Zobrazeno 1 - 10
of 177
pro vyhledávání: '"Akshay K. Vaishnaw"'
Autor:
Aimee M. Deaton, Aditi Dubey, Lucas D. Ward, Peter Dornbos, Jason Flannick, AMP-T2D-GENES Consortium, Elaine Yee, Simina Ticau, Leila Noetzli, Margaret M. Parker, Rachel A. Hoffing, Carissa Willis, Mollie E. Plekan, Aaron M. Holleman, Gregory Hinkle, Kevin Fitzgerald, Akshay K. Vaishnaw, Paul Nioi
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Abdominal fat has been shown to increase cardiometabolic disease risk. In this study, the authors report that loss-of-function variants in the gene INHBE associate with lower BMI-adjusted waist-to-hip ratio, a surrogate measure of abdominal fat.
Externí odkaz:
https://doaj.org/article/a18ddbd876414e068f4e4d4e72abd720
Autor:
Margaret M. Parker, Scott M. Damrauer, Catherine Tcheandjieu, David Erbe, Emre Aldinc, Philip N. Hawkins, Julian D. Gillmore, Leland E. Hull, Julie A. Lynch, Jacob Joseph, Simina Ticau, Alexander O. Flynn-Carroll, Aimee M. Deaton, Lucas D. Ward, Themistocles L. Assimes, Philip S. Tsao, Kyong-Mi Chang, Daniel J. Rader, Kevin Fitzgerald, Akshay K. Vaishnaw, Gregory Hinkle, Paul Nioi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Hereditary transthyretin-mediated (hATTR) amyloidosis is an underdiagnosed, progressively debilitating disease caused by mutations in the transthyretin (TTR) gene. V122I, a common pathogenic TTR mutation, is found in 3–4% of individuals of
Externí odkaz:
https://doaj.org/article/5c5a6c2a17f74f718458b7ee194eb2f4
Autor:
Howard A. Burris, Jared A. Gollob, Dinah W.Y. Sah, Akshay K. Vaishnaw, Christina Gamba-Vitalo, Saraswathy V. Nochur, Jeffrey Cehelsky, Valerie A. Clausen, Renta M. Hutabarat, Nenad Svrzikapa, Gregory Hinkle, Rachel E. Meyers, David Bumcrot, Iva Toudjarska, Amy C. Seila White, Jamie Harrop, Rick Falzone, Mrinal M. Gounder, Maria Alsina, Jeffrey R. Infante, Daniel C. Cho, Luis Paz-Ares, Glen J. Weiss, Gary K. Schwartz, Andres Cervantes, Patricia M. LoRusso, Geoffrey I. Shapiro, Josep Tabernero
Supplementary Figures PDF file - 114K, Includes sequence information on KSP and VEGF siRNAs, murine Hep3B tumor model data with ALN-VSP, ALN-VSP Phase I study design, KSP and VEGF mRNA levels in tumor cell lines and normal liver, and comparison of AL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::798921fa41c39c58506772199a018c15
https://doi.org/10.1158/2159-8290.22530521
https://doi.org/10.1158/2159-8290.22530521
Autor:
Howard A. Burris, Jared A. Gollob, Dinah W.Y. Sah, Akshay K. Vaishnaw, Christina Gamba-Vitalo, Saraswathy V. Nochur, Jeffrey Cehelsky, Valerie A. Clausen, Renta M. Hutabarat, Nenad Svrzikapa, Gregory Hinkle, Rachel E. Meyers, David Bumcrot, Iva Toudjarska, Amy C. Seila White, Jamie Harrop, Rick Falzone, Mrinal M. Gounder, Maria Alsina, Jeffrey R. Infante, Daniel C. Cho, Luis Paz-Ares, Glen J. Weiss, Gary K. Schwartz, Andres Cervantes, Patricia M. LoRusso, Geoffrey I. Shapiro, Josep Tabernero
Supplementary Methods and Legends PDF file - 72K, Includes detailed methods for 5' RACE assay and DCE-MRI scans, as well as figure legends for the six supplementary figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b60fded2d3b851bda5dc56f8308997f4
https://doi.org/10.1158/2159-8290.22530518
https://doi.org/10.1158/2159-8290.22530518
