Zobrazeno 1 - 10 of 11 pro vyhledávání: '"Akshay R. Kamath"'
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Posttranscriptional Regulation of PARG mRNA by HuR Facilitates DNA Repair and Resistance to PARP Inhibitors
Autor: John M. Pascal, Charles J. Yeo, Saswati N. Chand, Eric Londin, Akshay R. Kamath, Nicole Meisner-Kober, Karen E. Knudsen, Jordan M. Winter, Michael J. Pishvaian, Joseph A. Cozzitorto, Jonathan R. Brody, Shruti Lal, Matthew J. Schiewer, Laura Scolaro, Carmella Romeo, Avinoam Nevler, Wei Jiang, Mahsa Zarei
Publikováno v: Cancer Research. 77:5011-5025
The majority of pancreatic ductal adenocarcinomas (PDAC) rely on the mRNA stability factor HuR (ELAV-L1) to drive cancer growth and progression. Here, we show that CRISPR-Cas9–mediated silencing of the HuR locus increases the relative sensitivity o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f065ac43c6f57fdc506dfc98245be382
https://doi.org/10.1158/0008-5472.can-16-2704
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8
Posttranscriptional Regulation of
Autor: Saswati N, Chand, Mahsa, Zarei, Matthew J, Schiewer, Akshay R, Kamath, Carmella, Romeo, Shruti, Lal, Joseph A, Cozzitorto, Avinoam, Nevler, Laura, Scolaro, Eric, Londin, Wei, Jiang, Nicole, Meisner-Kober, Michael J, Pishvaian, Karen E, Knudsen, Charles J, Yeo, John M, Pascal, Jordan M, Winter, Jonathan R, Brody
Publikováno v: Cancer research. 77(18)
The majority of pancreatic ductal adenocarcinomas (PDA) rely on the mRNA stability factor HuR (ELAV-L1) to drive cancer growth and progression. Here we show that CRISPR-Cas9-mediated silencing of the HuR locus increases the relative sensitivity of PD
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::020067f21f3a784c9fea7cbea56b293f
https://pubmed.ncbi.nlm.nih.gov/28687616
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10
Abstract 1995: HuR dependent inhibition of PARG enhances PARP inhibitor therapy for DNA repair proficient and deficient pancreatic cancer cells
Autor: Eric Londin, Jordan M. Winter, Karen E. Knudsen, Carmella Romeo, Joseph A. Cozzitorto, Mahsa Zarei, Charles J. Yeo, Jonathan R. Brody, Isidore Rigoutsos, Akshay R. Kamath, Saswati N. Chand, Matthew J. Schiewer, Nicole Meisner-Kober, John M. Pascal
Publikováno v: Cancer Research. 76:1995-1995
Introduction: Despite our deep understanding of genetic drivers of the disease, pancreatic ductal adenocarcinoma (PDA) continues to be associated with dismal survival rates. Targeting the DNA repair machinery has emerged as a promising therapeutic st
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::719b0af49a78e96099166634c9d97ca4
https://doi.org/10.1158/1538-7445.am2016-1995
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Plný text Recenzováno Digitální knihovna AV ČR
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