Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Akke Botma"'
Autor:
Jennifer Ose, Akke Botma, Yesilda Balavarca, Katharina Buck, Dominique Scherer, Nina Habermann, Jolantha Beyerle, Katrin Pfütze, Petra Seibold, Elisabeth J. Kap, Axel Benner, Lina Jansen, Katja Butterbach, Michael Hoffmeister, Hermann Brenner, Alexis Ulrich, Martin Schneider, Jenny Chang‐Claude, Barbara Burwinkel, Cornelia M. Ulrich
Publikováno v:
Cancer Medicine, Vol 7, Iss 7, Pp 2797-2807 (2018)
Abstract Folate‐mediated one‐carbon metabolism (FOCM) is a key pathway essential for nucleotide synthesis, DNA methylation, and repair. This pathway is a critical target for 5‐fluorouracil (5‐FU), which is predominantly used for colorectal ca
Externí odkaz:
https://doaj.org/article/baca2d28fd69426b8dac49badda0a572
Autor:
Dominique Scherer, Heike Deutelmoser, Yesilda Balavarca, Reka Toth, Nina Habermann, Katharina Buck, Elisabeth Johanna Kap, Akke Botma, Petra Seibold, Lina Jansen, Justo Lorenzo Bermejo, Korbinian Weigl, Axel Benner, Michael Hoffmeister, Alexis Ulrich, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Cornelia M. Ulrich
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 15, p 5395 (2020)
An individual’s inherited genetic variation may contribute to the ‘angiogenic switch’, which is essential for blood supply and tumor growth of microscopic and macroscopic tumors. Polymorphisms in angiogenesis-related genes potentially predispos
Externí odkaz:
https://doaj.org/article/ae198368a95f431db3ae7c84336e4bfc
Autor:
Renate C. Heine-Bröring, Renate M. Winkels, Akke Botma, Fränzel J. B. van Duijnhoven, Audrey Y. Jung, Jan H. Kleibeuker, Fokko M. Nagengast, Hans F. A. Vasen, Ellen Kampman
Publikováno v:
PLoS ONE, Vol 9, Iss 1 (2014)
Externí odkaz:
https://doaj.org/article/ba3fc8385e984f31b6285788e8b99dc3
Autor:
Renate C Heine-Bröring, Renate M Winkels, Akke Botma, Fränzel J B van Duijnhoven, Audrey Y Jung, Jan H Kleibeuker, Fokko M Nagengast, Hans F A Vasen, Ellen Kampman
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e66819 (2013)
Individuals with Lynch syndrome have a high lifetime risk of developing colorectal tumors. In this prospective cohort study of individuals with Lynch syndrome, we examined associations between use of dietary supplements and occurrence of colorectal a
Externí odkaz:
https://doaj.org/article/adf4f1a25d1d4743b5b17dffdc12c3a7
Autor:
Cornelia M. Ulrich, Johanna W. Lampe, John D. Potter, Karel D. Klika, Odilia Popanda, Christoph Weigel, Reka Toth, Nina Habermann, Akke Botma, David B. Liesenfeld
Supplementary Materials and Methods. Supplementary Figure 1: Study design of the ABC intervention study. Supplementary Figure 2: Intracellular concentrations of free salicylate in aspirin treated colorectal cancer cell lines expressed as nmol per tot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00eb4f1cf3044dfe3e96a96a8e400dfc
https://doi.org/10.1158/1055-9965.22437900
https://doi.org/10.1158/1055-9965.22437900
Autor:
Carsten Herskind, Jenny Chang-Claude, Frederik Wenz, Sabine Behrens, Anne Kirchner, Nicole Gürth, Frank A. Giordano, Elena Sperk, Irmgard Helmbold, Akke Botma, Petra Seibold, Marlon R. Veldwijk
Purpose:Radiation-induced lymphocyte apoptosis (RILA) has been suggested as a predictive assay for adverse late reactions after radiotherapy. Thus, low RILA values of T-lymphocyte subpopulations have been associated with increased risk for various en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83c09cd4fb0b8d6f97d82775acaf34d0
https://doi.org/10.1158/1078-0432.c.6529239.v1
https://doi.org/10.1158/1078-0432.c.6529239.v1
Autor:
Cornelia M. Ulrich, Johanna W. Lampe, John D. Potter, Karel D. Klika, Odilia Popanda, Christoph Weigel, Reka Toth, Nina Habermann, Akke Botma, David B. Liesenfeld
Background: Aspirin use is an effective strategy for the chemoprevention of colorectal cancer, even at low doses. However, in order to implement aspirin interventions, risk–benefit balances and biologic mechanisms need to be better defined; to furt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f82dd5d92fa09860002766d09f8490f
https://doi.org/10.1158/1055-9965.c.6516111.v1
https://doi.org/10.1158/1055-9965.c.6516111.v1
Autor:
Carsten Herskind, Jenny Chang-Claude, Frederik Wenz, Sabine Behrens, Anne Kirchner, Nicole Gürth, Frank A. Giordano, Elena Sperk, Irmgard Helmbold, Akke Botma, Petra Seibold, Marlon R. Veldwijk
Supplementary Tables and Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::213161c0f09b7b162c16fa26308c9116
https://doi.org/10.1158/1078-0432.22475970.v1
https://doi.org/10.1158/1078-0432.22475970.v1
Autor:
Elena Sperk, Akke Botma, Petra Seibold, Sabine Behrens, Nicole Gürth, Frank A. Giordano, Frederik Wenz, Jenny Chang-Claude, Marlon R. Veldwijk, Irmgard Helmbold, Anne-Katrin Kirchner, Carsten Herskind
Publikováno v:
Clinical Cancer Research. 25:562-572
Purpose: Radiation-induced lymphocyte apoptosis (RILA) has been suggested as a predictive assay for adverse late reactions after radiotherapy. Thus, low RILA values of T-lymphocyte subpopulations have been associated with increased risk for various e
Autor:
Elisabeth J. Kap, Jenny Chang-Claude, Michael Hoffmeister, Nina Habermann, Katja Butterbach, Katrin Pfütze, Alexis Ulrich, Jolantha Beyerle, Yesilda Balavarca, Barbara Burwinkel, Jennifer Ose, Akke Botma, Martin Schneider, Katharina Buck, Petra Seibold, Lina Jansen, Cornelia M. Ulrich, Dominique Scherer, Hermann Brenner, Axel Benner
Publikováno v:
Cancer Medicine
Cancer Medicine, Vol 7, Iss 7, Pp 2797-2807 (2018)
Cancer Medicine, Vol 7, Iss 7, Pp 2797-2807 (2018)
Folate‐mediated one‐carbon metabolism (FOCM) is a key pathway essential for nucleotide synthesis, DNA methylation, and repair. This pathway is a critical target for 5‐fluorouracil (5‐FU), which is predominantly used for colorectal cancer (CRC