Autor:
Howard A. Burris, Jared A. Gollob, Dinah W.Y. Sah, Akshay K. Vaishnaw, Christina Gamba-Vitalo, Saraswathy V. Nochur, Jeffrey Cehelsky, Valerie A. Clausen, Renta M. Hutabarat, Nenad Svrzikapa, Gregory Hinkle, Rachel E. Meyers, David Bumcrot, Iva Toudjarska, Amy C. Seila White, Jamie Harrop, Rick Falzone, Mrinal M. Gounder, Maria Alsina, Jeffrey R. Infante, Daniel C. Cho, Luis Paz-Ares, Glen J. Weiss, Gary K. Schwartz, Andres Cervantes, Patricia M. LoRusso, Geoffrey I. Shapiro, Josep Tabernero
Supplementary Tables PDF file - 67K, Includes data showing effect of ALN-VSP on spleen in non-human primates, tumor response data from the Phase I trial, and safety data (including adverse events and dose-limiting toxicities) from the Phase I trial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2abf232c1a30a2513228f151bdf1bb65
https://doi.org/10.1158/2159-8290.22530515
https://doi.org/10.1158/2159-8290.22530515
Autor:
Daniel P. Judge, Arnt V. Kristen, Martha Grogan, Mathew S. Maurer, Rodney H. Falk, Mazen Hanna, Julian Gillmore, Pushkal Garg, Akshay K. Vaishnaw, Jamie Harrop, Christine Powell, Verena Karsten, Xiaoping Zhang, Marianne T. Sweetser, John Vest, Philip N. Hawkins
Publikováno v:
Cardiovascular Drugs and Therapy
Cardiovasc Drugs Ther
Cardiovasc Drugs Ther
Purpose The Phase 3 ENDEAVOUR study evaluated revusiran, an investigational RNA interference therapeutic targeting hepatic transthyretin (TTR) production, for treating cardiomyopathy caused by hereditary transthyretin-mediated (hATTR) amyloidosis. Me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45887ee13b195341e5d70adae8db7d93
http://europepmc.org/articles/PMC7242280
http://europepmc.org/articles/PMC7242280
Autor:
Aimee M, Deaton, Aditi, Dubey, Lucas D, Ward, Peter, Dornbos, Jason, Flannick, Elaine, Yee, Simina, Ticau, Leila, Noetzli, Margaret M, Parker, Rachel A, Hoffing, Carissa, Willis, Mollie E, Plekan, Aaron M, Holleman, Gregory, Hinkle, Kevin, Fitzgerald, Akshay K, Vaishnaw, Paul, Nioi
Publikováno v:
Nature communications. 13(1)
Identifying genetic variants associated with lower waist-to-hip ratio can reveal new therapeutic targets for abdominal obesity. We use exome sequences from 362,679 individuals to identify genes associated with waist-to-hip ratio adjusted for BMI (WHR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b85c6a64a90f4c3fe87d875cca8d13a3
https://pubmed.ncbi.nlm.nih.gov/35896531
https://pubmed.ncbi.nlm.nih.gov/35896531
Publikováno v:
Fair Disclosure Wire (Quarterly Earnings Reports). 09/13/2022.
Autor:
Margaret M. Parker, Scott M. Damrauer, Catherine Tcheandjieu, David Erbe, Emre Aldinc, Philip N. Hawkins, Julian Gillmore, Leland E. Hull, Julie A. Lynch, Jacob Joseph, Simina Ticau, Alexander O. Flynn-Carroll, Aimee M. Deaton, Lucas D. Ward, Themistocles L. Assimes, Philip S. Tsao, Kyong-Mi Chang, Daniel J. Rader, Kevin Fitzgerald, Akshay K. Vaishnaw, Gregory Hinkle, Paul Nioi
Publikováno v:
Journal of Cardiac Failure. 26:S96
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1146a161dee4b9ae8c365953fb0995f3
https://doi.org/10.1016/j.cardfail.2020.09.281
https://doi.org/10.1016/j.cardfail.2020.09.281
Publikováno v:
Fair Disclosure Wire (Quarterly Earnings Reports). 03/15/2023.