Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Akshay K. Ahuja"'
Autor:
Akshay K. Ahuja, Karolina Jodkowska, Federico Teloni, Anna H. Bizard, Ralph Zellweger, Raquel Herrador, Sagrario Ortega, Ian D. Hickson, Matthias Altmeyer, Juan Mendez, Massimo Lopes
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
In fast proliferating embryonic stem cells (ESC) the DNA damage response is activated by mechanisms that are as yet elusive. Here, Ahuja et al.link the DNA damage response to replication stress in mouse ESCs, caused by a short G1 phase, and propose f
Externí odkaz:
https://doaj.org/article/fc4914771f1340c399684df4e94a8bca
Publikováno v:
Molecular and cellular biology
Poly(ADP-ribosyl)ation (PAR) has been implicated in various aspects of the cellular response to DNA damage and genome stability. Although 17 human poly(ADP-ribose) polymerase (PARP) genes have been identified, a single poly(ADP-ribosyl) glycohydrolas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::338b379efa1870594a5c1eef09751caa
https://doi.org/10.1128/mcb.01077-14
https://doi.org/10.1128/mcb.01077-14
Autor:
Panagiotis Galanos, Spiros D. Garbis, Paul A. Townsend, Igor B. Roninson, Antonis Kokkalis, Begoña Canovas, Akshay K. Ahuja, Alexander Polyzos, Dimitris Kletsas, Jiri Bartek, Apolinar Maya-Mendoza, Vassilis G. Gorgoulis, Konstantinos Vougas, Sofia Havaki, Fani-Marlen Roumelioti, Ralph Zellweger, Ana Igea, Angel R. Nebreda, Massimo Lopes, Emanuel Kanavakis, Dimitris Thanos, David Walter, Claus Storgaard Sørensen, Maria Tzetis, Sarantis Gagos, J. Julian Blow, Emma J. Haagensen
Publikováno v:
Dipòsit Digital de la UB
Universidad de Barcelona
Galanos, P, Vougas, K, Walter, D, Polyzos, A, Haagensen, E J, Kokkalis, A, Roumelioti, F-M, Gagos, S, Tzetis, M, Canovas, B, Igea, A, Ahuja, A K, Zellweger, R, Havaki, S, Kanavakis, E, Kletsas, D, Roninson, I B, Garbis, S D, Lopes, M, Nebreda, A, Thanos, D, Blow, J J, Townsend, P, Sørensen, C S, Bartek, J & Gorgoulis, V G 2016, ' Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing ', Nature Cell Biology, vol. 18, no. 7, pp. 777-789 . https://doi.org/10.1038/ncb3378
Recercat. Dipósit de la Recerca de Catalunya
instname
Universidad de Barcelona
Galanos, P, Vougas, K, Walter, D, Polyzos, A, Haagensen, E J, Kokkalis, A, Roumelioti, F-M, Gagos, S, Tzetis, M, Canovas, B, Igea, A, Ahuja, A K, Zellweger, R, Havaki, S, Kanavakis, E, Kletsas, D, Roninson, I B, Garbis, S D, Lopes, M, Nebreda, A, Thanos, D, Blow, J J, Townsend, P, Sørensen, C S, Bartek, J & Gorgoulis, V G 2016, ' Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing ', Nature Cell Biology, vol. 18, no. 7, pp. 777-789 . https://doi.org/10.1038/ncb3378
Recercat. Dipósit de la Recerca de Catalunya
instname
The cyclin-dependent kinase inhibitor p21(WAF1/Cip1) is the prototype downstream effector of the tumor suppressor protein p53. Yet, evidence from human cancer and mice models, imply that p21(WAF1/Cip1), under certain conditions, can exercise oncogeni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83b274528551c3d0e53290489b5c84ad
https://doi.org/10.5167/uzh-125175
https://doi.org/10.5167/uzh-125175
Autor:
Wolf-Dietrich Hardt, Chakradhar Yakkala, Annika Hausmann, Akshay K. Ahuja, Kristin Fritsch, Markus G. Manz, Yasuyuki Saito, Larisa V. Kovtonyuk, Alvaro Gomariz, César Nombela-Arrieta, Kurt Jacobs, Massimo Lopes, Hitoshi Takizawa
Publikováno v:
Cell stem cell. 21(2)
