Safety and long-term immunogenicity of the two-dose heterologous Ad26.ZEBOV and MVA-BN-Filo Ebola vaccine regimen in adults in Sierra Leone: a combined open-label, non-randomised stage 1, and a randomised, double-blind, controlled stage 2 trial

Autor: Kargbo, M, Bockarie, E, James, N L, Kabbah, A, Kamara, A, Koroma, K H, Langley, S O, William, N, Kessebeh, R, Mooney, T, Conteh, L, Smout, E, Allieu, K, Bangura, K, Bangura, M S, Bangura, M A, Jalloh, H, Jalloh, A B, Kamara, I, Kamara, M, Konteh, A, Koroma, S, Marrah, C, Sesay, M, Sesay, M T, Deen, A T, Jalloh, A, Kaimbay, R M, Kain, D, Kamara, E L, Kamara, M P, Kamara, O J, Kamara, S L M, Kanneh, M, Koroma, A H, Lahai, D, Mansaray, I S, Marah, W S, Massaquoi, M J, Nabie, A, Saidu, N S, Samai, I, Tengheh, J N, Turay, A S, Fornah, A, Sesay, F, Sow, A, Swaray, E, Mansaray, F, Ade-Cole, T, Bangura, L M, Conteh, M L, Koroma, A M, Koroma, M, Sam, A, Scott, T, Sessie, T, Sunders, J-H C, Turay, S I-S, Weekes, J, Sheku, M, Gibson, L, Kowuor, D, Ahamed, I, Allieu, W, Kabba, D U, Kamara, F J, Kebbie, M S, Pessima, M, Wurie, A, Bah, F, Bangura, A I, Bangura, R A S, Blango, L, Boima, S, Conteh, M, Conteh, Y, Daramy, M L, Fofanah, O, George, E, Hanson, T F, Jalloh, M I, Kalawa, M, Kamara, A M, Kamara, F E, Kamara, G M, Kamara, H M, Kamara, P B D, Kamara, R T, Kamara, R, Kanneh, D P, Komeh, I, Kuyateh, M, Mansaray, F F, Mansaray, M M, Sillah, A B, Tarawally, M A, Turya, O S, Yawmah, J B, Leigh, B, Watson-Jones, D, Greenwood, B, Samai, M H, Deen, G F, Marke, D, Piot, P, Smith, P, Edmunds, J, Lees, S, Larson, H, Weiss, H, Wilson, P, Maxwell, C, Ishola, D, Afolabi, M, Baiden, F, Akoo, P, Owusu-Kyei, K, Tindanbil, D, Bower, H, Stuart, J, Bah, O M, Rogers, B T, Serry-Bangura, A, Swaray, I B, Bangura, A, David, I J, Davies, D G M, Kallon, J A, Kamara, A B, Kamara, I F, Kamara, M M, Morovia, F E, Suma, F B, Thompson, F, Murray, M, Sesay, I, Kakay, O, Suma, F, Foster, J, Philips, R, Manno, D, Gallager, K, Cox, S, Howard, N, Cesay, M, Torrani, P, Sharma, S, Snowden, E, Banks, T, Harber, T, Brown, J, Howard, K, Melton, N, Malcolm, S, Welsh, S, Eggo, R, Jendrossek, M, Pearson, C, Van Hoof, J, Douoguih, M, Offergelt, K, Robinson, C, Keshinro, B, Van Alst, M, Mahajan, N, Bockstal, V, Goldstein, N, Gaddah, A, Heerwegh, D, Luhn, K, Leyssen, M, Lowe, B, Awuondo, K, Hafezi, H, Hancox, E, Kohn, B, Tuda, G O, Koroma, F, Bangura, G, Kroma, M T, Fofanah, L, Pessima, A, Rogers, M, Sheriff, O, Ajala, T W, Fangawa, J, Foday Jr, S, Jabbie, I, Mansaray, B, Mansaray, H A, Sesay, K, Charles, M K, Heroe, P C, Karbo, M L, Yansaneh, IS, Egoeh, S G, Trye, A, Amponsah, M, Alghali, N D, Bah, A, Bangura, IJ, Cole, A C, Fofanah, K, Fofanah, S, Jalloh, H U, Jalloh, K F N, Jalloh, N, Kabba, H U, Kabba, J N, Kabba, M, Kamara, J S, Kanjie, F, Kanu, A P, Kargbo, I, Kassa-Koroma, G, Koroma, S B, Sankoh, A, Sankoh, T, Sesay, O D, Wilhem, H, Williams, C T, Bangura, I, Ben-Rogers, Y, Jamboria, F J, Kamara, N, Kanawah, I, Kargbo, A T, Swaray, I, Amara, L, Bundu, I, Jakema, H B, Kamara, K, Sheku, M F, Adeleye, Q, Akhigbe, I, Bakalemwa, R, Chami, N P, Sylvester, T, Altmann, L, Kamara, B, van Roey, K, Conteh, P, Samura, M, Gandie, V, Marrah, M, Moinina, E, Kalokoh, J, Bangura, M I, Bosompem, S, Hilton, T, Jusu, M O, Borboh, P, Brima, A S, Caulker, A F Y, Kallon, A, Koroma, B, Macauley, RC, Saquee, T M D, Williams, H I, Bangura, A R, Fornah, J, Idriss, B, Sillah, M, Mackay, W, Aleghen, B, Murray, T, Edem-Hotah, J, Fatorma, T, Amara, F, Bangura, S, Bonnie, E, Sannoh, M, Donaldson, A, Ndingi, S, Nyaberi, D, Pereira, M, Rothwell, A, Vy, V, Nyallay, L, Fombah, A, Saidu, S, Connor, N, Dambo, T P, Fakaba, P J, Fatorma, M M E, Johnson, C L, Kogba, D B, Lahai, A, Vincent, W, Yambasu, N, Bangura, M, Tengbeh, A, Kabia, R, Nyakoi, AM, Callaghan, M, Enria, L, Lee, S, Ishola, David, Manno, Daniela ^*, Afolabi, Muhammed O, Keshinro, Babajide, Bockstal, Viki, Rogers, Baimba, Owusu-Kyei, Kwabena, Serry-Bangura, Alimamy, Swaray, Ibrahim, Lowe, Brett, Kowuor, Dickens, Baiden, Frank, Mooney, Thomas, Smout, Elizabeth, Köhn, Brian, Otieno, Godfrey T, Jusu, Morrison, Foster, Julie, Samai, Mohamed, Deen, Gibrilla Fadlu, Larson, Heidi, Lees, Shelley, Goldstein, Neil, Gallagher, Katherine E, Gaddah, Auguste, Heerwegh, Dirk, Callendret, Benoit, Luhn, Kerstin, Robinson, Cynthia, Leyssen, Maarten, Greenwood, Brian, Douoguih, Macaya, Leigh, Bailah, Watson-Jones, Deborah

