Výsledky vyhledávání - "Akram N. Saab"

Effect of Aminomethyl (N-Mannich Base) Derivatization on the Ability of S6Acetyloxymethyl-S-Mercaptopurine Prodrug to Deliver 6-Mercaptopurine through Hairless Mouse Skin

Autor: René Villanueva, Akram N. Saab, Howard D. Beall, Kenneth B. Sloan

Publikováno v: Journal of Pharmaceutical Sciences. 79:1099-1104

A series of 9-aminomethyl-S6-acetyloxymethyl-6-mercaptopurine (9-AM-6-AOM-6-MP) prodrugs have been synthesized and characterized, and their ability to deliver total 6-mercaptopurine (6-MP) through hairless mouse skin has been measured. The 9-AM-6-AOM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::936cdab727e1711c78a5aa993d5fa6f5
https://doi.org/10.1002/jps.2600791212

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Synthesis and mechanisms of decomposition of some cephalosporin prodrugs

Autor: Anwar A. Hussain, Akram N. Saab, Lewis W. Dittert, Indravadan H. Patel

Publikováno v: Journal of Pharmaceutical Sciences. 79:802-805

The delta‐3 and delta‐2 methyl esters of cefazolin were synthesized. The kinetics and mechanisms of degradation of the methyl esters and the delta‐3 and delta‐2 isomers of pivaloyloxymethyl prodrug esters of the new cephalosporin ceftetrame (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0894d760c4e54b3f0d1991d7a8e7d068
https://doi.org/10.1002/jps.2600790912

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The effect of aminomethyl (N-Mannich base) derivatization on the ability of S6-pivaloyloxymethyl-6-mercaptopurine prodrug to deliver 6-mercaptopurine through hairless mouse skin

Autor: Akram N. Saab, Kenneth B. Sloan

Publikováno v: International Journal of Pharmaceutics. 57:253-261

A series of aminomethyl (N-Mannich base) derivatives of S6-pivaloyloxymethyl-6-mercaptopurine (6-POM-6-MP) have been synthesized from the reaction of 6-POM-6-MP with formaldehyde and secondary amines. In contrast to the results from the aminomethylat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::57ad6ce119e3d7cdbf4808078ef76d2b
https://doi.org/10.1016/0378-5173(89)90215-9

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Hydroxymethylation and aminomethylation of 6-mercaptopurine and its derivatives

Autor: Akram N. Saab, Robert P. Waranis, Kenneth B. Sloan, Kevin G. Siver

Publikováno v: Journal of Heterocyclic Chemistry. 25:1077-1081

Labile aminomethyl and hydroxymethyl derivatives of 6-mercaptopurine (I) (6-MP) and S6-acyloxymethyl-6-MP have been converted to stable acetyloxymethyl derivatives by their reaction with acetic anhydride. Analysis of the reaction products and compari

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::23d2eae07156a4d3fdfe4dade17fb204
https://doi.org/10.1002/jhet.5570250406

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Isomerization of cephalosporin esters: implications for the prodrug ester approach to enhancing the oral bioavailabilities of cephalosporins

Autor: Akram N. Saab, Lewis W. Dittert, Anwar A. Hussain

Publikováno v: Journal of pharmaceutical sciences. 77(10)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7e92e0522a8603a074cd96c269b840a
https://pubmed.ncbi.nlm.nih.gov/3236237

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ChemInform Abstract: Hydroxymethylation and Aminomethylation of 6-Mercaptopurine and Its Derivatives

Autor: Akram N. Saab, Kenneth B. Sloan, Robert P. Waranis, Kevin G. Siver

Publikováno v: ChemInform. 20

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4fbef953f30a9ecee48787ecf7fdb125
https://doi.org/10.1002/chin.198911203

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