Bacterial infection leads to consumption of short-lived innate immune effector cells, which then need to be replenished from hematopoietic stem and progenitor cells (HSPCs). HSPCs express pattern recognition receptors, such as Toll-like receptors (TL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::021179c1012a1005cb6faccd8e873147
https://pubmed.ncbi.nlm.nih.gov/32619512
https://pubmed.ncbi.nlm.nih.gov/32619512
Autor:
Julien Dairou, Akshay K. Ahuja, Mounira Amor-Guéret, Géraldine Buhagiar-Labarchède, Denis Biard, Sarah Lambert, Simon Gemble, Massimo Lopes, Rosine Onclercq-Delic
Publikováno v:
PLoS Genetics
PLoS Genetics, Public Library of Science, 2015, 11 (7), pp.e1005384. ⟨10.1371/journal.pgen.1005384⟩
PLoS genetics
PLoS Genetics, 2015, 11 (7), pp.e1005384. ⟨10.1371/journal.pgen.1005384⟩
PLoS Genetics, Vol 11, Iss 7, p e1005384 (2015)
PLoS Genetics, Public Library of Science, 2015, 11 (7), pp.e1005384. ⟨10.1371/journal.pgen.1005384⟩
PLoS genetics
PLoS Genetics, 2015, 11 (7), pp.e1005384. ⟨10.1371/journal.pgen.1005384⟩
PLoS Genetics, Vol 11, Iss 7, p e1005384 (2015)
Genome stability is jeopardized by imbalances of the dNTP pool; such imbalances affect the rate of fork progression. For example, cytidine deaminase (CDA) deficiency leads to an excess of dCTP, slowing the replication fork. We describe here a novel m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36bb4047e5cfc1b46d50ac888a71e140
https://doi.org/10.5167/uzh-112527
https://doi.org/10.5167/uzh-112527
Autor:
Akshay K. Ahuja, David J. Brenner, Robert J. Hardwick, Yuri E. Dubrova, Michael M. Weil, Ruth C. Barber, Paula C. Genik
Publikováno v:
Mutagenesis. 23(5)
Using single-molecule polymerase chain reaction, the frequency of spontaneous and radiation-induced mutation at an expanded simple tandem repeat (ESTR) locus was studied in DNA samples extracted from sperm and bone marrow of Atm knockout (Atm(+/-)) h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22e535629b265d96c75e54e76f7660eb
https://pubmed.ncbi.nlm.nih.gov/18499649
https://pubmed.ncbi.nlm.nih.gov/18499649
Autor:
Ralph Zellweger, Matthias Altmeyer, Karolina Jodkowska, Federico Teloni, Akshay K. Ahuja, Ian D. Hickson, Raquel Herrador, Massimo Lopes, Juan Méndez, Sagrario Ortega, Anna H. Bizard
Publikováno v:
Nature communications
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Nature Communications
Ahuja, A K, Jodkowska, K, Teloni, F, Bizard, A H, Zellweger, R, Herrador, R, Ortega, S, Hickson, I D, Altmeyer, M, Mendez, J & Lopes, M 2016, ' A short G1 phase imposes constitutive replication stress and fork remodelling in mouse embryonic stem cells ', Nature Communications, vol. 7, 10660 . https://doi.org/10.1038/ncomms10660
Repisalud
Instituto de Salud Carlos III (ISCIII)
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Nature Communications
Ahuja, A K, Jodkowska, K, Teloni, F, Bizard, A H, Zellweger, R, Herrador, R, Ortega, S, Hickson, I D, Altmeyer, M, Mendez, J & Lopes, M 2016, ' A short G1 phase imposes constitutive replication stress and fork remodelling in mouse embryonic stem cells ', Nature Communications, vol. 7, 10660 . https://doi.org/10.1038/ncomms10660
Repisalud
Instituto de Salud Carlos III (ISCIII)
Embryonic stem cells (ESCs) represent a transient biological state, where pluripotency is coupled with fast proliferation. ESCs display a constitutively active DNA damage response (DDR), but its molecular determinants have remained elusive. Here we s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e4fe56cd3bd5e1b7333d5f155df0af0