Publikováno v: In The Lancet Infectious Diseases January 2022 22(1):97-109

Nurses Navigating Mental Health During Uncharted Times: Self, Others, Systems (S.O.S)!

Autor: Akoo, Chaman, Price, Sheri, McMillan, Kimberly, Ingraham, Kenchera, Ayoub, Abby, Rolle Sands, Shamel, Shankland, Mylène, Bourgeault, Ivy

Publikováno v: Canadian journal of nursing research; December 2024, Vol. 56 Issue: 4 p396-405, 10p

Safety profile of the RTS,S/AS01 malaria vaccine in infants and children: additional data from a phase III randomized controlled trial in sub-Saharan Africa

Autor: Yolanda Guerra Mendoza, Elodie Garric, Amanda Leach, Marc Lievens, Opokua Ofori-Anyinam, Jean-Yves Pirçon, Jens-Ulrich Stegmann, Pascale Vandoolaeghe, Lucas Otieno, Walter Otieno, Seth Owusu-Agyei, Jahit Sacarlal, Nahya Salim Masoud, Hermann Sorgho, Marcel Tanner, Halidou Tinto, Innocent Valea, Ali Takadir Mtoro, Patricia Njuguna, Martina Oneko, Godfrey Allan Otieno, Kephas Otieno, Samwel Gesase, Mary J Hamel, Irving Hoffman, Seyram Kaali, Portia Kamthunzi, Peter Kremsner, Miguel Lanaspa, Bertrand Lell, John Lusingu, Anangisye Malabeja, Pedro Aide, Pauline Akoo, Daniel Ansong, Kwaku Poku Asante, James A Berkley, Samuel Adjei, Tsiri Agbenyega, Selidji Todagbe Agnandji, Lode Schuerman

Publikováno v: Human Vaccines & Immunotherapeutics, Vol 15, Iss 10, Pp 2386-2398 (2019)

A phase III, double-blind, randomized, controlled trial (NCT00866619) in sub-Saharan Africa showed RTS,S/AS01 vaccine efficacy against malaria. We now present in-depth safety results from this study. 8922 children (enrolled at 5–17 months) and 6537

Externí odkaz: https://doaj.org/article/32543b5d892e42548e7e71deabcf0cf8

Immunogenicity and Vaccine Shedding After 1 or 2 Doses of rVSVΔG-ZEBOV-GP Ebola Vaccine (ERVEBO®): Results From a Phase 2, Randomized, Placebo-controlled Trial in Children and Adults.

