Výsledky vyhledávání - "Akm Khyrul, Wara"

Perivascular Fibrosis Is Mediated by a KLF10-IL-9 Signaling Axis in CD4+ T Cells

Autor: Rulin Zhuang, Jingshu Chen, Henry S. Cheng, Carmel Assa, Anurag Jamaiyar, Arvind K. Pandey, Daniel Pérez-Cremades, Bofang Zhang, Aspasia Tzani, Akm Khyrul Wara, Jorge Plutzky, Victor Barrera, Preetida Bhetariya, Richard N. Mitchell, Zhongmin Liu, Mark W. Feinberg

Publikováno v: Circ Res

Background: Perivascular fibrosis, characterized by increased amount of connective tissue around vessels, is a hallmark for vascular disease. Ang II (angiotensin II) contributes to vascular disease and end-organ damage via promoting T-cell activation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5a2421f60fd8527c0339e2ae80fe448
https://europepmc.org/articles/PMC9149118/

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KLF10 deficiency in CD4

Autor: Akm Khyrul, Wara, Shruti, Rawal, Xilan, Yang, Daniel, Pérez-Cremades, Madhur, Sachan, Jingshu, Chen, Mark W, Feinberg

Publikováno v: Atherosclerosis. 359

Accumulating evidence supports a critical role for CD4Here, we investigated a cell-autonomous role of a transcription factor, Krüppel-like factor 10 (KLF10), in CD4Taken together, these findings establish a critical role for KLF10 in regulating CD4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::054465359726b893b3b21d9a4f0095c1
https://pubmed.ncbi.nlm.nih.gov/36174463

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KLF10 Deficiency in CD4

Autor: Akm Khyrul, Wara, Shijia, Wang, Chun, Wu, Fang, Fang, Stefan, Haemmig, Brittany N, Weber, Ceren O, Aydogan, Yevgenia, Tesmenitsky, Hassan, Aliakbarian, John R, Hawse, Malayannan, Subramaniam, Lei, Zhao, Peter T, Sage, Ali, Tavakkoli, Amanda, Garza, Lydia, Lynch, Alexander S, Banks, Mark W, Feinberg

Publikováno v: Cell reports

SUMMARY CD4+ T cells regulate inflammation and metabolism in obesity. An imbalance of CD4+ T regulatory cells (Tregs) is critical in the development of insulin resistance and diabetes. Although cytokine control of this process is well understood, tra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0b1f6cde659315b2a30c2d8a4f21a4f9
https://pubmed.ncbi.nlm.nih.gov/33378664

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KLF10 Deficiency in CD4+ T Cells Triggers Obesity, Insulin Resistance, and Fatty Liver

Autor: Stefan Haemmig, Mark W. Feinberg, Alexander S. Banks, Ceren O. Aydogan, Lei Zhao, Chun Wu, Shijia Wang, Fang Fang, Lydia Lynch, Malayannan Subramaniam, Amanda E Garza, Hassan Aliakbarian, John R. Hawse, Peter T. Sage, Akm Khyrul Wara, Ali Tavakkoli, Yevgenia Tesmenitsky, Brittany Weber

Publikováno v: Cell Reports. 33:108550

CD4(+) T cells regulate inflammation and metabolism in obesity. An imbalance of CD4(+) T regulatory cells (Tregs) is critical in the development of insulin resistance and diabetes. Although cytokine control of this process is well understood, transcr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b952ed4dbc563ab31ec6fd1de62e6a0c
https://doi.org/10.1016/j.celrep.2020.108550

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MicroRNA‐181b inhibits thrombin‐mediated endothelial activation and arterial thrombosis by targeting caspase recruitment domain family member 10

Autor: Xinghui Sun, Grégory Franck, Stefan Haemmig, Yihuan Deng, Mark W. Feinberg, Jibin Lin, Shaolin He, Dafeng Yang, Basak Icli, Dazhu Li, Akm Khyrul Wara

Publikováno v: The FASEB Journal. 30:3216-3226

Thrombogenic and inflammatory mediators, such as thrombin, induce NF-κB–mediated endothelial cell (EC) activation and dysfunction, which contribute to pathogenesis of arterial thrombosis. The role of anti-inflammatory microRNA-181b (miR-181b) on t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8371cb997c5e2a8f4f06ce5d0d51eb97
https://doi.org/10.1096/fj.201500163r

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MicroRNA-26a Regulates Pathological and Physiological Angiogenesis by Targeting BMP/SMAD1 Signaling

Autor: Javid Moslehi, Eva Plovie, Andrew Schissler, Calum A. MacRae, Ronglih Liao, Jianru Shi, Robert F. Padera, Meghan Cahill, Srilatha Raghuram, Julio Flávio Meirelles Marchini, Akm Khyrul Wara, Xinghui Sun, Kevin Croce, Zoltan Arany, Basak Icli, Hui-Wen Cheng, Mark W. Feinberg

Publikováno v: Circulation Research. 113:1231-1241

Rationale : The rapid induction and orchestration of new blood vessels are critical for tissue repair in response to injury, such as myocardial infarction, and for physiological angiogenic responses, such as embryonic development and exercise. Object

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98c9a8fe8c99d0f9c9207509387b5538
https://doi.org/10.1161/circresaha.113.301780

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Bone Marrow–Derived Kruppel-Like Factor 10 Controls Reendothelialization in Response to Arterial Injury

Autor: Yevgenia Tesmenitsky, Basak Icli, Mark W. Feinberg, Andre Manica, Xinghui Sun, Kevin Croce, Julio Flávio Meirelles Marchini, Akm Khyrul Wara

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 33:1552-1560

Objective— The objective of this study was to investigate the role of Kruppel-like factor (KLF) 10, a zinc-finger transcription factor, in bone marrow (BM)–derived cell responses to arterial endothelial injury. Accumulating evidence indicates tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f5d8b4a49e794de274816922b25be51
https://doi.org/10.1161/atvbaha.112.300655

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Regulation of impaired angiogenesis in diabetic dermal wound healing by microRNA-26a

Autor: Denizhan Ozdemir, Mark W. Feinberg, Akm Khyrul Wara, Basak Icli, Giorgio Giatsidis, Christoph S. Nabzdyk, Michael E. Auster, Jorge Lujan-Hernandez, Meghan Cahill, Xinghui Sun, Dennis P. Orgill

Wound healing is a physiological reparative response to injury and a well-orchestrated process that involves hemostasis, cellular migration, proliferation, angiogenesis, extracellular matrix deposition, and wound contraction and re-epithelialization.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33a5548c882754e6002d571b617c343d
https://europepmc.org/articles/PMC4764471/

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MicroRNA-181b Improves Glucose Homeostasis and Insulin Sensitivity by Regulating Endothelial Function in White Adipose Tissue

Autor: Mark W. Feinberg, Naomi M. Hamburg, Basak Icli, Sona Kang, Yu Zhang, Dazhu Li, Akm Khyrul Wara, Jibin Lin, Xinghui Sun, Nathan Belkin

Rationale: The pathogenesis of insulin resistance involves dysregulated gene expression and function in multiple cell types, including endothelial cells (ECs). Post-transcriptional mechanisms such as microRNA-mediated regulation of gene expression co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b22459aa3cb313388a80905d0e69785f
https://europepmc.org/articles/PMC4779381/

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