Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Akiyoshi TANI"'
Autor:
Atsushi Kumanogoh, Hisashi Wada, Yoshito Takeda, Mari Tone, Yasushi Shintani, Kota Iwahori, Michinari Hirata, Azumi Ueyama, Akiyoshi Tani, Jun-Ichi Haruta
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 4 (2024)
Background Cancer immunotherapy including immune checkpoint inhibitors is only effective for a limited population of patients with cancer. Therefore, the development of novel cancer immunotherapy is anticipated. In preliminary studies, we demonstrate
Externí odkaz:
https://doaj.org/article/c59908baeae14bb5b96141a34ab1d949
Autor:
Hsin-Pei Weng, Chiao-Hsu Ke, Chun-Wei Tung, Akiyoshi Tani, Chia-Chi Wang, Wen-Yuan Yang, Yu-Shan Wang, Winston Han, Chi-Hsun Liao, Hirotaka Tomiyasu, Chen-Si Lin
Publikováno v:
Cancer Cell International, Vol 23, Iss 1, Pp 1-22 (2023)
Abstract Background Tumor-derived extracellular vesicles (EVs) have been proposed as the essential mediator between host immunity and cancer development. These EVs conduct cellular communication to facilitate tumor growth, enable invasion and metasta
Externí odkaz:
https://doaj.org/article/25558b396a7f4dce8cfe5d511c7a8803
Autor:
Hajime Asada, Akiyoshi Tani, Hiroki Sakuma, Miyuki Hirabayashi, Yuki Matsumoto, Kei Watanabe, Masaya Tsuboi, Shino Yoshida, Kei Harada, Takao Uchikai, Yuko Goto-Koshino, James K. Chambers, Genki Ishihara, Tetsuya Kobayashi, Mitsuhiro Irie, Kazuyuki Uchida, Koichi Ohno, Makoto Bonkobara, Hajime Tsujimoto, Hirotaka Tomiyasu
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Histiocytic sarcoma (HS) is an incurable aggressive tumor, and no consensus has been made on the treatment due to its rare occurrence. Since dogs spontaneously develop the disease and several cell lines are available, they have been advocate
Externí odkaz:
https://doaj.org/article/af03d2782b0446e39e0c30681c9b4fd7
Publikováno v:
Veterinary Sciences, Vol 10, Iss 3, p 232 (2023)
Cats urgently visit emergency hospitals due to respiratory distress, and the chief cause is cardiogenic pulmonary edema (CPE). Although cats with CPE were frequently encountered in clinics, the prognostic factors were poorly reported. The objective o
Externí odkaz:
https://doaj.org/article/2fd0adc715cf4fc2a874e0b143df96fe
Autor:
Charles E Grimshaw, Andy Jennings, Ruhi Kamran, Hikaru Ueno, Nobuhiro Nishigaki, Takuo Kosaka, Akiyoshi Tani, Hiroki Sano, Yoshinobu Kinugawa, Emiko Koumura, Lihong Shi, Koji Takeuchi
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0157509 (2016)
Trelagliptin (SYR-472), a novel dipeptidyl peptidase-4 inhibitor, shows sustained efficacy by once-weekly dosing in type 2 diabetes patients. In this study, we characterized in vitro properties of trelagliptin, which exhibited approximately 4- and 12
Externí odkaz:
https://doaj.org/article/c2f5e8f538fd4b978e232dde76104e2e
Autor:
Akiyoshi TANI, Kota NAKASE, Hirotaka TOMIYASU, Sakurako NEO, Aki OHMI, Yuko GOTO-KOSHINO, Koichi OHNO, Hajime TSUJIMOTO
Publikováno v:
Journal of Veterinary Medical Science; 2024, Vol. 86 Issue 7, p737-743, 7p
Autor:
Tatsuro Hitsumoto, Osamu Tsukamoto, Ken Matsuoka, Junjun Li, Li Liu, Yuki Kuramoto, Shuichiro Higo, Shou Ogawa, Noboru Fujino, Shohei Yoshida, Hidetaka Kioka, Hisakazu Kato, Hideyuki Hakui, Yuki Saito, Chisato Okamoto, Hijiri Inoue, Jo Hyejin, Kyoko Ueda, Takatsugu Segawa, Shunsuke Nishimura, Yoshihiro Asano, Hiroshi Asanuma, Akiyoshi Tani, Riyo Imamura, Shinsuke Komagawa, Toshio Kanai, Masayuki Takamura, Yasushi Sakata, Masafumi Kitakaze, Jun-ichi Haruta, Seiji Takashima
Publikováno v:
Circulation.
Background: Cardiac-specific myosin light chain kinase (cMLCK), encoded by MYLK3 , regulates cardiac contractility through phosphorylation of ventricular myosin regulatory light chain. However, the pathophysiological and therapeutic implications of c
Autor:
Taiichiro Shirai, Akiko Nakai, Emiko Ando, Jun Fujimoto, Sarah Leach, Takao Arimori, Daisuke Higo, Floris J. van Eerden, Janyerkye Tulyeu, Yu-Chen Liu, Daisuke Okuzaki, Masanori A. Murayama, Haruhiko Miyata, Kazuto Nunomura, Bangzhong Lin, Akiyoshi Tani, Atsushi Kumanogoh, Masahito Ikawa, James B. Wing, Daron M. Standley, Junichi Takagi, Kazuhiro Suzuki
Publikováno v:
Science Immunology. 8
Celastrol, a bioactive molecule extracted from the Tripterygium wilfordii plant, has been shown to exhibit anti-inflammatory properties. However, its mechanism of action has not been fully elucidated. Here, we show that celastrol suppresses humoral i
Autor:
Miyuki Hirabayashi, James K. Chambers, Akiyoshi Tani, Hirotaka Tomiyasu, Tomoki Motegi, Kenji Rimpo, Hiroyuki Nakayama, Kazuyuki Uchida
Publikováno v:
Veterinary and Comparative Oncology. 20:587-601
Canine histiocytic proliferative disorders include aggressive and fatal diseases, such as histiocytic sarcoma (HS) and histiocytosis (SyH). The molecular mechanisms underlying cell proliferation need to be elucidated for the development of effective
Autor:
Akiyoshi TANI, Hirotaka TOMIYASU, Hajime ASADA, Chen-Si LIN, Yuko GOTO-KOSHINO, Koichi OHNO, Hajime TSUJIMOTO
Publikováno v:
The Journal of veterinary medical science. 84(5)
Interactions between tumor and immune cells within the tumor microenvironment play an important role in tumor progression, and small extracellular vesicles (EVs) derived from these tumor cells have been shown to exert immunomodulatory effects on vari