor: Vlad Serbulea, Clint M. Upchurch, Katelyn W. Ahern, Gael Bories, Paxton Voigt, Dory E. DeWeese, Akshaya K. Meher, Thurl E. Harris, Norbert Leitinger

Publikováno v: Molecular Metabolism, Vol 7, Iss , Pp 23-34 (2018)

Objective: Macrophages control tissue homeostasis and inflammation by sensing and responding to environmental cues. However, the metabolic adaptation of macrophages to oxidative tissue damage and its translation into inflammatory mechanisms remains e

Externí odkaz: https://doaj.org/article/a70635b001c540ebbfabf86f68213458

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Akademický článek

GSK-3β Can Regulate the Sensitivity of MIA-PaCa-2 Pancreatic and MCF-7 Breast Cancer Cells to Chemotherapeutic Drugs, Targeted Therapeutics and Nutraceuticals

Autor: Stephen L. Abrams, Shaw M. Akula, Akshaya K. Meher, Linda S. Steelman, Agnieszka Gizak, Przemysław Duda, Dariusz Rakus, Alberto M. Martelli, Stefano Ratti, Lucio Cocco, Giuseppe Montalto, Melchiorre Cervello, Peter Ruvolo, Massimo Libra, Luca Falzone, Saverio Candido, James A. McCubrey

Publikováno v: Cells, Vol 10, Iss 4, p 816 (2021)

Glycogen synthase kinase-3 (GSK-3) is a regulator of signaling pathways. KRas is frequently mutated in pancreatic cancers. The growth of certain pancreatic cancers is KRas-dependent and can be suppressed by GSK-3 inhibitors, documenting a link betwee

Externí odkaz: https://doaj.org/article/40c21af23bd74ea8a11c56b197a2955e

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Akademický článek

Pannexin 1 is required for full activation of insulin-stimulated glucose uptake in adipocytes

Autor: Samantha E. Adamson, Akshaya K. Meher, Yu-hsin Chiu, Joanna K. Sandilos, Nathaniel P. Oberholtzer, Natalie N. Walker, Stefan R. Hargett, Scott A. Seaman, Shayn M. Peirce-Cottler, Brant E. Isakson, Coleen A. McNamara, Susanna R. Keller, Thurl E. Harris, Douglas A. Bayliss, Norbert Leitinger

Publikováno v: Molecular Metabolism, Vol 4, Iss 9, Pp 610-618 (2015)

Objective: Defective glucose uptake in adipocytes leads to impaired metabolic homeostasis and insulin resistance, hallmarks of type 2 diabetes. Extracellular ATP-derived nucleotides and nucleosides are important regulators of adipocyte function, but

Externí odkaz: https://doaj.org/article/9b68597c47644aa7ac673be018d95003

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B Cell–Activating Factor Antagonism Attenuates the Growth of Experimental Abdominal Aortic Aneurysm

Autor: Prasad Srikakulapu, Gorav Ailawadi, Matthew J. Johnsrude, Akshaya K. Meher, Gilbert R. Upchurch, Michael Spinosa, Melissa Lempicki, Coleen A. McNamara, Norbert Leitinger, William G. Montgomery

Publikováno v: Am J Pathol

B cell–activating factor (BAFF), part of a tumor necrosis factor family of cytokines, was recently identified as a regulator of atherosclerosis; however, its role in aortic aneurysm has not been determined. Here, the study examined the effect of se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2db3c8eaf42f1e08393091f917909bf
https://doi.org/10.1016/j.ajpath.2021.08.012

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Abstract P142: B Cell Activating Factor Neutralization In High-Fat Diet-Induced Obese Mice Retains Adipose Tissue B Cells And Exacerbates Glucose Homeostasis

Autor: Melissa D Lempicki, Jake Gray, Saikat Paul, Debajit Bhowmick, Akshaya K Meher

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 41

Adults with type 2 diabetes have a two-to-three-fold increased risk of cardiovascular diseases. B cell activating factor (BAFF), a tumor necrosis superfamily member, is implicated both in diabetes and cardiovascular diseases. BAFF deficiency in mice

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a85186cc9d82e2d15d150ae308ad10c7
https://doi.org/10.1161/atvb.41.suppl_1.p142

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Resolvin D1 decreases abdominal aortic aneurysm formation by inhibiting NETosis in a mouse model

Autor: Gorav Ailawadi, Michael Spinosa, Guanyi Lu, J. Michael Cullen, Michael S. Conte, Akshaya K. Meher, William G. Montgomery, Robert B. Hawkins, Anna Z. Fashandi, Ashish Sharma, Gang Su, Gilbert R. Upchurch, Morgan Salmon

Publikováno v: Journal of Vascular Surgery. 68:93S-103S

Objective Resolvins have been shown to attenuate inflammation, whereas NETosis, the process of neutrophils releasing neutrophil extracellular traps (NETs), produces increased inflammation. It is hypothesized that treatment of animals with resolvin D1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5a4c7757e3e00931b7d42a0ed7d1177
https://doi.org/10.1016/j.jvs.2018.05.253

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