Autor: Lee AW; Merck & Co., Inc., Rahway, New Jersey, USA., Liu K; Merck & Co., Inc., Rahway, New Jersey, USA., Lhomme E; Inserm, CHU Bordeaux, CIC 1401, EUCLID/F-CRIN Clinical Trials Platform, University of Bordeaux, Bordeaux, France., Blie J; Partnership for Research on Ebola Vaccines in Liberia (PREVAIL), Monrovia, Liberia., McCullough J; Advanced BioMedical Laboratories (ABML), Cinnaminson, New Jersey, USA., Onorato MT; Merck & Co., Inc., Rahway, New Jersey, USA., Connor L; Merck & Co., Inc., Rahway, New Jersey, USA., Simon JK; Merck & Co., Inc., Rahway, New Jersey, USA., Dubey S; Merck & Co., Inc., Rahway, New Jersey, USA., VanRheenen S; Merck & Co., Inc., Rahway, New Jersey, USA., Deutsch J; Merck & Co., Inc., Rahway, New Jersey, USA., Owens A; Merck & Co., Inc., Rahway, New Jersey, USA., Morgan A; Merck & Co., Inc., Rahway, New Jersey, USA., Welebob C; Merck & Co., Inc., Rahway, New Jersey, USA., Hyatt D; Merck & Co., Inc., Rahway, New Jersey, USA., Nair S; Merck & Co., Inc., Rahway, New Jersey, USA., Hamzé B; Pôle Recherche Clinique, Institut National de la Santé et de la Recherche Médicale (Inserm), Paris, France., Guindo O; University Clinical Research Center (UCRC), Bamako, Mali., Sow SO; CVD-Mali, Bamako, Mali., Beavogui AH; Centre National de Formation et de Recherche en Santé Rurale (CNFRSR), Maferinyah, Guinea., Leigh B; College of Medicine & Allied Health Sciences (COMAHS), University of Sierra Leone, Freetown, Sierra Leone., Samai M; College of Medicine & Allied Health Sciences (COMAHS), University of Sierra Leone, Freetown, Sierra Leone., Akoo P; Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine (LSHTM), London, United Kingdom., Serry-Bangura A; College of Medicine & Allied Health Sciences (COMAHS), University of Sierra Leone, Freetown, Sierra Leone., Fleck S; Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine (LSHTM), London, United Kingdom., Secka F; Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine (LSHTM), London, United Kingdom., Lowe B; Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine (LSHTM), London, United Kingdom., Watson-Jones D; Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine (LSHTM), London, United Kingdom.; Mwanza Intervention Trials Unit, National Institute for Medical Research, Mwanza, Tanzania., Roy C; Inserm, CHU Bordeaux, CIC 1401, EUCLID/F-CRIN Clinical Trials Platform, University of Bordeaux, Bordeaux, France.; University of Bordeaux, INSERM, MART, UMS 54, F-33000 Bordeaux, France., Hensley LE; National Bio and Agro-Defense Facility (NBAF), United States Department of Agriculture (USDA), Manhattan, Kansas, USA., Kieh M; Partnership for Research on Ebola Vaccines in Liberia (PREVAIL), Monrovia, Liberia., Coller BG; Merck & Co., Inc., Rahway, New Jersey, USA.

Publikováno v: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2024 Apr 10; Vol. 78 (4), pp. 870-879.

Research on Emerging Infections Offers an Opportunity for Public Health Intelligence on Non-Communicable Diseases: Hypertension Prevalence in Volunteers for an Ebola Vaccine Trial in Northern Sierra Leone

Autor: Dickens Kowuor, David Ishola, Muhammed Afolabi, Frank Baiden, Kwabena Owusu-Kyei, Baimba Rogers, Osman Bah, Ibrahim Swaray, Joseph Edem-Hotah, Gibrilla Fadlu Deen, Daniela Manno, Philip Ayieko, Julie Foster, Pauline Akoo, Daniel Tindanbil, Mohamed Samai, Brian Greenwood, Bailah Leigh, Deborah Watson-Jones

Publikováno v: Proceedings, Vol 45, Iss 1, p 11 (2020)

Introduction: The West African Ebola outbreak of 2014–2016 necessitated clinical trials in communities with limited health data. The EBOVAC-Salone Ebola vaccine trial is ongoing in the largely rural Kambia District in northern Sierra Leone. To gain

Externí odkaz: https://doaj.org/article/114f8a7014e84c98bf3705e4accd0d7e